Standard name Systematic name Name description Description
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)
Visualize the interactome of NSP1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm NaN 0.083 0.050
Nuc Periphery NaN 0.556 0.745
Vac/Vac Memb NaN 0.639 0.213
Mito NaN NaN 0.054
Nucleolus NaN NaN 0.138

GFP localization & abundance

GFP localization GFP abundance
nuclear periphery 2400

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
NSP1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
NUP82 YJL061W Linker nucleoporin component of the nuclear pore complex (NPC) physical 24 6 16 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, PCA, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Far Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex physical 20 6 15 Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-MS, Affinity Capture-MS, Far Western, Far Western, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Affinity Capture-MS
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex physical 17 3 11 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
NUP49 YGL172W FG-nucleoporin component of central core of the nuclear pore complex physical 15 7 12 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification, Co-purification, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-MS, Affinity Capture-MS, Far Western, Affinity Capture-MS, Affinity Capture-MS
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) physical 14 5 10 Affinity Capture-MS, Reconstituted Complex, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Far Western, Affinity Capture-MS, Affinity Capture-MS
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex physical 7 3 6 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
KAP95 YLR347C Karyopherin beta physical 5 2 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export physical 5 4 4 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, FRET, Affinity Capture-MS
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex physical 4 2 3 Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex
ATG8 YBL078C Ub-like protein physical 4 2 2 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
KAP123 YER110C Karyopherin beta physical 3 3 3 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
NUP49 YGL172W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
NTF2 YER009W Nuclear envelope protein physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
SAC3 YDR159W mRNA export factor physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex physical 2 2 2 Co-fractionation, Affinity Capture-MS
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 2 2 2 Synthetic Lethality, Negative Genetic
GSP1 YLR293C Ran GTPase physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
MTR2 YKL186C mRNA transport regulator physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MRPL8 YJL063C Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MRPL15 YLR312W-A Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MRPL3 YMR024W Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
RAD53 YPL153C DNA damage response kinase regulation 1 1 1 protein kinase assay evidence
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit physical 1 1 1 Reconstituted Complex
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
ECM1 YAL059W Pre-ribosomal factor involved in 60S ribosomal protein subunit export genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Negative Genetic
YML6 YML025C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
RRP12 YPL012W Protein required for export of the ribosomal subunits physical 1 1 1 Reconstituted Complex
SXM1 YDR395W Nuclear transport factor (karyopherin) physical 1 1 1 Affinity Capture-Western
URB1 YKL014C Protein required for the normal accumulation of 25S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Lethality
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex physical 1 1 1 Affinity Capture-MS
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport physical 1 1 1 PCA
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Synthetic Lethality
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Affinity Capture-MS
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex physical 1 1 1 Affinity Capture-MS
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex genetic 1 1 1 Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
NUP42 YDR192C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP42 YDR192C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes physical 1 1 1 Affinity Capture-MS
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Affinity Capture-MS
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Two-hybrid
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 PCA
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) physical 1 1 1 Reconstituted Complex
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Affinity Capture-MS
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
RPB4 YJL140W RNA polymerase II subunit B32 genetic 1 1 1 Dosage Rescue
PUS1 YPL212C tRNA:pseudouridine synthase genetic 1 1 1 Synthetic Lethality
RNQ1 YCL028W [PIN(+)] prion genetic 1 1 1 Dosage Rescue
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Positive Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Positive Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
POM33 YLL023C Transmembrane nucleoporin genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
YLR460C YLR460C Member of the quinone oxidoreductase family genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
YMR181C YMR181C Protein of unknown function genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Negative Genetic
SFG1 YOR315W Nuclear protein putative transcription factor genetic 1 1 1 Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Two-hybrid
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 1 1 1 Positive Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein genetic 1 1 1 Synthetic Lethality
KAP122 YGL016W Karyopherin beta physical 1 1 1 Reconstituted Complex
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export physical 1 1 1 Affinity Capture-MS
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
ARE1 YCR048W Acyl-CoA:sterol acyltransferase physical 1 1 1 Two-hybrid
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-MS
CLB2 YPR119W B-type cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-MS
LOS1 YKL205W Nuclear pore protein physical 1 1 1 Affinity Capture-Western
LOS1 YKL205W Nuclear pore protein genetic 1 1 1 Synthetic Lethality
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Negative Genetic
ASM4 YDL088C FG-nucleoporin component of central core of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
ASM4 YDL088C FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NDC1 YML031W Subunit of the transmembrane ring of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
HOT1 YMR172W Transcription factor for glycerol biosynthetic genes physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Positive Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex physical 1 1 1 Affinity Capture-MS
IOC2 YLR095C Subunit of the Isw1b complex genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein physical 1 1 1 PCA
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 1 1 1 Negative Genetic
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 1 1 1 Two-hybrid
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
CSA1 YPR174C Protein of unknown function genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
GAS4 YOL132W 1,3-beta-glucanosyltransferase physical 1 1 1 PCA
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic