| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
15 |
3 |
12 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
physical |
14 |
6 |
11 |
Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex |
| ESC2 |
YDR363W |
Sumo-like domain protein |
genetic |
10 |
3 |
8 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| RMI1 |
YPL024W |
Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Lethality |
| COX5A |
YNL052W |
Subunit Va of cytochrome c oxidase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MKS1 |
YNL076W |
Pleiotropic negative transcriptional regulator |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DPB11 |
YJL090C |
DNA replication initiation protein |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SMT1 |
YJL147C |
Translational repressor of the mitochondrial ATP6/8 mRNA |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SRN2 |
YLR119W |
Component of the ESCRT-I complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HAP4 |
YKL109W |
Transcription factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| COQ10 |
YOL008W |
Coenzyme Q (ubiquinone) binding protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ROX1 |
YPR065W |
Heme-dependent repressor of hypoxic genes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PHB2 |
YGR231C |
Subunit of the prohibitin complex (Phb1p-Phb2p) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CYT2 |
YKL087C |
Cytochrome c1 heme lyase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HEM25 |
YDL119C |
Mitochondrial glycine transporter |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NSE1 |
YLR007W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PET122 |
YER153C |
Mitochondrial translational activator specific for the COX3 mRNA |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ATP10 |
YLR393W |
Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CYT1 |
YOR065W |
Cytochrome c1 |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP1 |
YDR087C |
Essential evolutionarily conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PEX19 |
YDL065C |
Chaperone and import receptor for newly-synthesized class I PMPs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE29 |
YER038C |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HAP5 |
YOR358W |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| AOS1 |
YPR180W |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| MRPL1 |
YDR116C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LAT1 |
YNL071W |
Dihydrolipoamide acetyltransferase component (E2) of the PDC |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HTA2 |
YBL003C |
Histone H2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGF29 |
YCL010C |
Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC53 |
YDL132W |
Cullin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBS2 |
YJL128C |
MAP kinase kinase of the HOG signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSI1 |
YBR195C |
Subunit of chromatin assembly factor I (CAF-1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK11 |
YKL021C |
Protein involved in an early step of 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YGL235W |
YGL235W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA13 |
YPR036W |
Subunit H of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRP102 |
YKL154W |
Signal recognition particle (SRP) receptor beta subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDL157C |
YDL157C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBI4 |
YLL039C |
Ubiquitin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPR078C |
YPR078C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUE1 |
YPR151C |
Protein required for degradation of unstable forms of cytochrome c |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS60 |
YDR486C |
Protein involved in late endosome to vacuole transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TMH11 |
YJR085C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHR2 |
YKL078W |
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FIS1 |
YIL065C |
Protein involved in mitochondrial fission and peroxisome abundance |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEX13 |
YLR191W |
Peroxisomal importomer complex component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG1 |
YOL067C |
Transcription factor (bHLH) involved in interorganelle communication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SIL1 |
YOL031C |
Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ATP18 |
YML081C-A |
Subunit of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADE16 |
YLR028C |
Enzyme of 'de novo' purine biosynthesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RPL35A |
YDL191W |
Ribosomal 60S subunit protein L35A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SLM3 |
YDL033C |
tRNA-specific 2-thiouridylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AAD4 |
YDL243C |
Putative aryl-alcohol dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM34 |
YMR003W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBP4 |
YGR174C |
Mitochondrial protein required for assembly of cytochrome bc1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP2 |
YLR239C |
Lipoyl ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCF1 |
YML030W |
Cytochrome c oxidase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAN6 |
YIL145C |
Pantothenate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP23 |
YNR020C |
Putative metalloprotease of the mitochondrial inner membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
