Standard name Systematic name Name description Description
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication
Visualize the interactome of MTH1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1 256

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MTH1 0 0 0 1 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
STD1 YOR047C Protein involved in control of glucose-regulated gene expression genetic 7 4 7 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Dosage Lethality, Phenotypic Enhancement, Phenotypic Enhancement
RGT1 YKL038W Glucose-responsive transcription factor physical 5 3 3 Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western
SNF3 YDL194W Plasma membrane low glucose sensor, regulates glucose transport genetic 3 2 3 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
STP2 YHR006W Transcription factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 2 2 2 Dosage Rescue, Synthetic Growth Defect
LSM8 YJR022W Lsm (Like Sm) protein physical 2 1 2 Two-hybrid, Two-hybrid
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 2 1 2 Negative Genetic, Negative Genetic
RGT2 YDL138W Plasma membrane high glucose sensor that regulates glucose transport genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
SNF3 YDL194W Plasma membrane low glucose sensor, regulates glucose transport physical 2 1 2 Two-hybrid, Two-hybrid
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
YGR130C YGR130C Component of the eisosome with unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RCN2 YOR220W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
HXT3 YDR345C Low affinity glucose transporter of the major facilitator superfamily genetic 2 1 2 Dosage Rescue, Dosage Rescue
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily genetic 2 1 2 Dosage Rescue, Dosage Rescue
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 2 1 2 Negative Genetic, Negative Genetic
MSS2 YDL107W Peripherally bound inner membrane protein of the mitochondrial matrix genetic 2 1 2 Negative Genetic, Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger physical 2 2 1 Two-hybrid, Reconstituted Complex
PSY2 YNL201C Subunit of protein phosphatase PP4 complex physical 2 2 1 Two-hybrid, Affinity Capture-Western
YPL264C YPL264C Endoplasmic reticulum protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family regulation 1 1 1 RNA-sequencing evidence
SIR3 YLR442C Silencing protein regulation 1 1 1 RNA-sequencing evidence
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains regulation 1 1 1 RNA-sequencing evidence
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUC2 YIL162W Invertase regulation 1 1 1 enzymatic activity assay evidence
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BEM1 YBR200W Protein containing SH3-domains physical 1 1 1 Two-hybrid
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 Two-hybrid
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Two-hybrid
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization physical 1 1 1 Two-hybrid
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex physical 1 1 1 Two-hybrid
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 1 1 1 Two-hybrid
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 Two-hybrid
BBC1 YJL020C Protein possibly involved in assembly of actin patches physical 1 1 1 Two-hybrid
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Dosage Lethality
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway physical 1 1 1 Two-hybrid
FPK1 YNR047W Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
COQ5 YML110C 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
RGT1 YKL038W Glucose-responsive transcription factor genetic 1 1 1 Phenotypic Suppression
RGT2 YDL138W Plasma membrane high glucose sensor that regulates glucose transport physical 1 1 1 Two-hybrid
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase physical 1 1 1 Two-hybrid
MYO3 YKL129C One of two type I myosins physical 1 1 1 Two-hybrid
MYO5 YMR109W One of two type I myosin motors physical 1 1 1 Two-hybrid
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway physical 1 1 1 Two-hybrid
PEX13 YLR191W Peroxisomal importomer complex component physical 1 1 1 Two-hybrid
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
UFO1 YML088W F-box receptor protein physical 1 1 1 Affinity Capture-MS
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Phenotypic Suppression
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity physical 1 1 1 Two-hybrid
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Dosage Rescue
PYC1 YGL062W Pyruvate carboxylase isoform genetic 1 1 1 Dosage Rescue
SDD1 YEL057C Protein of unknown function genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 1 1 1 Synthetic Rescue
PDC5 YLR134W Minor isoform of pyruvate decarboxylase genetic 1 1 1 Synthetic Rescue
PDC6 YGR087C Minor isoform of pyruvate decarboxylase genetic 1 1 1 Synthetic Rescue
TUP1 YCR084C General repressor of transcription in complex with Cyc8p genetic 1 1 1 Phenotypic Suppression
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Phenotypic Suppression
PLC1 YPL268W Phospholipase C genetic 1 1 1 Phenotypic Suppression
SET4 YJL105W Chromatin-associated protein involved in control of stress response genetic 1 1 1 Positive Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Positive Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Negative Genetic
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
TOK1 YJL093C Outward-rectifier potassium channel of the plasma membrane genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
RSM26 YJR101W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
RSM7 YJR113C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
UPS2 YLR168C Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
YML053C YML053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
CAT8 YMR280C Zinc cluster transcriptional activator genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Phenotypic Enhancement
GAT1 YFL021W Transcriptional activator of nitrogen catabolite repression genes genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
KIN82 YCR091W Putative serine/threonine protein kinase genetic 1 1 1 Negative Genetic
MSK1 YNL073W Mitochondrial lysine-tRNA synthetase physical 1 1 1 Two-hybrid
HXT4 YHR092C High-affinity glucose transporter genetic 1 1 1 Dosage Rescue
COS1 YNL336W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Negative Genetic
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Negative Genetic
CWC27 YPL064C Component of a complex containing Cef1p genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic