| DMC1 |
YER179W |
Meiosis-specific recombinase required for double-strand break repair |
genetic |
10 |
4 |
7 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression |
| REC104 |
YHR157W |
Protein involved in early stages of meiotic recombination |
physical |
6 |
2 |
4 |
Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid |
| NDT80 |
YHR124W |
Meiosis-specific transcription factor |
genetic |
5 |
2 |
5 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression |
| SKI8 |
YGL213C |
Ski complex component and WD-repeat protein |
physical |
5 |
2 |
4 |
Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western |
| REC102 |
YLR329W |
Protein involved in early stages of meiotic recombination |
physical |
5 |
2 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
| SPO13 |
YHR014W |
Meiotic regulator |
genetic |
4 |
1 |
4 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| PCH2 |
YBR186W |
Hexameric ring ATPase that remodels chromosome axis protein Hop1p |
genetic |
4 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression |
| MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression |
| MND2 |
YIR025W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement |
| SAE2 |
YGL175C |
Endonuclease required for telomere elongation |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression |
| REC102 |
YLR329W |
Protein involved in early stages of meiotic recombination |
genetic |
3 |
3 |
2 |
Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
| CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
| SKI8 |
YGL213C |
Ski complex component and WD-repeat protein |
genetic |
2 |
2 |
2 |
Dosage Rescue, Negative Genetic |
| RAD17 |
YOR368W |
Checkpoint protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
| REC8 |
YPR007C |
Meiosis-specific component of the sister chromatid cohesion complex |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
| NDJ1 |
YOL104C |
Protein that regulates meiotic SPB cohesion and telomere clustering |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Phenotypic Enhancement |
| SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Co-localization |
| ZIP1 |
YDR285W |
Transverse filament protein of the synaptonemal complex |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
| MAM1 |
YER106W |
Monopolin |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Enhancement |
| SAE3 |
YHR079C-A |
Meiosis-specific protein involved in meiotic recombination |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ADH3 |
YMR083W |
Mitochondrial alcohol dehydrogenase isozyme III |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MHP1 |
YJL042W |
Microtubule-associated protein involved in microtubule organization |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| UTR2 |
YEL040W |
Chitin transglycosylase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SUT1 |
YGL162W |
Zn(II)2Cys6 family transcription factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YSR3 |
YKR053C |
Dihydrosphingosine 1-phosphate phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YEN1 |
YER041W |
Holliday junction resolvase |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| GMC2 |
YLR445W |
Protein involved in meiotic crossing over |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| FPR3 |
YML074C |
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Phenotypic Enhancement |
| MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Dosage Rescue |
| NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Phenotypic Enhancement |
| CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| RAD24 |
YER173W |
Checkpoint protein |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PAB1 |
YER165W |
Poly(A) binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IML1 |
YJR138W |
GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA49 |
YNL248C |
RNA polymerase I subunit A49 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HHF2 |
YNL030W |
Histone H4 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRR1 |
YIL026C |
Subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MDM10 |
YAL010C |
Subunit of both the ERMES and the SAM complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MLH1 |
YMR167W |
Protein required for mismatch repair in mitosis and meiosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IMG1 |
YCR046C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ITC1 |
YGL133W |
Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AHA1 |
YDR214W |
Co-chaperone that binds Hsp82p and activates its ATPase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCT8 |
YJL008C |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSH4 |
YFL003C |
Protein involved in meiotic recombination |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSM7 |
YJR113C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RHO2 |
YNL090W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMA1 |
YGL008C |
Plasma membrane P2-type H+-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APM3 |
YBR288C |
Mu3-like subunit of the clathrin associated protein complex (AP-3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDS1 |
YDR113C |
Securin |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ARE2 |
YNR019W |
Acyl-CoA:sterol acyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| KKQ8 |
YKL168C |
Putative serine/threonine protein kinase with unknown cellular role |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ECM11 |
YDR446W |
Meiosis-specific protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ATP20 |
YPR020W |
Subunit g of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSE4 |
YKL049C |
Centromeric histone H3-like protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CST9 |
YLR394W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INP53 |
YOR109W |
Polyphosphatidylinositol phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| REC104 |
YHR157W |
Protein involved in early stages of meiotic recombination |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| REC114 |
YMR133W |
Protein involved in early stages of meiotic recombination |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| REC8 |
YPR007C |
Meiosis-specific component of the sister chromatid cohesion complex |
physical |
1 |
1 |
1 |
Co-localization |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| REV1 |
YOR346W |
Deoxycytidyl transferase |
physical |
1 |
1 |
1 |
Two-hybrid |
| PDC2 |
YDR081C |
Transcription factor for thiamine-regulated genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BYE1 |
YKL005C |
Negative regulator of transcription elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RDH54 |
YBR073W |
DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SPE2 |
YOL052C |
S-adenosylmethionine decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL43A |
YPR043W |
Ribosomal 60S subunit protein L43A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT106 |
YNL206C |
Histone chaperone |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HED1 |
YDR014W-A |
Meiosis-specific protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SSD1 |
YDR293C |
Translational repressor |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SPO12 |
YHR152W |
Nucleolar protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPO74 |
YGL170C |
Component of the meiotic outer plaque of the spindle pole body |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TMH11 |
YJR085C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUS1 |
YLR425W |
Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMR090W |
YMR090W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YVC1 |
YOR087W |
Vacuolar cation channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSM4 |
YPL200W |
Protein required for accurate chromosome segregation during meiosis |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| GMC1 |
YDR506C |
Protein involved in meiotic progression |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCF3 |
YBR255C-A |
Mitochondrial inner membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MND1 |
YGL183C |
Protein required for recombination and meiotic nuclear division |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PAU23 |
YLR037C |
Cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Negative Genetic |
