Standard name Systematic name Name description Description
LAG2 YOL025W Protein that negatively regulates the SCF E3-ubiquitin ligase Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1
Visualize the interactome of LAG2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data 195

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
LAG2 2 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC53 YDL132W Cullin physical 9 4 3 Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-purification
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 4 3 3 Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 genetic 4 3 2 Synthetic Growth Defect, Synthetic Rescue, Dosage Growth Defect, Synthetic Growth Defect
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes physical 3 3 2 Affinity Capture-Western, Reconstituted Complex, Co-purification
DCN1 YLR128W Scaffold-type E3 ligase genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
SKP1 YDR328C Evolutionarily conserved kinetochore protein genetic 2 2 2 Dosage Growth Defect, Synthetic Rescue
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway genetic 2 1 2 Negative Genetic, Negative Genetic
CYB5 YNL111C Cytochrome b5 genetic 2 1 2 Negative Genetic, Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
AIM17 YHL021C Protein of unknown function genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin genetic 1 1 1 Synthetic Growth Defect
DAS1 YJL149W Putative SCF ubiquitin ligase F-box protein physical 1 1 1 Two-hybrid
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
FMP40 YPL222W Mitochondrial AMPylator in the pseudokinase selenoprotein-O family genetic 1 1 1 Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
DCN1 YLR128W Scaffold-type E3 ligase physical 1 1 1 Reconstituted Complex
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
YDR131C YDR131C F-box protein subunit of SCF ubiquitin ligase complex physical 1 1 1 Two-hybrid
PFU1 YDR306C F-box protein that regulates pheromone-dependent morphogenesis physical 1 1 1 Two-hybrid
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex physical 1 1 1 Reconstituted Complex
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-RNA
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
MSS11 YMR164C Transcription factor genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Positive Genetic
UTP4 YDR324C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
RRN9 YMR270C Protein involved in promoting high level transcription of rDNA genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
MDH3 YDL078C Peroxisomal malate dehydrogenase genetic 1 1 1 Negative Genetic
YFR006W YFR006W Putative X-Pro aminopeptidase genetic 1 1 1 Negative Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Negative Genetic
YLR415C YLR415C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Negative Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
LAP2 YNL045W Leucyl aminopeptidase yscIV with epoxide hydrolase activity genetic 1 1 1 Negative Genetic
RCR1 YBR005W Plasma membrane (PM) ubiquitin ligase-substrate adaptor genetic 1 1 1 Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Negative Genetic
TPH3 YJL016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 1 1 1 Negative Genetic
YOR296W YOR296W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOR381W-A YOR381W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic