GEnome-wide tool for Multi-scale Modeling
data Extraction and Representation
for Saccharomyces cerevisiae

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.

Standard name	Systematic name	Name description	Type	#Experiments	#Methods	#Publications	Evidence
SEC3	YER008C	Subunit of the exocyst complex	physical	15	6	8	Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Two-hybrid, Two-hybrid, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex
SEC8	YPR055W	Essential 121 kDa subunit of the exocyst complex	physical	11	5	10	Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Reconstituted Complex
SEC6	YIL068C	Essential 88kDa subunit of the exocyst complex	physical	11	6	8	Reconstituted Complex, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SEC10	YLR166C	Essential 100kDa subunit of the exocyst complex	physical	10	5	7	Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	physical	9	4	7	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
SEC4	YFL005W	Rab family GTPase	genetic	9	3	7	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue
EXO70	YJL085W	Subunit of the exocyst complex	physical	8	4	6	Reconstituted Complex, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SEC1	YDR164C	Sm-like protein involved in docking and fusion of exocytic vesicles	genetic	6	2	5	Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Dosage Rescue
SEC6	YIL068C	Essential 88kDa subunit of the exocyst complex	genetic	6	3	4	Phenotypic Suppression, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SEC15	YGL233W	Essential 113 kDa subunit of the exocyst complex	physical	5	3	5	Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
SEC10	YLR166C	Essential 100kDa subunit of the exocyst complex	genetic	5	3	3	Dosage Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SEC15	YGL233W	Essential 113 kDa subunit of the exocyst complex	genetic	5	2	3	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SEC3	YER008C	Subunit of the exocyst complex	genetic	4	3	3	Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic
SEC9	YGR009C	t-SNARE protein required for secretory vesicle-plasma membrane fusion	genetic	4	3	3	Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic
SEC2	YNL272C	Guanyl-nucleotide exchange factor for the small G-protein Sec4p	genetic	4	2	3	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic
SEC8	YPR055W	Essential 121 kDa subunit of the exocyst complex	genetic	4	2	2	Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SEC5	YDR166C	Essential 107kDa subunit of the exocyst complex	physical	3	2	3	Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
MSO1	YNR049C	Lipid-interacting protein in SNARE complex assembly machinery	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic
MYO2	YOR326W	Type V myosin motor involved in actin-based transport of cargos	genetic	3	1	3	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
BEM1	YBR200W	Protein containing SH3-domains	physical	3	3	2	Co-purification, Reconstituted Complex, PCA
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	genetic	3	2	2	Dosage Rescue, Negative Genetic, Negative Genetic
EXO70	YJL085W	Subunit of the exocyst complex	genetic	3	2	2	Negative Genetic, Negative Genetic, Synthetic Growth Defect
GDI1	YER136W	GDP dissociation inhibitor	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SSO2	YMR183C	Plasma membrane t-SNARE	genetic	2	2	2	Dosage Rescue, Negative Genetic
SGS1	YMR190C	RecQ family nucleolar DNA helicase	genetic	2	2	2	Phenotypic Enhancement, Negative Genetic
CDC42	YLR229C	Small rho-like GTPase	genetic	2	1	2	Synthetic Lethality, Synthetic Lethality
DHH1	YDL160C	Cytoplasmic DEAD-box helicase and mRNA decapping activator	physical	2	1	2	Affinity Capture-RNA, Affinity Capture-RNA
SRO7	YPR032W	Effector of Rab GTPase Sec4p	genetic	2	1	2	Dosage Rescue, Dosage Rescue
BOI1	YBL085W	Protein involved in polar growth, functionally redundant with Boi2p	physical	2	2	1	PCA, Reconstituted Complex
BEM2	YER155C	Rho GTPase activating protein (RhoGAP)	genetic	2	1	1	Negative Genetic, Negative Genetic
SNC2	YOR327C	Vesicle membrane receptor protein (v-SNARE)	genetic	2	1	1	Negative Genetic, Negative Genetic
RHO3	YIL118W	Non-essential small GTPase of the Rho/Rac family of Ras-like proteins	genetic	2	1	1	Negative Genetic, Negative Genetic
RPB3	YIL021W	RNA polymerase II third largest subunit B44	physical	1	1	1	Affinity Capture-MS
RVB2	YPL235W	ATP-dependent DNA helicase, also known as reptin	physical	1	1	1	Affinity Capture-MS
NOC3	YLR002C	Subunit of a nuclear complex with Noc2p and pre-replicative complexes	genetic	1	1	1	Negative Genetic
KES1	YPL145C	Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger	genetic	1	1	1	Dosage Growth Defect
NOP1	YDL014W	Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus	genetic	1	1	1	Synthetic Lethality
RPA49	YNL248C	RNA polymerase I subunit A49	genetic	1	1	1	Synthetic Growth Defect
MED4	YOR174W	Subunit of the RNA polymerase II mediator complex	physical	1	1	1	Affinity Capture-MS
GCD1	YOR260W	Gamma subunit of the translation initiation factor eIF2B	genetic	1	1	1	Negative Genetic
ACT1	YFL039C	Actin, structural protein in cytoskeleton	genetic	1	1	1	Negative Genetic
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	physical	1	1	1	Affinity Capture-RNA
NAB2	YGL122C	Nuclear polyadenylated RNA-binding protein	physical	1	1	1	Affinity Capture-RNA
EFT2	YDR385W	Elongation factor 2 (EF-2), also encoded by EFT1	physical	1	1	1	Affinity Capture-MS
BOI2	YER114C	Protein involved in polar growth	physical	1	1	1	PCA
BNI1	YNL271C	Formin	physical	1	1	1	PCA
CEG1	YGL130W	Guanylyltransferase involved in mRNA 5' capping	genetic	1	1	1	Negative Genetic
AVO1	YOL078W	Component of the membrane-bound TORC2 complex	genetic	1	1	1	Negative Genetic
COX4	YGL187C	Subunit IV of cytochrome c oxidase	genetic	1	1	1	Negative Genetic
DCP1	YOL149W	Subunit of the Dcp1p-Dcp2p decapping enzyme complex	genetic	1	1	1	Negative Genetic
DCP2	YNL118C	Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex	genetic	1	1	1	Negative Genetic
EMG1	YLR186W	Methyltransferase for rRNA	genetic	1	1	1	Negative Genetic
FRS1	YLR060W	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase	genetic	1	1	1	Negative Genetic
ISW1	YBR245C	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers	physical	1	1	1	Affinity Capture-RNA
LCB1	YMR296C	Component of serine palmitoyltransferase	genetic	1	1	1	Negative Genetic
LSM2	YBL026W	Lsm (Like Sm) protein	physical	1	1	1	Two-hybrid
ENO2	YHR174W	Enolase II, a phosphopyruvate hydratase	physical	1	1	1	Affinity Capture-MS
MED6	YHR058C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
HRR25	YPL204W	Conserved casein kinase, monopolin subunit	genetic	1	1	1	Negative Genetic
MYO2	YOR326W	Type V myosin motor involved in actin-based transport of cargos	physical	1	1	1	Affinity Capture-Western
NAB3	YPL190C	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p)	genetic	1	1	1	Negative Genetic
PUB1	YNL016W	Poly (A)+ RNA-binding protein	physical	1	1	1	Affinity Capture-MS
NOP14	YDL148C	Nucleolar protein	genetic	1	1	1	Negative Genetic
OSH2	YDL019C	Member of an oxysterol-binding protein family with seven members	genetic	1	1	1	Dosage Growth Defect
RSE1	YML049C	Protein involved in pre-mRNA splicing	genetic	1	1	1	Negative Genetic
MGA2	YIR033W	ER membrane protein involved in regulation of OLE1 transcription	genetic	1	1	1	Negative Genetic
SCJ1	YMR214W	One of several homologs of bacterial chaperone DnaJ	physical	1	1	1	Affinity Capture-MS
DRS2	YAL026C	Trans-golgi network aminophospholipid translocase (flippase)	genetic	1	1	1	Negative Genetic
PUF3	YLL013C	Protein of the mitochondrial outer surface	physical	1	1	1	Affinity Capture-RNA
RVS161	YCR009C	Amphiphysin-like lipid raft protein	genetic	1	1	1	Phenotypic Suppression
ERG27	YLR100W	3-keto sterol reductase	genetic	1	1	1	Negative Genetic
SEC18	YBR080C	AAA ATPase and SNARE disassembly chaperone	genetic	1	1	1	Phenotypic Suppression
PBR1	YNL181W	Putative oxidoreductase	genetic	1	1	1	Positive Genetic
MRS6	YOR370C	Rab escort protein	genetic	1	1	1	Negative Genetic
RSP5	YER125W	NEDD4 family E3 ubiquitin ligase	genetic	1	1	1	Negative Genetic
IPA1	YJR141W	Protein implicated in pre-mRNA processing and proteasomal degradation	genetic	1	1	1	Negative Genetic
RVS167	YDR388W	Calmodulin-binding actin-associated protein	genetic	1	1	1	Synthetic Growth Defect
BTN2	YGR142W	v-SNARE binding protein	genetic	1	1	1	Negative Genetic
MOB2	YFL034C-B	Activator of Cbk1p kinase	genetic	1	1	1	Negative Genetic
HSP10	YOR020C	Mitochondrial matrix co-chaperonin	genetic	1	1	1	Negative Genetic
COG1	YGL223C	Essential component of the conserved oligomeric Golgi complex	genetic	1	1	1	Synthetic Growth Defect
COG6	YNL041C	Component of the conserved oligomeric Golgi complex	genetic	1	1	1	Negative Genetic
DCD1	YHR144C	Deoxycytidine monophosphate (dCMP) deaminase	genetic	1	1	1	Negative Genetic
PAN1	YIR006C	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p	genetic	1	1	1	Negative Genetic
SBH1	YER087C-B	Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p)	genetic	1	1	1	Dosage Rescue
SEC22	YLR268W	R-SNARE protein	physical	1	1	1	Reconstituted Complex
TIF2	YJL138C	Translation initiation factor eIF4A	physical	1	1	1	Affinity Capture-MS
YPR114W	YPR114W	Protein distantly similar to ceramide synthases, Lag1p and Lac1p	physical	1	1	1	Affinity Capture-MS
SSB1	YDL229W	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone	physical	1	1	1	Affinity Capture-MS
YHR020W	YHR020W	Prolyl-tRNA synthetase	physical	1	1	1	Affinity Capture-MS
SSA1	YAL005C	ATPase involved in protein folding and NLS-directed nuclear transport	physical	1	1	1	Affinity Capture-MS
SSA2	YLL024C	HSP70 family ATP-binding protein	physical	1	1	1	Affinity Capture-MS
TCB2	YNL087W	ER protein involved in ER-plasma membrane tethering	physical	1	1	1	Affinity Capture-MS
SNC2	YOR327C	Vesicle membrane receptor protein (v-SNARE)	physical	1	1	1	Reconstituted Complex
SSD1	YDR293C	Translational repressor	physical	1	1	1	Affinity Capture-RNA
SEC61	YLR378C	Conserved ER protein translocation channel	genetic	1	1	1	Dosage Rescue
SSO1	YPL232W	Plasma membrane t-SNARE	genetic	1	1	1	Dosage Rescue
YPT1	YFL038C	Rab family GTPase	genetic	1	1	1	Synthetic Lethality
SSS1	YDR086C	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p)	genetic	1	1	1	Dosage Rescue
