Standard name Systematic name Name description Description
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
Visualize the interactome of MSS51
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.925 0.957 0.844
Nuc Periphery 0.050 NaN 0.075
Nucleolus 0.101 0.064 0.055
Vac/Vac Memb 0.116 0.080 NaN
Golgi NaN NaN 0.053
Peroxisome NaN NaN 0.103

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 4800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MSS51 5 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
COX1 Q0045 Subunit I of cytochrome c oxidase (Complex IV) physical 11 2 10 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
COA1 YIL157C Mitochondrial inner membrane protein physical 9 3 7 Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Proximity Label-MS
COX14 YML129C Mitochondrial cytochrome c oxidase (complex IV) assembly factor physical 9 1 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly physical 9 1 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SHY1 YGR112W Mitochondrial inner membrane protein required for complex IV assembly physical 9 3 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Proximity Label-MS
SSC1 YJR045C Hsp70 family ATPase physical 7 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
COX2 Q0250 Subunit II of cytochrome c oxidase (Complex IV) physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
COA1 YIL157C Mitochondrial inner membrane protein genetic 4 2 2 Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Dosage Rescue
COX3 Q0275 Subunit III of cytochrome c oxidase (Complex IV) physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
SHY1 YGR112W Mitochondrial inner membrane protein required for complex IV assembly genetic 3 2 3 Dosage Rescue, Synthetic Rescue, Dosage Rescue
OMS1 YDR316W Protein integral to the mitochondrial membrane physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
COA2 YPL189C-A Cytochrome oxidase assembly factor genetic 3 2 1 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
ATP6 Q0085 Subunit a of the F0 sector of mitochondrial F1F0 ATP synthase physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
OLI1 Q0130 F0-ATP synthase subunit c (ATPase-associated proteolipid) physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
TIM50 YPL063W Essential component of the TIM23 complex physical 2 2 2 Affinity Capture-Western, Proximity Label-MS
ATP8 Q0080 Subunit 8 of the F0 sector of mitochondrial F1F0 ATP synthase physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
COB Q0105 Cytochrome b physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
YPK1 YKL126W S/T protein kinase genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 2 2 1 Phenotypic Suppression, Dosage Lethality
COX10 YPL172C Heme A:farnesyltransferase genetic 2 2 1 Synthetic Rescue, Phenotypic Enhancement
IRA2 YOL081W GTPase-activating protein genetic 2 1 1 Negative Genetic, Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 2 1 1 Negative Genetic, Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 2 1 1 Negative Genetic, Negative Genetic
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 2 1 1 Negative Genetic, Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ARP3 YJR065C Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
COX4 YGL187C Subunit IV of cytochrome c oxidase physical 1 1 1 Affinity Capture-Western
COX5A YNL052W Subunit Va of cytochrome c oxidase physical 1 1 1 Affinity Capture-MS
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) physical 1 1 1 Affinity Capture-MS
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase genetic 1 1 1 Negative Genetic
MRPL36 YBR122C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-Western
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Co-fractionation
MRP51 YPL118W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-Western
CCM1 YGR150C Mitochondrial 15S rRNA-binding protein physical 1 1 1 Proximity Label-MS
MLC1 YGL106W Essential light chain for Myo1p physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Affinity Capture-MS
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
GPT2 YKR067W Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Negative Genetic
CRN1 YLR429W Coronin physical 1 1 1 Affinity Capture-MS
ACO1 YLR304C Aconitase physical 1 1 1 Affinity Capture-Western
LSP1 YPL004C Eisosome core component physical 1 1 1 Affinity Capture-MS
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Dosage Lethality
ECM10 YEL030W Heat shock protein of the Hsp70 family physical 1 1 1 Affinity Capture-MS
CBP3 YPL215W Mitochondrial protein required for assembly of cytochrome bc1 complex physical 1 1 1 Proximity Label-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
DUF1 YOL087C Ubiquitin-binding protein of unknown function genetic 1 1 1 Negative Genetic
MDJ1 YFL016C Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity physical 1 1 1 Affinity Capture-Western
ATP5 YDR298C Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-Western
ATP5 YDR298C Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
ATG16 YMR159C Conserved protein involved in autophagy genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
MRX21 YPR011C Mitochondrial transporter physical 1 1 1 Proximity Label-MS
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
