Standard name Systematic name Name description Description
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers
Visualize the interactome of NOT5
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.958 0.950 0.918
ER NaN 0.068 NaN
Cell Periphery NaN NaN 0.104

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 5110

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
NOT5 6 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 13 6 11 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-purification, PCA, Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Co-purification
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex physical 9 4 9 Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex physical 9 3 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, PCA, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 6 2 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 5 4 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-RNA
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 4 2 3 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 3 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 3 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
RRP6 YOR001W Nuclear exosome exonuclease component genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 3 2 2 Dosage Rescue, Synthetic Lethality, Synthetic Lethality
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 3 3 1 Dosage Lethality, Synthetic Lethality, Synthetic Rescue
ADA2 YDR448W Transcription coactivator physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-RNA
SKI6 YGR195W Exosome non-catalytic core component physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Co-fractionation
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 2 2 2 Synthetic Lethality, Dosage Rescue
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Affinity Capture-Western
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex physical 2 2 2 Two-hybrid, Affinity Capture-Western
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 2 2 2 Dosage Rescue, Synthetic Lethality
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 2 2 2 Protein-peptide, Affinity Capture-Western
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 2 2 1 Synthetic Growth Defect, Dosage Rescue
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) physical 2 2 1 Two-hybrid, Affinity Capture-Western
TAF13 YML098W TFIID subunit (19 kDa) physical 2 2 1 Reconstituted Complex, Two-hybrid
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 2 2 1 Affinity Capture-Western, Co-fractionation
SPT15 YER148W TATA-binding protein (TBP) physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CSL4 YNL232W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-Western
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Synthetic Growth Defect
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-Western
HSL1 YKL101W Nim1p-related protein kinase physical 1 1 1 Biochemical Activity
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex physical 1 1 1 Affinity Capture-MS
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Synthetic Growth Defect
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation physical 1 1 1 Two-hybrid
NHP6B YBR089C-A High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-Western
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Lethality
BBC1 YJL020C Protein possibly involved in assembly of actin patches physical 1 1 1 Two-hybrid
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Phenotypic Enhancement
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-RNA
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 1 1 1 Synthetic Rescue
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Biochemical Activity
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
NHP6A YPR052C High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-Western
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Synthetic Growth Defect
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Two-hybrid
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Biochemical Activity
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
SKN7 YHR206W Nuclear response regulator and transcription factor physical 1 1 1 Affinity Capture-Western
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 PCA
SMY2 YBR172C GYF domain protein physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-Western
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation physical 1 1 1 Two-hybrid
STF1 YDL130W-A Protein involved in regulation of the mitochondrial F1F0-ATP synthase physical 1 1 1 Two-hybrid
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Two-hybrid
RPB4 YJL140W RNA polymerase II subunit B32 physical 1 1 1 Two-hybrid
STL1 YDR536W Glycerol proton symporter of the plasma membrane physical 1 1 1 Affinity Capture-RNA
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Synthetic Rescue
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Dosage Rescue
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Lethality
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Synthetic Growth Defect
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 1 1 1 Phenotypic Suppression
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Positive Genetic
NIP100 YPL174C Large subunit of the dynactin complex physical 1 1 1 Two-hybrid
BTT1 YDR252W Heterotrimeric nascent polypeptide-associated complex beta3 subunit physical 1 1 1 Affinity Capture-Western
KXD1 YGL079W Subunit of the BLOC-1 complex involved in endosomal maturation physical 1 1 1 Two-hybrid
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex physical 1 1 1 Two-hybrid
FRT1 YOR324C Tail-anchored ER membrane protein of unknown function physical 1 1 1 Two-hybrid