Standard name Systematic name Name description Description
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); proposed to stimulate the ATPase and helicase activities of eIF4A synergistically with eIF4G based on sequence similarity with Tif4631p; proposed to be required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; associated with Pab1p-mediated poly(A)-tail stimulated, translation
Visualize the interactome of TIF4632
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.978 0.948 0.930
Cell Periphery NaN NaN 0.059

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 3390

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TIF4632 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PAB1 YER165W Poly(A) binding protein physical 14 5 9 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Co-purification
CDC33 YOL139C Translation initiation factor eIF4E physical 6 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 4 3 4 PCA, PCA, Affinity Capture-Western, Reconstituted Complex
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 3 3 3 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-RNA
TIF2 YJL138C Translation initiation factor eIF4A physical 3 2 3 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 3 2 3 Affinity Capture-MS, PCA, Affinity Capture-MS
TIF1 YKR059W Translation initiation factor eIF4A genetic 3 2 3 Dosage Rescue, Dosage Rescue, Synthetic Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-RNA
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SGN1 YIR001C Cytoplasmic RNA-binding protein physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CDC33 YOL139C Translation initiation factor eIF4E genetic 3 2 2 Dosage Rescue, Dosage Rescue, Phenotypic Suppression
TIF2 YJL138C Translation initiation factor eIF4A genetic 3 2 2 Dosage Rescue, Dosage Rescue, Phenotypic Suppression
SUI1 YNL244C Translation initiation factor eIF1 physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
PRP11 YDL043C Subunit of the SF3a splicing factor complex physical 2 2 2 Two-hybrid, Reconstituted Complex
TIF1 YKR059W Translation initiation factor eIF4A physical 2 2 2 Reconstituted Complex, Affinity Capture-Western
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
KSP1 YHR082C Serine/threonine protein kinase regulation 2 2 1 protein kinase assay evidence, qualitative western immunoblotting evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
SGN1 YIR001C Cytoplasmic RNA-binding protein genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
TIF5 YPR041W Translation initiation factor eIF5 physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Dosage Rescue
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
RPF1 YHR088W Protein involved in assembly and export of the large ribosomal subunit genetic 1 1 1 Dosage Rescue
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly genetic 1 1 1 Dosage Rescue
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Dosage Rescue
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-Western
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Dosage Rescue
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein physical 1 1 1 Reconstituted Complex
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Affinity Capture-MS
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Positive Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 1 1 1 Affinity Capture-MS
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex physical 1 1 1 Two-hybrid
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-MS
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM4 YER112W Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-Western
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Positive Genetic
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Negative Genetic
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase genetic 1 1 1 Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 1 1 1 Affinity Capture-MS
CSI1 YMR025W Subunit of the Cop9 signalosome genetic 1 1 1 Positive Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Positive Genetic
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
SNU71 YGR013W Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Reconstituted Complex
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 genetic 1 1 1 Phenotypic Suppression
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex genetic 1 1 1 Dosage Rescue
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
CBK1 YNL161W Serine/threonine protein kinase of the the RAM signaling network physical 1 1 1 Affinity Capture-MS
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
MAG2 YLR427W Cytoplasmic protein of unknown function physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Co-localization
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
MAG1 YER142C 3-methyl-adenine DNA glycosylase physical 1 1 1 Affinity Capture-MS
RIM11 YMR139W Protein kinase physical 1 1 1 Affinity Capture-MS
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
GFD1 YMR255W Coiled-coiled protein of unknown function physical 1 1 1 PCA
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Positive Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Positive Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Negative Genetic
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 1 1 1 Affinity Capture-MS
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 1 1 1 Affinity Capture-Western
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Dosage Rescue
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Rescue
MUD2 YKL074C Protein involved in early pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 Affinity Capture-MS
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Rescue
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
MSL5 YLR116W Component of commitment complex physical 1 1 1 Affinity Capture-MS
TIF3 YPR163C Translation initiation factor eIF-4B physical 1 1 1 Affinity Capture-Western
TIF3 YPR163C Translation initiation factor eIF-4B genetic 1 1 1 Synthetic Rescue
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 1 1 1 Dosage Rescue
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
GUK1 YDR454C Guanylate kinase genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Dosage Rescue
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SCD6 YPR129W Repressor of translation initiation physical 1 1 1 Reconstituted Complex
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
IRC20 YLR247C E3 ubiquitin ligase and putative helicase physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Dosage Rescue