Standard name Systematic name Name description Description
DFM1 YDR411C Endoplasmic reticulum (ER) localized protein Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
Visualize the interactome of DFM1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
ER 0.213 0.235 0.210
Mito 0.106 NaN NaN
Nuc Periphery 0.406 0.335 0.339
Vac/Vac Memb 0.522 0.577 0.468
Cytoplasm NaN NaN 0.075
Nucleus NaN NaN 0.054

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DFM1 1 0 0 2 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
HRD3 YLR207W ER membrane protein that plays a central role in ERAD physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
HSP30 YCR021C Negative regulator of the H(+)-ATPase Pma1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBX7 YBR273C UBX (ubiquitin regulatory X) domain-containing protein physical 2 2 2 Two-hybrid, Affinity Capture-Western
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase physical 2 2 2 Two-hybrid, Affinity Capture-MS
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 2 1 1 Negative Genetic, Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 2 1 1 Positive Genetic, Positive Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 2 1 1 Positive Genetic, Positive Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
PMT4 YJR143C Protein O-mannosyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 2 1 1 Positive Genetic, Positive Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 2 1 1 Positive Genetic, Positive Genetic
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 2 1 1 Negative Genetic, Negative Genetic
KGD2 YDR148C Dihydrolipoyl transsuccinylase genetic 2 1 1 Negative Genetic, Negative Genetic
VTC1 YER072W Regulatory subunit of the vacuolar transporter chaperone (VTC) complex genetic 2 1 1 Negative Genetic, Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 2 1 1 Negative Genetic, Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 2 1 1 Negative Genetic, Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Dosage Growth Defect
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
ATG3 YNR007C E2-like enzyme genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway physical 1 1 1 Biochemical Activity
ATG34 YOL083W Receptor protein involved in selective autophagy during starvation genetic 1 1 1 Positive Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth genetic 1 1 1 Negative Genetic
COQ10 YOL008W Coenzyme Q (ubiquinone) binding protein genetic 1 1 1 Negative Genetic
CBS1 YDL069C Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Negative Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis physical 1 1 1 Biochemical Activity
UIP3 YAR027W Putative integral membrane protein of unknown function physical 1 1 1 Two-hybrid
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Two-hybrid
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis physical 1 1 1 Two-hybrid
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
DFM1 YDR411C Endoplasmic reticulum (ER) localized protein physical 1 1 1 Affinity Capture-Western
HRD3 YLR207W ER membrane protein that plays a central role in ERAD genetic 1 1 1 Phenotypic Suppression
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-MS
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 1 1 1 Affinity Capture-MS
YOS9 YDR057W ER quality-control lectin physical 1 1 1 Affinity Capture-MS
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p physical 1 1 1 Affinity Capture-Western
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-Western
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane physical 1 1 1 Affinity Capture-MS
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
YPF1 YKL100C Intramembrane aspartyl protease of the perinuclear ER membrane physical 1 1 1 Affinity Capture-Western
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Phenotypic Suppression
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Dosage Growth Defect
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 1 1 1 Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
KAP123 YER110C Karyopherin beta genetic 1 1 1 Positive Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
RLI1 YDR091C Essential Fe-S protein genetic 1 1 1 Negative Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
MVP1 YMR004W Protein required for sorting proteins to the vacuole genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
YOR186W YOR186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 1 1 1 Phenotypic Enhancement
ADY2 YCR010C Acetate transporter required for normal sporulation genetic 1 1 1 Negative Genetic