SLT2	YHR030C	Serine/threonine MAP kinase	genetic	1	1	1	Synthetic Lethality
SRO77	YBL106C	Protein with roles in exocytosis and cation homeostasis	genetic	1	1	1	Negative Genetic
VPS27	YNR006W	Endosomal protein that forms a complex with Hse1p	genetic	1	1	1	Negative Genetic
YCK2	YNL154C	Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform	genetic	1	1	1	Synthetic Growth Defect
UTP5	YDR398W	Subunit of U3-containing Small Subunit (SSU) processome complex	genetic	1	1	1	Negative Genetic
STT3	YGL022W	Catalytic subunit of the oligosaccharyltransferase complex of the ER l	genetic	1	1	1	Negative Genetic
SSL1	YLR005W	Subunit of the core form of RNA polymerase transcription factor TFIIH	genetic	1	1	1	Negative Genetic
UTP13	YLR222C	Nucleolar protein	genetic	1	1	1	Negative Genetic
ULP1	YPL020C	Protease that specifically cleaves Smt3p protein conjugates	genetic	1	1	1	Negative Genetic
SUA7	YPR086W	Transcription factor TFIIB	genetic	1	1	1	Negative Genetic
SFA1	YDL168W	Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase	genetic	1	1	1	Negative Genetic
UGA4	YDL210W	GABA (gamma-aminobutyrate) permease	genetic	1	1	1	Negative Genetic
YNL108C	YNL108C	Protein phosphatase	genetic	1	1	1	Negative Genetic
YLF2	YHL014C	Protein of unknown function	genetic	1	1	1	Negative Genetic
YMR272W-B	YMR272W-B	Protein of unknown function	genetic	1	1	1	Negative Genetic
SLA2	YNL243W	Adaptor protein that links actin to clathrin and endocytosis	genetic	1	1	1	Negative Genetic
YKU80	YMR106C	Subunit of telomeric Ku complex (Yku70p-Yku80p)	genetic	1	1	1	Phenotypic Enhancement
MPT5	YGL178W	mRNA-binding protein of the PUF family	physical	1	1	1	Affinity Capture-RNA
SEC2	YNL272C	Guanyl-nucleotide exchange factor for the small G-protein Sec4p	physical	1	1	1	Reconstituted Complex
FCP1	YMR277W	Carboxy-terminal domain (CTD) phosphatase	genetic	1	1	1	Negative Genetic
PFY1	YOR122C	Profilin	genetic	1	1	1	Negative Genetic
BET4	YJL031C	Alpha subunit of Type II geranylgeranyltransferase	genetic	1	1	1	Negative Genetic
RTN1	YDR233C	Reticulon protein	genetic	1	1	1	Dosage Growth Defect
BTS1	YPL069C	Geranylgeranyl diphosphate synthase (GGPPS)	genetic	1	1	1	Negative Genetic
HRQ1	YDR291W	3'-5' DNA helicase of the conserved RecQ family	genetic	1	1	1	Negative Genetic
MSS4	YDR208W	Phosphatidylinositol-4-phosphate 5-kinase	genetic	1	1	1	Dosage Rescue
ACB1	YGR037C	Acyl-CoA-binding protein	physical	1	1	1	Affinity Capture-MS
CAB4	YGR277C	Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC)	genetic	1	1	1	Negative Genetic
SEC14	YMR079W	Phosphatidylinositol/phosphatidylcholine transfer protein	genetic	1	1	1	Phenotypic Suppression
PIK1	YNL267W	Phosphatidylinositol 4-kinase	genetic	1	1	1	Synthetic Lethality
CPR4	YCR069W	Peptidyl-prolyl cis-trans isomerase (cyclophilin)	genetic	1	1	1	Negative Genetic
COS7	YDL248W	Endosomal protein involved in turnover of plasma membrane proteins	genetic	1	1	1	Negative Genetic
KRE9	YJL174W	Glycoprotein involved in cell wall beta-glucan assembly	genetic	1	1	1	Negative Genetic
KRE1	YNL322C	Cell wall glycoprotein involved in beta-glucan assembly	genetic	1	1	1	Synthetic Growth Defect
RPS21B	YJL136C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
RPS30A	YLR287C-A	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
ICT1	YLR099C	Lysophosphatidic acid acyltransferase	genetic	1	1	1	Negative Genetic
MTC4	YBR255W	Protein of unknown function	genetic	1	1	1	Negative Genetic