Standard name Systematic name Name description Description
SBH1 YER087C-B Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication
Visualize the interactome of SBH1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
ambiguous 217

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SBH1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SEC61 YLR378C Conserved ER protein translocation channel physical 10 6 9 Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Co-fractionation
SBH2 YER019C-A Ssh1p-Sss1p-Sbh2p complex component genetic 9 4 8 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect
SEC61 YLR378C Conserved ER protein translocation channel genetic 6 3 5 Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) physical 5 3 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid
SEC63 YOR254C Essential subunit of Sec63 complex genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex physical 3 2 3 Affinity Capture-Western, PCA, PCA
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen physical 3 2 3 PCA, PCA, Two-hybrid
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen physical 3 2 2 PCA, Affinity Capture-Western, PCA
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex genetic 3 2 2 Dosage Rescue, Phenotypic Enhancement, Dosage Rescue
RTN1 YDR233C Reticulon protein physical 3 1 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SPC2 YML055W Subunit of signal peptidase complex physical 2 2 2 Affinity Capture-Western, Two-hybrid
YOP1 YPR028W Reticulon-interacting protein physical 2 2 2 Affinity Capture-Western, Two-hybrid
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 2 2 Affinity Capture-MS, Two-hybrid
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 2 2 2 Affinity Capture-MS, Two-hybrid
ATG3 YNR007C E2-like enzyme genetic 2 1 2 Negative Genetic, Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p physical 2 1 2 Reconstituted Complex, Reconstituted Complex
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Negative Genetic, Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex physical 2 1 2 PCA, PCA
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l physical 2 1 2 PCA, PCA
SEC63 YOR254C Essential subunit of Sec63 complex physical 2 1 2 Co-purification, Co-purification
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone physical 2 1 2 Reconstituted Complex, Reconstituted Complex
YIL055C YIL055C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 2 1 2 Negative Genetic, Negative Genetic
SSH4 YKL124W Specificity factor required for Rsp5p-dependent ubiquitination genetic 2 1 2 Negative Genetic, Negative Genetic
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 2 1 2 Negative Genetic, Negative Genetic
YLR460C YLR460C Member of the quinone oxidoreductase family genetic 2 1 2 Negative Genetic, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 2 Negative Genetic, Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 2 1 2 Negative Genetic, Negative Genetic
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 2 1 2 Negative Genetic, Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 2 1 2 Negative Genetic, Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 2 1 2 Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 2 2 1 Dosage Rescue, Phenotypic Enhancement
PDI1 YCL043C Protein disulfide isomerase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 1 Negative Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 2 1 1 Negative Genetic, Negative Genetic
TMN3 YER113C Protein with a role in cellular adhesion and filamentous growth genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LEU3 YLR451W Zinc-knuckle transcription factor, repressor and activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 1 1 1 Negative Genetic
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Two-hybrid
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Two-hybrid
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Two-hybrid
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase physical 1 1 1 Two-hybrid
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
BCP1 YDR361C Essential nuclear chaperone for ribosomal protein Rpl23p genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Two-hybrid
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen physical 1 1 1 PCA
PGK1 YCR012W 3-phosphoglycerate kinase physical 1 1 1 Two-hybrid
PRO2 YOR323C Gamma-glutamyl phosphate reductase physical 1 1 1 Two-hybrid
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription physical 1 1 1 Two-hybrid
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Negative Genetic
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Negative Genetic
DPS1 YLL018C Aspartyl-tRNA synthetase, primarily cytoplasmic physical 1 1 1 Two-hybrid
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
HXT7 YDR342C High-affinity glucose transporter physical 1 1 1 Two-hybrid
RTN2 YDL204W Reticulon protein physical 1 1 1 Affinity Capture-Western
