Standard name Systematic name Name description Description
CNS1 YBR155W TPR-containing co-chaperone TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant
Visualize the interactome of CNS1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.98 0.994 0.957
Cell Periphery NaN NaN 0.063

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 672

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CNS1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 11 5 8 Dosage Rescue, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect, Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement
HSP82 YPL240C Hsp90 chaperone physical 11 4 7 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
HGH1 YGR187C Chaperone protein for translation factor eEF2 physical 5 3 4 Affinity Capture-MS, PCA, PCA, Affinity Capture-MS, Reconstituted Complex
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 4 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation
HSP82 YPL240C Hsp90 chaperone genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 3 2 1 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 2 2 Reconstituted Complex, Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 2 2 Dosage Rescue, Synthetic Growth Defect
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 2 1 2 Dosage Growth Defect, Dosage Growth Defect
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 physical 2 2 1 Affinity Capture-MS, Reconstituted Complex
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 Affinity Capture-MS
ILV5 YLR355C Acetohydroxyacid reductoisomerase and mtDNA binding protein physical 1 1 1 Affinity Capture-MS
ECM10 YEL030W Heat shock protein of the Hsp70 family physical 1 1 1 Affinity Capture-MS
STP1 YDR463W Transcription factor physical 1 1 1 Two-hybrid
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-Western
GEA1 YJR031C Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
HSL1 YKL101W Nim1p-related protein kinase physical 1 1 1 Biochemical Activity
IPL1 YPL209C Aurora kinase of chromosomal passenger complex physical 1 1 1 Biochemical Activity
SKY1 YMR216C SR protein kinase (SRPK) physical 1 1 1 Biochemical Activity
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Biochemical Activity
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
FRK1 YPL141C Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation physical 1 1 1 Two-hybrid
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones physical 1 1 1 Two-hybrid
SER3 YER081W 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase physical 1 1 1 Two-hybrid
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
RPS1A YLR441C Ribosomal protein of the small (40S) subunit genetic 1 1 1 Dosage Growth Defect
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 1 1 1 Affinity Capture-MS
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor physical 1 1 1 Two-hybrid
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Biochemical Activity
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA