Standard name Systematic name Name description Description
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication
Visualize the interactome of CAF4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.982 0.793 0.639
Vac/Vac Memb 0.112 0.207 0.111
Cell Periphery NaN 0.052 NaN
ER NaN 0.074 0.167
Golgi NaN 0.156 NaN
Cort. Patches NaN NaN 0.056
Cytoplasm NaN NaN 0.083
Nucleus NaN NaN 0.056

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 589

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CAF4 2 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance physical 11 5 5 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-localization, Co-crystal Structure, Two-hybrid, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Affinity Capture-MS
MDV1 YJL112W Peripheral protein of cytosolic face of mitochondrial outer membrane genetic 5 1 4 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization physical 4 3 3 Two-hybrid, Co-localization, Affinity Capture-Western, Affinity Capture-Western
MDV1 YJL112W Peripheral protein of cytosolic face of mitochondrial outer membrane physical 4 3 2 Two-hybrid, Two-hybrid, Affinity Capture-Western, Co-localization
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance genetic 3 1 2 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
GRE2 YOL151W 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SPR2 YOR214C Putative spore wall protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 2 2 2 Two-hybrid, Affinity Capture-RNA
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
TAD2 YJL035C Subunit of tRNA-specific adenosine-34 deaminase genetic 2 1 2 Negative Genetic, Negative Genetic
FRT2 YAL028W Tail-anchored ER membrane protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YDL211C YDL211C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YDR248C YDR248C Putative gluconokinase genetic 2 1 2 Negative Genetic, Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
YGK1 YGL101W 5'-deoxynucleotidase genetic 2 1 2 Negative Genetic, Negative Genetic
TPC1 YGR096W Mitochondrial membrane transporter genetic 2 1 2 Negative Genetic, Negative Genetic
HXT5 YHR096C Hexose transporter with moderate affinity for glucose genetic 2 1 2 Negative Genetic, Negative Genetic
HPM1 YIL110W AdoMet-dependent methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
PEX1 YKL197C AAA-peroxin genetic 2 1 2 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Negative Genetic, Negative Genetic
SWM2 YNR004W Protein with a role in snRNA and snoRNA cap trimethylation genetic 2 1 2 Negative Genetic, Negative Genetic
GIP3 YPL137C Cytoplasmic protein that regulates protein phosphatase 1 Glc7p genetic 2 1 2 Negative Genetic, Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 2 2 1 Affinity Capture-Western, Two-hybrid
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PRX1 YBL064C Mitochondrial peroxiredoxin with thioredoxin peroxidase activity genetic 2 1 1 Negative Genetic, Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 1 1 Negative Genetic, Negative Genetic
MTO1 YGL236C Mitochondrial protein genetic 2 1 1 Negative Genetic, Negative Genetic
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
HXT8 YJL214W Protein of unknown function with similarity to hexose transporters genetic 2 1 1 Negative Genetic, Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
ENV9 YOR246C Conserved oxidoreductase involved in lipid droplet morphology genetic 2 1 1 Negative Genetic, Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 2 1 1 Negative Genetic, Negative Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 2 1 1 Positive Genetic, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Positive Genetic
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
ATP3 YBR039W Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
ARE1 YCR048W Acyl-CoA:sterol acyltransferase physical 1 1 1 Two-hybrid
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) physical 1 1 1 Affinity Capture-MS
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
YBL029W YBL029W Non-essential protein of unknown function physical 1 1 1 Affinity Capture-MS
ENT2 YLR206W Epsin-like protein required for endocytosis and actin patch assembly physical 1 1 1 Affinity Capture-MS
OSH7 YHR001W Oxysterol-binding phosphatidylserine transferase physical 1 1 1 Affinity Capture-MS
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex physical 1 1 1 Affinity Capture-MS
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 1 1 1 Two-hybrid
SSN3 YPL042C Component of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 1 1 1 Two-hybrid
MTF1 YMR228W Mitochondrial RNA polymerase specificity factor physical 1 1 1 Affinity Capture-MS
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 1 1 1 Two-hybrid
SPR3 YGR059W Sporulation-specific homolog of the CDC3/10/11/12 family of genes physical 1 1 1 Two-hybrid
ETP1 YHL010C Protein of unknown function required for growth on ethanol physical 1 1 1 Two-hybrid
SGM1 YJR134C Protein of unknown function physical 1 1 1 Two-hybrid
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p physical 1 1 1 Two-hybrid
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-RNA
STL1 YDR536W Glycerol proton symporter of the plasma membrane physical 1 1 1 Affinity Capture-RNA
STL1 YDR536W Glycerol proton symporter of the plasma membrane genetic 1 1 1 Negative Genetic
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 1 1 1 Synthetic Rescue
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Phenotypic Enhancement
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Positive Genetic
YPK3 YBR028C AGC kinase genetic 1 1 1 Negative Genetic
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SYF2 YGR129W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
NTA1 YJR062C Amidase genetic 1 1 1 Negative Genetic
YPF1 YKL100C Intramembrane aspartyl protease of the perinuclear ER membrane genetic 1 1 1 Negative Genetic
PEX13 YLR191W Peroxisomal importomer complex component genetic 1 1 1 Negative Genetic
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
PIM1 YBL022C ATP-dependent Lon protease genetic 1 1 1 Negative Genetic
CAX4 YGR036C Dolichyl pyrophosphate (Dol-P-P) phosphatase genetic 1 1 1 Positive Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Dosage Growth Defect
PRK1 YIL095W Ser/Thr protein kinase genetic 1 1 1 Dosage Growth Defect
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Growth Defect
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
NOB1 YOR056C Protein involved in proteasomal and 40S ribosomal subunit biogenesis genetic 1 1 1 Positive Genetic
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
TAX4 YJL083W EH domain-containing protein genetic 1 1 1 Positive Genetic
EMA19 YLR050C Integral ER membrane protein involved in protein sorting genetic 1 1 1 Positive Genetic
YMR084W YMR084W Putative protein of unknown function genetic 1 1 1 Positive Genetic
FCY1 YPR062W Cytosine deaminase genetic 1 1 1 Positive Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
GPI1 YGR216C Membrane protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
TRP4 YDR354W Anthranilate phosphoribosyl transferase genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Negative Genetic
MRPL9 YGR220C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TCD1 YHR003C tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
YPS7 YDR349C Putative GPI-anchored aspartic protease genetic 1 1 1 Negative Genetic
CIN10 YDR387C Putative transporter genetic 1 1 1 Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
YGL036W YGL036W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
INM1 YHR046C Inositol monophosphatase genetic 1 1 1 Negative Genetic
PXP2 YJR111C Peroxisomal matrix protein with naturally active promoter genetic 1 1 1 Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
YMR030W-A YMR030W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
LAP2 YNL045W Leucyl aminopeptidase yscIV with epoxide hydrolase activity genetic 1 1 1 Negative Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
MEP2 YNL142W Ammonium permease involved in regulation of pseudohyphal growth genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Negative Genetic
AAD10 YJR155W Putative aryl-alcohol dehydrogenase genetic 1 1 1 Negative Genetic