COX1 Q0045 Subunit I of cytochrome c oxidase (Complex IV) genetic 1 1 1 Synthetic Rescue
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Dosage Growth Defect
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
COX15 YER141W Heme a synthase physical 1 1 1 Proximity Label-MS
MDJ2 YNL328C Constituent of the mitochondrial import motor physical 1 1 1 Proximity Label-MS
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor physical 1 1 1 Proximity Label-MS
CBS1 YDL069C Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Phenotypic Suppression
INA17 YPL099C F1F0 ATPase synthase peripheral stalk assembly factor physical 1 1 1 Proximity Label-MS
SAC6 YDR129C Fimbrin, actin-bundling protein physical 1 1 1 Affinity Capture-MS
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-MS
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
PET54 YGR222W Mitochondrial inner membrane protein physical 1 1 1 Two-hybrid
PET54 YGR222W Mitochondrial inner membrane protein genetic 1 1 1 Phenotypic Suppression
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles physical 1 1 1 Affinity Capture-MS
PET309 YLR067C Specific translational activator for the COX1 mRNA physical 1 1 1 Affinity Capture-Western
PET309 YLR067C Specific translational activator for the COX1 mRNA genetic 1 1 1 Synthetic Growth Defect
MSW1 YDR268W Mitochondrial tryptophanyl-tRNA synthetase physical 1 1 1 Proximity Label-MS
NAT2 YGR147C Protein of unknown function physical 1 1 1 Proximity Label-MS
NDE1 YMR145C Mitochondrial external NADH dehydrogenase physical 1 1 1 Proximity Label-MS
ODC1 YPL134C Mitochondrial inner membrane transporter physical 1 1 1 Proximity Label-MS
OXA1 YER154W Mitochondrial inner membrane insertase physical 1 1 1 Proximity Label-MS
PET111 YMR257C Mitochondrial translational activator specific for the COX2 mRNA physical 1 1 1 Proximity Label-MS
PET111 YMR257C Mitochondrial translational activator specific for the COX2 mRNA genetic 1 1 1 Phenotypic Suppression
PET112 YBL080C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex physical 1 1 1 Proximity Label-MS
RIM2 YBR192W Mitochondrial pyrimidine nucleotide transporter physical 1 1 1 Proximity Label-MS
SAL1 YNL083W ADP/ATP transporter physical 1 1 1 Proximity Label-MS
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane physical 1 1 1 Proximity Label-MS
SHE9 YDR393W Protein required for normal mitochondrial morphology physical 1 1 1 Proximity Label-MS
TAM41 YGR046W Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase) physical 1 1 1 Proximity Label-MS
YLH47 YPR125W Mitochondrial inner membrane protein physical 1 1 1 Proximity Label-MS
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component physical 1 1 1 Proximity Label-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Positive Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Negative Genetic
UGA1 YGR019W Gamma-aminobutyrate (GABA) transaminase genetic 1 1 1 Negative Genetic
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
REG2 YBR050C Regulatory subunit of the Glc7p type-1 protein phosphatase genetic 1 1 1 Negative Genetic
VBA2 YBR293W Permease of basic amino acids in the vacuolar membrane genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
YER187W YER187W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
SPC2 YML055W Subunit of signal peptidase complex genetic 1 1 1 Negative Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
NRK1 YNL129W Nicotinamide riboside kinase genetic 1 1 1 Negative Genetic
SOL1 YNR034W Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
PDR10 YOR328W ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Synthetic Growth Defect
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Phenotypic Suppression
ABP140 YOR239W AdoMet-dependent tRNA methyltransferase and actin binding protein genetic 1 1 1 Negative Genetic
AIM39 YOL053W Protein of unknown function physical 1 1 1 Proximity Label-MS
MRX9 YDL027C Protein that associates with mitochondrial ribosome physical 1 1 1 Proximity Label-MS
COX10 YPL172C Heme A:farnesyltransferase physical 1 1 1 Proximity Label-MS
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor physical 1 1 1 Proximity Label-MS
COX11 YPL132W Protein required for delivery of copper to Cox1p physical 1 1 1 Proximity Label-MS
EAR1 YMR171C Specificity factor required for Rsp5p-dependent ubiquitination genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
FMP25 YLR077W Protein required for assembly of respiratory complex III physical 1 1 1 Proximity Label-MS
ARO7 YPR060C Chorismate mutase genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
MIC60 YKR016W Component of the MICOS complex physical 1 1 1 Affinity Capture-MS
MRX19 YDL183C Protein that may form an active mitochondrial KHE system physical 1 1 1 Proximity Label-MS
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-MS
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
MRX20 YFR045W Putative mitochondrial transport protein physical 1 1 1 Proximity Label-MS
MRX4 YPL168W Protein that associates with mitochondrial ribosome physical 1 1 1 Proximity Label-MS
MRX15 YNR040W Membrane-associated mitoribosome receptor physical 1 1 1 Proximity Label-MS
MMT1 YMR177W Putative metal transporter involved in mitochondrial iron accumulation physical 1 1 1 Proximity Label-MS