Standard name Systematic name Name description Description
MLC1 YGL106W Essential light chain for Myo1p Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
Visualize the interactome of MLC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MLC1 0 0 3 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 15 5 12 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Co-crystal Structure, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-Western
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation physical 8 5 6 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, PCA, PCA, Reconstituted Complex, Affinity Capture-MS
MYO1 YHR023W Type II myosin heavy chain physical 7 2 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 3 2 3 Synthetic Rescue, Synthetic Rescue, Dosage Rescue
CMD1 YBR109C Calmodulin physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid
MYO4 YAL029C Type V myosin motor involved in actin-based transport of cargos physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MYO1 YHR023W Type II myosin heavy chain genetic 2 2 2 Synthetic Lethality, Dosage Rescue
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation genetic 2 1 2 Dosage Rescue, Dosage Rescue
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HCA4 YJL033W DEAD box RNA helicase physical 1 1 1 Affinity Capture-MS
CDC33 YOL139C Translation initiation factor eIF4E physical 1 1 1 Affinity Capture-MS
HGH1 YGR187C Chaperone protein for translation factor eEF2 physical 1 1 1 Affinity Capture-MS
BNI1 YNL271C Formin physical 1 1 1 PCA
FAP1 YNL023C Protein that binds to Fpr1p physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 1 1 1 Affinity Capture-MS
MYO4 YAL029C Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Dosage Rescue
SEC4 YFL005W Rab family GTPase physical 1 1 1 Affinity Capture-Western
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination physical 1 1 1 Affinity Capture-Western
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination genetic 1 1 1 Dosage Rescue
SAW1 YAL027W 5'- and 3'-flap DNA binding protein physical 1 1 1 Affinity Capture-MS
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
NTH2 YBR001C Putative neutral trehalase, required for thermotolerance physical 1 1 1 Affinity Capture-MS
RKM3 YBR030W Ribosomal lysine methyltransferase physical 1 1 1 Affinity Capture-MS
UBP14 YBR058C Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
PYC2 YBR218C Pyruvate carboxylase isoform physical 1 1 1 Affinity Capture-MS
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response physical 1 1 1 Affinity Capture-MS
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 1 1 1 Affinity Capture-MS
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
SSH4 YKL124W Specificity factor required for Rsp5p-dependent ubiquitination physical 1 1 1 Affinity Capture-MS
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation physical 1 1 1 Affinity Capture-MS
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA physical 1 1 1 Affinity Capture-MS
RAD33 YML011C Protein involved in nucleotide excision repair physical 1 1 1 Affinity Capture-MS
SRC1 YML034W Inner nuclear membrane protein physical 1 1 1 Affinity Capture-MS
TVP18 YMR071C Integral membrane protein physical 1 1 1 Affinity Capture-MS
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Affinity Capture-MS
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
SDD3 YOL098C Putative metalloprotease physical 1 1 1 Affinity Capture-MS
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain physical 1 1 1 Affinity Capture-MS
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) physical 1 1 1 Affinity Capture-MS
RAD17 YOR368W Checkpoint protein physical 1 1 1 Affinity Capture-MS
MLC2 YPR188C Regulatory light chain for the type II myosin Myo1p physical 1 1 1 Affinity Capture-MS
MLC1 YGL106W Essential light chain for Myo1p physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PIK1 YNL267W Phosphatidylinositol 4-kinase physical 1 1 1 Two-hybrid
MPS1 YDL028C Dual-specificity kinase physical 1 1 1 Affinity Capture-MS
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 PCA
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 1 1 1 PCA
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
PEA2 YER149C Coiled-coil 12S polarisome subunit physical 1 1 1 PCA
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
MRS6 YOR370C Rab escort protein genetic 1 1 1 Dosage Rescue
YPT32 YGL210W Rab family GTPase involved in the exocytic pathway genetic 1 1 1 Synthetic Growth Defect
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Dosage Growth Defect
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton physical 1 1 1 Affinity Capture-MS
CRN1 YLR429W Coronin physical 1 1 1 Affinity Capture-MS
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
ACO1 YLR304C Aconitase physical 1 1 1 Affinity Capture-MS
LSP1 YPL004C Eisosome core component physical 1 1 1 Affinity Capture-MS
BUD32 YGR262C Protein kinase genetic 1 1 1 Dosage Growth Defect
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein physical 1 1 1 Affinity Capture-MS
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization physical 1 1 1 Reconstituted Complex
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase physical 1 1 1 Affinity Capture-MS
BUD6 YLR319C Actin- and formin-interacting protein physical 1 1 1 Affinity Capture-MS
ACF2 YLR144C Intracellular beta-1,3-endoglucanase physical 1 1 1 Affinity Capture-MS
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase physical 1 1 1 Affinity Capture-MS
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase physical 1 1 1 Affinity Capture-MS
DDR48 YMR173W DNA damage-responsive protein physical 1 1 1 Affinity Capture-MS
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain physical 1 1 1 Affinity Capture-MS
ATG33 YLR356W Mitochondrial mitophagy-specific protein physical 1 1 1 Affinity Capture-MS
ISM1 YPL040C Mitochondrial isoleucyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS