| CDC42 |
YLR229C |
Small rho-like GTPase |
physical |
11 |
3 |
10 |
Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Reconstituted Complex |
| GIC2 |
YDR309C |
Rho-family GTPase interacting protein and Cdc42p effector |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
6 |
4 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Dosage Rescue, Dosage Rescue, Phenotypic Suppression, Synthetic Lethality |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
4 |
3 |
4 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
4 |
3 |
4 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
| BUB2 |
YMR055C |
Mitotic exit network regulator |
physical |
4 |
2 |
3 |
Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
3 |
2 |
3 |
Negative Genetic, Dosage Rescue, Negative Genetic |
| RSR1 |
YGR152C |
Ras-type GTPase |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Dosage Rescue, Dosage Rescue |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
3 |
3 |
2 |
Synthetic Haploinsufficiency, Positive Genetic, Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
physical |
3 |
3 |
2 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
3 |
3 |
2 |
Phenotypic Suppression, Phenotypic Enhancement, Dosage Growth Defect |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
physical |
3 |
2 |
2 |
Two-hybrid, Two-hybrid, Reconstituted Complex |
| MLF3 |
YNL074C |
Serine-rich protein of unknown function |
genetic |
3 |
2 |
1 |
Synthetic Growth Defect, Dosage Rescue, Dosage Rescue |
| VHS2 |
YIL135C |
Regulator of septin dynamics |
genetic |
3 |
2 |
1 |
Synthetic Growth Defect, Dosage Rescue, Dosage Rescue |
| AXL2 |
YIL140W |
Integral plasma membrane protein |
genetic |
2 |
2 |
2 |
Dosage Rescue, Synthetic Lethality |
| CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Dosage Rescue |
| STE20 |
YHL007C |
Cdc42p-activated signal transducing kinase |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Dosage Rescue |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
physical |
2 |
2 |
1 |
Reconstituted Complex, Two-hybrid |
| LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
2 |
2 |
1 |
Dosage Rescue, Synthetic Rescue |
| ENT1 |
YDL161W |
Epsin-like protein involved in endocytosis and actin patch assembly |
genetic |
2 |
2 |
1 |
Dosage Rescue, Synthetic Growth Defect |
| GIC2 |
YDR309C |
Rho-family GTPase interacting protein and Cdc42p effector |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
| HOS1 |
YPR068C |
Class I histone deacetylase (HDAC) family member |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
| XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| STB1 |
YNL309W |
Protein with role in regulation of MBF-specific transcription at Start |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| YAP5 |
YIR018W |
Basic leucine zipper (bZIP) iron-sensing transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SWI6 |
YLR182W |
Transcription cofactor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CLF1 |
YLR117C |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| GCD1 |
YOR260W |
Gamma subunit of the translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| AOS1 |
YPR180W |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APL1 |
YJR005W |
Beta-adaptin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
physical |
1 |
1 |
1 |
Two-hybrid |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BNI1 |
YNL271C |
Formin |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| FDH1 |
YOR388C |
NAD(+)-dependent formate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DMA2 |
YNL116W |
Ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CYC8 |
YBR112C |
General transcriptional co-repressor |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
physical |
1 |
1 |
1 |
Two-hybrid |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLN2 |
YPL256C |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| APE2 |
YKL157W |
Aminopeptidase yscII |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
physical |
1 |
1 |
1 |
Two-hybrid |
| BNI4 |
YNL233W |
Targeting subunit for Glc7p protein phosphatase |
physical |
1 |
1 |
1 |
Two-hybrid |
| COG4 |
YPR105C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD5 |
YCR038C |
GTP/GDP exchange factor for Rsr1p (Bud1p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BNI5 |
YNL166C |
Linker protein responsible for recruitment of myosin to the bud neck |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BUD2 |
YKL092C |
GTPase activating factor for Rsr1p/Bud1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TEM1 |
YML064C |
GTPase involved in initiation of Mitotic Exit Network (MEN) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| GIC1 |
YHR061C |
Rho-family GTPase interacting protein and Cdc42p effector |
physical |
1 |
1 |
1 |
Two-hybrid |
| HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
physical |
1 |
1 |
1 |
Two-hybrid |
| STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
physical |
1 |
1 |
1 |
Two-hybrid |
| RRP14 |
YKL082C |
Essential protein, constituent of 66S pre-ribosomal particles |
physical |
1 |
1 |
1 |
Two-hybrid |
| ZDS1 |
YMR273C |
Protein with a role in regulating Swe1p-dependent polarized growth |
physical |
1 |
1 |
1 |
Two-hybrid |
| ZDS2 |
YML109W |
Protein with a role in regulating Swe1p-dependent polarized growth |
physical |
1 |
1 |
1 |
Two-hybrid |
| MRP13 |
YGR084C |
Mitochondrial ribosomal protein of the small subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HTA2 |
YBL003C |
Histone H2A |
physical |
1 |
1 |
1 |
Two-hybrid |
| HTB2 |
YBL002W |
Histone H2B |
physical |
1 |
1 |
1 |
Two-hybrid |
| HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Two-hybrid |
| HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Two-hybrid |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
physical |
1 |
1 |
1 |
Two-hybrid |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PCL1 |
YNL289W |
Cyclin, interacts with cyclin-dependent kinase Pho85p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PCL2 |
YDL127W |
Cyclin, interacts with cyclin-dependent kinase Pho85p |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| TUP1 |
YCR084C |
General repressor of transcription in complex with Cyc8p |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SKG6 |
YHR149C |
Integral membrane protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| TOS2 |
YGR221C |
Protein involved in localization of Cdc24p to the site of bud growth |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| MSB2 |
YGR014W |
Mucin family member involved in various signaling pathways |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| MSB1 |
YOR188W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| MSB3 |
YNL293W |
Rab GTPase-activating protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| MSB4 |
YOL112W |
GTPase-activating protein of the Ras superfamily |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| POP5 |
YAL033W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPL15A |
YLR029C |
Ribosomal 60S subunit protein L15A |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KAP104 |
YBR017C |
Transportin or cytosolic karyopherin beta 2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YDR415C |
YDR415C |
Putative aminopeptidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRB6 |
YBR253W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP6 |
YGR030C |
Subunit of RNase MRP, nuclear RNase P and telomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TFA1 |
YKL028W |
TFIIE large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC19 |
YNL113W |
RNA polymerase subunit AC19 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN8 |
YOR261C |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP12 |
YPL012W |
Protein required for export of the ribosomal subunits |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YTH1 |
YPR107C |
Essential RNA-binding component of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GNA1 |
YFL017C |
Glucosamine-6-phosphate acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STS1 |
YIR011C |
Protein required for localizing proteasomes to the nucleus |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NTR2 |
YKR022C |
Essential protein that forms a dimer with Ntr1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSL1 |
YLR005W |
Subunit of the core form of RNA polymerase transcription factor TFIIH |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MYO4 |
YAL029C |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTF2 |
YDL044C |
Mitochondrial protein that interacts with mitochondrial RNA polymerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MFG1 |
YDL233W |
Regulator of filamentous growth |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOR1 |
YDR366C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL12B |
YDR418W |
Ribosomal 60S subunit protein L12B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS52 |
YDR484W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GYP8 |
YFL027C |
GTPase-activating protein for yeast Rab family members |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR161W-C |
YGR161W-C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JSN1 |
YJR091C |
Member of the Puf family of RNA-binding proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAU16 |
YKL224C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NTE1 |
YML059C |
Serine esterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YTA12 |
YMR089C |
Mitochondrial inner membrane m-AAA protease component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNO4 |
YMR322C |
Possible chaperone and cysteine protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAX1 |
YOR301W |
Protein involved in establishing bud site selection |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
| DFG5 |
YMR238W |
Putative mannosidase |
physical |
1 |
1 |
1 |
Two-hybrid |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FCY22 |
YER060W-A |
Putative purine-cytosine permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLX1 |
YIL134W |
Mitochondrial flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
