Standard name Systematic name Name description Description
TWF1 YGR080W Twinfilin Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1
Visualize the interactome of TWF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.180 0.184 0.214
Budsite 0.090 NaN NaN
Cort. Patches 0.361 0.447 0.619
ER 0.074 0.087 NaN
Mito 0.836 0.670 0.452
Peroxisome 0.139 0.146 0.226
Cytoplasm NaN 0.068 NaN
Golgi NaN 0.146 0.310

GFP localization & abundance

GFP localization GFP abundance
actin 1470

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TWF1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 6 3 4 Reconstituted Complex, Co-localization, Reconstituted Complex, Co-fractionation, Reconstituted Complex, Reconstituted Complex
SRV2 YNL138W CAP (cyclase-associated protein) physical 3 3 3 PCA, Affinity Capture-MS, Reconstituted Complex
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Lethality
PFY1 YOR122C Profilin genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
CRN1 YLR429W Coronin genetic 2 2 1 Synthetic Lethality, Phenotypic Enhancement
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Negative Genetic, Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ERB1 YMR049C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
NOP15 YNL110C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Affinity Capture-MS
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) physical 1 1 1 Reconstituted Complex
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
BNI1 YNL271C Formin physical 1 1 1 Reconstituted Complex
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RRI1 YDL216C Catalytic subunit of the COP9 signalosome (CSN) complex genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
AIP1 YMR092C Actin cortical patch component genetic 1 1 1 Phenotypic Enhancement
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 1 1 1 Negative Genetic
LUG1 YLR352W Protein of unknown function with similarity to F-box proteins genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
AIM3 YBR108W Protein that inhibits barbed-end actin filament elongation genetic 1 1 1 Negative Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase physical 1 1 1 Affinity Capture-MS
AIM7 YDR063W Protein that interacts with Arp2/3 complex genetic 1 1 1 Phenotypic Enhancement
ART5 YGR068C Protein proposed to regulate endocytosis of plasma membrane proteins physical 1 1 1 Affinity Capture-MS
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
MCM1 YMR043W Transcription factor genetic 1 1 1 Positive Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Positive Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Positive Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Positive Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
RCN1 YKL159C Protein involved in calcineurin regulation during calcium signaling genetic 1 1 1 Negative Genetic
THR1 YHR025W Homoserine kinase genetic 1 1 1 Negative Genetic
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Positive Genetic
TWF1 YGR080W Twinfilin physical 1 1 1 PCA
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Positive Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Negative Genetic
YIR016W YIR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YLL053C YLL053C Putative protein genetic 1 1 1 Negative Genetic
YMR321C YMR321C Putative protein of unknown function genetic 1 1 1 Negative Genetic
GPI18 YBR004C Functional ortholog of human PIG-V genetic 1 1 1 Negative Genetic
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic