| PDI1 |
YCL043C |
Protein disulfide isomerase |
genetic |
3 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Synthetic Rescue |
| MKK2 |
YPL140C |
MAPKK involved in the protein kinase C signaling pathway |
genetic |
3 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic |
| CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ECM25 |
YJL201W |
Endocytic site protein required for stress-induced cell elongation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DPC29 |
YGR021W |
Putative mitochondrial protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CUP9 |
YPL177C |
Homeodomain-containing transcriptional repressor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PEX19 |
YDL065C |
Chaperone and import receptor for newly-synthesized class I PMPs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VBA4 |
YDR119W |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MTC5 |
YDR128W |
Subunit of SEACAT, a subcomplex of the SEA complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PEX10 |
YDR265W |
Peroxisomal membrane E3 ubiquitin ligase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| GCG1 |
YER163C |
Gamma-glutamyl cyclotransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YFL040W |
YFL040W |
Putative transporter |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SAP4 |
YGL229C |
Protein required for function of the Sit4p protein phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SUT1 |
YGL162W |
Zn(II)2Cys6 family transcription factor |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| PKP2 |
YGL059W |
Mitochondrial protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| THI4 |
YGR144W |
Thiazole synthase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| GPC1 |
YGR149W |
Glycerophosphocholine acyltransferase (GPCAT) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| PHO81 |
YGR233C |
Cyclin-dependent kinase (CDK) inhibitor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TNA1 |
YGR260W |
High affinity nicotinic acid plasma membrane permease |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MRS3 |
YJL133W |
Iron transporter, mediates Fe2+ transport across inner mito membrane |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RAD7 |
YJR052W |
Nucleotide excision repair (NER) protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| IME1 |
YJR094C |
Master regulator of meiosis that is active only during meiotic events |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| JHD2 |
YJR119C |
JmjC domain family histone demethylase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SDH1 |
YKL148C |
Flavoprotein subunit of succinate dehydrogenase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OAC1 |
YKL120W |
Mitochondrial inner membrane transporter |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| SMF3 |
YLR034C |
Putative divalent metal ion transporter involved in iron homeostasis |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RPS0B |
YLR048W |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| LAM6 |
YLR072W |
Sterol transporter that transfers sterols between membranes |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| YLR177W |
YLR177W |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| SEI1 |
YLR404W |
Seipin involved in lipid droplet (LD) assembly |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PET127 |
YOR017W |
Protein with a role in 5'-end processing of mitochondrial RNAs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SKS1 |
YPL026C |
Putative serine/threonine protein kinase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ERP4 |
YOR016C |
Member of the p24 family involved in ER to Golgi transport |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CHM7 |
YJL049W |
Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| MNN1 |
YER001W |
Alpha-1,3-mannosyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PGA3 |
YML125C |
Putative cytochrome b5 reductase, localized to the plasma membrane |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| PMT1 |
YDL095W |
Protein O-mannosyltransferase of the ER membrane |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| GLO3 |
YER122C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| ROX1 |
YPR065W |
Heme-dependent repressor of hypoxic genes |
genetic |
2 |
1 |
1 |
Phenotypic Enhancement, Phenotypic Enhancement |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
| APL5 |
YPL195W |
Delta adaptin-like subunit of the clathrin associated protein complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM21 |
YIR003W |
Subunit of a complex that associates with actin filaments |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DUG2 |
YBR281C |
Component of glutamine amidotransferase (GATase II) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APE2 |
YKL157W |
Aminopeptidase yscII |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADY3 |
YDL239C |
Protein required for spore wall formation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD6 |
YLR319C |
Actin- and formin-interacting protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CPR7 |
YJR032W |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ECM3 |
YOR092W |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SSO2 |
YMR183C |
Plasma membrane t-SNARE |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR050C |
YCR050C |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP8 |
YDR083W |
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRX16 |
YDR132C |
Protein that associates with the large mitoribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GGA1 |
YDR358W |
Golgi-localized protein with homology to gamma-adaptin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHE10 |
YGL228W |
Protein involved in outer spore wall assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GUP1 |
YGL084C |
Plasma membrane protein involved in remodeling GPI anchors |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCY1 |
YGL083W |
Putative kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDS23 |
YGL056C |
Protein involved in cell separation during budding |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIM8 |
YGL045W |
Protein involved in proteolytic activation of Rim101p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR026W |
YGR026W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL26B |
YGR034W |
Ribosomal 60S subunit protein L26B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUC2 |
YIL162W |
Invertase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCI37 |
YIL077C |
Protein that associates with the large mitoribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IMA5 |
YJL216C |
Alpha-glucosidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YJL163C |
YJL163C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP185 |
YJL098W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HUL4 |
YJR036C |
Protein with similarity to hect domain E3 ubiquitin-protein ligases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NNR2 |
YKL151C |
Widely-conserved NADHX dehydratase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SFK1 |
YKL051W |
Protein that regulates phospholipid asymmetry at plasma membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STM1 |
YLR150W |
Protein required for optimal translation under nutrient stress |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STB4 |
YMR019W |
Putative transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MKS1 |
YNL076W |
Pleiotropic negative transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HOL1 |
YNR055C |
Putative transporter in the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMF1 |
YOL122C |
Divalent metal ion transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SFL1 |
YOR140W |
Transcriptional repressor and activator |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MPC54 |
YOR177C |
Component of the meiotic outer plaque |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MUM3 |
YOR298W |
Protein of unknown function involved in outer spore wall organization |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAR1 |
YPL239W |
Nucleocytoplasmic shuttling assembly chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SVS1 |
YPL163C |
Cell wall and vacuolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PET20 |
YPL159C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ISU1 |
YPL135W |
Conserved protein of the mitochondrial matrix |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MET12 |
YPL023C |
Protein with MTHFR activity in vitro |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAR2 |
YJL034W |
ATPase involved in protein import into the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HER2 |
YMR293C |
Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SLM3 |
YDL033C |
tRNA-specific 2-thiouridylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HAP4 |
YKL109W |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YNR021W |
YNR021W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RFM1 |
YOR279C |
Component of the Sum1p-Rfm1p-Hst1p complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ULA1 |
YPL003W |
Protein that activates Rub1p (NEDD8) before neddylation |
genetic |
1 |
1 |
1 |
Positive Genetic |
| USV1 |
YPL230W |
Putative transcription factor containing a C2H2 zinc finger |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PAN1 |
YIR006C |
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED11 |
YMR112C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI12 |
YMR281W |
ER membrane protein involved in the second step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VFA1 |
YER128W |
Protein that interacts with Vps4p and has a role in vacuolar sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIM21 |
YGR033C |
Nonessential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLX1 |
YIL134W |
Mitochondrial flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NRE1 |
YIR035C |
Putative cytoplasmic short-chain dehydrogenase/reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SYM1 |
YLR251W |
Protein required for ethanol metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOK2 |
YMR016C |
Nuclear protein that negatively regulates pseudohyphal differentiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUB1 |
YMR039C |
Transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YNL034W |
YNL034W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SER1 |
YOR184W |
3-phosphoserine aminotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMP52 |
YER004W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APE4 |
YHR113W |
Cytoplasmic aspartyl aminopeptidase with possible vacuole function |
physical |
1 |
1 |
1 |
Two-hybrid |
| EEB1 |
YPL095C |
Acyl-coenzymeA:ethanol O-acyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DLD1 |
YDL174C |
Major mitochondrial D-lactate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG40 |
YOR152C |
Autophagy receptor with a role in endoplasmic reticulum degradation |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EMC3 |
YKL207W |
Member of conserved ER transmembrane complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