HRT3 YLR097C Putative SCF-ubiquitin ligase F-box protein genetic 1 1 1 Negative Genetic
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
AIP5 YFR016C Protein that positively regulates actin assembly physical 1 1 1 Two-hybrid
RAS2 YNL098C GTP-binding protein physical 1 1 1 Two-hybrid
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Two-hybrid
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis physical 1 1 1 Two-hybrid
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 1 1 1 Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Phenotypic Enhancement
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Negative Genetic
MDR1 YGR100W Cytoplasmic GTPase-activating protein genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor physical 1 1 1 Two-hybrid
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
PNG1 YPL096W Conserved peptide N-glycanase physical 1 1 1 Two-hybrid
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex physical 1 1 1 Affinity Capture-Western
SEC4 YFL005W Rab family GTPase physical 1 1 1 Affinity Capture-Western
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex physical 1 1 1 Affinity Capture-Western
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Dosage Rescue
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) physical 1 1 1 Affinity Capture-Western
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Negative Genetic
UIP3 YAR027W Putative integral membrane protein of unknown function physical 1 1 1 Two-hybrid
SEI1 YLR404W Seipin involved in lipid droplet (LD) assembly physical 1 1 1 Two-hybrid
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
YPC1 YBR183W Alkaline ceramidase physical 1 1 1 PCA
SSH1 YBR283C Subunit of the Ssh1 translocon complex physical 1 1 1 PCA
YOL075C YOL075C Putative ABC transporter physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Two-hybrid
VPH2 YKL119C Integral membrane protein required for V-ATPase function physical 1 1 1 Two-hybrid
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 1 1 1 Two-hybrid
SCS7 YMR272C Sphingolipid alpha-hydroxylase physical 1 1 1 Two-hybrid
TSC13 YDL015C Enoyl reductase physical 1 1 1 Two-hybrid
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Two-hybrid
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) physical 1 1 1 Two-hybrid
YKR018C YKR018C Protein of unknown function physical 1 1 1 Two-hybrid
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase physical 1 1 1 Two-hybrid
UBI4 YLL039C Ubiquitin physical 1 1 1 Two-hybrid
SEC3 YER008C Subunit of the exocyst complex genetic 1 1 1 Dosage Rescue
SEC5 YDR166C Essential 107kDa subunit of the exocyst complex genetic 1 1 1 Dosage Rescue
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex genetic 1 1 1 Dosage Rescue
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Synthetic Growth Defect
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 1 1 1 Positive Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Negative Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Negative Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
OST6 YML019W Subunit of the oligosaccharyltransferase complex of the ER lumen physical 1 1 1 PCA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Two-hybrid
RGA2 YDR379W GTPase-activating protein for polarity-establishment protein Cdc42p genetic 1 1 1 Negative Genetic
GTT1 YIR038C ER associated glutathione S-transferase physical 1 1 1 Two-hybrid
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane physical 1 1 1 Affinity Capture-Western
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
KRE2 YDR483W Alpha1,2-mannosyltransferase of the Golgi physical 1 1 1 Two-hybrid
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
ALG3 YBL082C Dolichol-P-Man dependent alpha(1-3) mannosyltransferase physical 1 1 1 Two-hybrid
PDR10 YOR328W ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
CWP2 YKL096W-A Covalently linked cell wall mannoprotein physical 1 1 1 Two-hybrid
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron genetic 1 1 1 Positive Genetic
KTR6 YPL053C Probable mannosylphosphate transferase genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Negative Genetic
INP54 YOL065C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase physical 1 1 1 Two-hybrid
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors physical 1 1 1 Two-hybrid
NSG1 YHR133C Protein involved in regulation of sterol biosynthesis physical 1 1 1 Two-hybrid
ERG24 YNL280C C-14 sterol reductase physical 1 1 1 Two-hybrid
ERG4 YGL012W C-24(28) sterol reductase physical 1 1 1 Two-hybrid
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
CCW14 YLR390W-A Covalently linked cell wall glycoprotein physical 1 1 1 Two-hybrid
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
ERD2 YBL040C HDEL receptor genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
PCP1 YGR101W Mitochondrial serine protease genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic