Standard name Systematic name Name description Description
PEA2 YER149C Coiled-coil 12S polarisome subunit Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion
Visualize the interactome of PEA2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 17

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.234 0.262 0.242
Budsite 0.254 0.381 0.227
Cort. Patches 0.169 0.214 0.062
Cytoplasm 0.164 0.190 0.119
Mito 0.274 0.333 0.052
Nucleolus 0.090 0.071 0.072
Nucleus 0.060 0.119 0.062
Peroxisome 0.095 0.071 0.196
SpindlePole 0.124 0.095 0.325
Cell Periphery NaN NaN 0.052
Endosome NaN NaN 0.072

GFP localization & abundance

GFP localization GFP abundance
ambiguous, cell periphery, bud 7820

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PEA2 0 0 3 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
EPO1 YMR124W Protein involved in septin-ER tethering physical 7 3 3 Two-hybrid, Two-hybrid, Two-hybrid, PCA, PCA, Reconstituted Complex, Reconstituted Complex
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 6 4 6 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SPA2 YLL021W Component of the polarisome physical 5 4 3 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, PCA
BUD6 YLR319C Actin- and formin-interacting protein physical 4 2 4 Two-hybrid, Two-hybrid, Two-hybrid, PCA
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 4 2 3 Synthetic Haploinsufficiency, Negative Genetic, Negative Genetic, Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARC40 YBR234C Subunit of the ARP2/3 complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
CHS1 YNL192W Chitin synthase I genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 2 1 2 Negative Genetic, Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 2 1 2 Negative Genetic, Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 1 2 Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 2 1 2 Two-hybrid, Two-hybrid
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 2 1 2 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 2 Negative Genetic, Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 2 1 2 Negative Genetic, Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 2 1 2 Negative Genetic, Negative Genetic
FUS1 YCL027W Membrane protein localized to the shmoo tip physical 2 1 2 Two-hybrid, Two-hybrid
CHS5 YLR330W Component of the exomer complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 2 1 2 Negative Genetic, Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 2 1 2 Negative Genetic, Negative Genetic
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 2 1 2 Negative Genetic, Negative Genetic
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 2 1 2 Negative Genetic, Negative Genetic
KIN2 YLR096W S/T protein kinase physical 2 2 1 Two-hybrid, PCA
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I physical 1 1 1 Two-hybrid
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 PCA
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 PCA
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
MLC1 YGL106W Essential light chain for Myo1p physical 1 1 1 PCA
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Positive Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Lethality
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
PAA1 YDR071C Polyamine acetyltransferase genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 1 1 1 Synthetic Lethality
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) physical 1 1 1 PCA
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Phenotypic Enhancement
KEL2 YGR238C Protein that negatively regulates mitotic exit physical 1 1 1 PCA
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Positive Genetic
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Negative Genetic
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Negative Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Rescue
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex physical 1 1 1 Two-hybrid
SMY1 YKL079W Kinesin-like myosin passenger-protein physical 1 1 1 Two-hybrid
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family physical 1 1 1 Two-hybrid
YPL216W YPL216W Putative protein of unknown function physical 1 1 1 Two-hybrid
PEA2 YER149C Coiled-coil 12S polarisome subunit physical 1 1 1 PCA
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 1 1 1 PCA
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Synthetic Lethality
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Phenotypic Suppression
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Phenotypic Suppression
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 1 1 1 Phenotypic Suppression
RTT106 YNL206C Histone chaperone genetic 1 1 1 Synthetic Lethality
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Synthetic Growth Defect
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SSY1 YDR160W Component of the SPS plasma membrane amino acid sensor system genetic 1 1 1 Negative Genetic
RKM4 YDR257C Ribosomal lysine methyltransferase genetic 1 1 1 Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
YKR018C YKR018C Protein of unknown function genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
SPO19 YPL130W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Phenotypic Suppression
PFY1 YOR122C Profilin genetic 1 1 1 Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YFH7 YFR007W Putative kinase with similarity to the PRK/URK/PANK kinase subfamily genetic 1 1 1 Negative Genetic
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Negative Genetic
PEF1 YGR058W Penta-EF-hand protein genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
YHL008C YHL008C Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
PIG2 YIL045W Putative type-1 protein phosphatase targeting subunit genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
YJR151W-A YJR151W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Negative Genetic
THI20 YOL055C Trifunctional enzyme of thiamine biosynthesis, degradation and salvage genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Positive Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector physical 1 1 1 Two-hybrid
MSB3 YNL293W Rab GTPase-activating protein physical 1 1 1 Reconstituted Complex
MSB4 YOL112W GTPase-activating protein of the Ras superfamily physical 1 1 1 Reconstituted Complex
NIP100 YPL174C Large subunit of the dynactin complex physical 1 1 1 Two-hybrid
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Two-hybrid
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Negative Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Positive Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic