Standard name Systematic name Name description Description
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress
Visualize the interactome of SPC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.065 0.104 0.180
ER 0.860 0.837 0.584
Vac/Vac Memb 0.152 0.125 NaN
Cell Periphery NaN NaN 0.067
Mito NaN NaN 0.303
Nuc Periphery NaN NaN 0.079

GFP localization & abundance

GFP localization GFP abundance
ER 5550

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SPC1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 7 4 5 Dosage Rescue, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) physical 3 3 3 Co-purification, Affinity Capture-MS, PCA
ERV41 YML067C Protein localized to COPII-coated vesicles physical 3 1 3 PCA, PCA, PCA
KAR2 YJL034W ATPase involved in protein import into the ER genetic 3 2 2 Negative Genetic, Negative Genetic, Positive Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
SPC2 YML055W Subunit of signal peptidase complex physical 2 2 2 Affinity Capture-MS, PCA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 2 1 2 PCA, PCA
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 1 1 Positive Genetic, Positive Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 2 1 1 Negative Genetic, Negative Genetic
EMP65 YER140W Integral membrane protein of the ER genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ZAP1 YJL056C Zinc-regulated transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPL10 YLR075W Ribosomal 60S subunit protein L10 physical 1 1 1 Affinity Capture-MS
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Negative Genetic
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex physical 1 1 1 Affinity Capture-MS
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Positive Genetic
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
RPL23A YBL087C Ribosomal 60S subunit protein L23A physical 1 1 1 Affinity Capture-MS
RPC53 YDL150W RNA polymerase III subunit C53 genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex physical 1 1 1 PCA
SEC63 YOR254C Essential subunit of Sec63 complex physical 1 1 1 PCA
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Phenotypic Enhancement
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein physical 1 1 1 PCA
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Affinity Capture-MS
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase physical 1 1 1 PCA
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein physical 1 1 1 PCA
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 1 1 1 PCA
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
LAC1 YKL008C Ceramide synthase component physical 1 1 1 PCA
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Synthetic Growth Defect
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
SBH2 YER019C-A Ssh1p-Sss1p-Sbh2p complex component physical 1 1 1 Affinity Capture-Western
CWC15 YDR163W Non-essential protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Positive Genetic
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
AMA1 YGR225W Activator of meiotic anaphase promoting complex (APC/C) genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis physical 1 1 1 PCA
ELO3 YLR372W Elongase physical 1 1 1 PCA
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
SBH1 YER087C-B Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) physical 1 1 1 Affinity Capture-Western
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
ERV46 YAL042W Protein localized to COPII-coated vesicles physical 1 1 1 PCA
SNL1 YIL016W Ribosome-associated protein physical 1 1 1 PCA
ERG25 YGR060W C-4 methyl sterol oxidase physical 1 1 1 PCA
PEX27 YOR193W Peripheral peroxisomal membrane protein physical 1 1 1 Affinity Capture-MS
GTT1 YIR038C ER associated glutathione S-transferase physical 1 1 1 Two-hybrid
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase physical 1 1 1 PCA
ERV29 YGR284C Protein localized to COPII-coated vesicles physical 1 1 1 PCA
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Synthetic Growth Defect
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Negative Genetic
SNU13 YEL026W RNA binding protein physical 1 1 1 Affinity Capture-MS
ORM2 YLR350W Protein that mediates sphingolipid homeostasis physical 1 1 1 PCA
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I physical 1 1 1 PCA
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 Affinity Capture-MS
RPL36B YPL249C-A Ribosomal 60S subunit protein L36B physical 1 1 1 Affinity Capture-MS
ALG1 YBR110W Mannosyltransferase physical 1 1 1 PCA
CAN1 YEL063C Plasma membrane arginine permease physical 1 1 1 PCA
BAP3 YDR046C Amino acid permease physical 1 1 1 PCA
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI physical 1 1 1 PCA
CUE1 YMR264W Ubiquitin-binding protein physical 1 1 1 PCA
MRH1 YDR033W Protein that localizes primarily to the plasma membrane physical 1 1 1 Affinity Capture-MS
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 Affinity Capture-MS
IFA38 YBR159W Microsomal beta-keto-reductase physical 1 1 1 PCA
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-MS
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Negative Genetic
YAR010C YAR010C Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
TCM62 YBR044C Protein involved in assembly of the succinate dehydrogenase complex physical 1 1 1 Affinity Capture-MS
TSC13 YDL015C Enoyl reductase physical 1 1 1 Affinity Capture-MS
SPC3 YLR066W Subunit of signal peptidase complex physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
SPC2 YML055W Subunit of signal peptidase complex genetic 1 1 1 Synthetic Growth Defect
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering physical 1 1 1 Affinity Capture-MS
YNR021W YNR021W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering physical 1 1 1 Affinity Capture-MS
YRO2 YBR054W Protein with a putative role in response to acid stress physical 1 1 1 PCA
TAT1 YBR069C Amino acid transporter for valine, leucine, isoleucine, and tyrosine physical 1 1 1 PCA
YHL042W YHL042W Endoplasmic reticulum protein physical 1 1 1 PCA
SUR2 YDR297W Sphinganine C4-hydroxylase physical 1 1 1 PCA
STE24 YJR117W Highly conserved zinc metalloprotease physical 1 1 1 PCA
YET1 YKL065C Endoplasmic reticulum transmembrane protein physical 1 1 1 PCA
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit physical 1 1 1 PCA
THI73 YLR004C Putative plasma membrane permease physical 1 1 1 PCA
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
TOM71 YHR117W Mitochondrial outer membrane protein genetic 1 1 1 Positive Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Negative Genetic
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHL017W YHL017W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
ZRC1 YMR243C Vacuolar membrane zinc transporter genetic 1 1 1 Negative Genetic
URK1 YNR012W Uridine/cytidine kinase genetic 1 1 1 Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter physical 1 1 1 Affinity Capture-MS
RPP1A YDL081C Ribosomal stalk protein P1 alpha physical 1 1 1 Affinity Capture-MS
FTR1 YER145C High affinity iron permease physical 1 1 1 Affinity Capture-MS
OLE1 YGL055W Delta(9) fatty acid desaturase physical 1 1 1 Affinity Capture-MS
RPL37A YLR185W Ribosomal 60S subunit protein L37A physical 1 1 1 Affinity Capture-MS
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Negative Genetic
ATF2 YGR177C Alcohol acetyltransferase genetic 1 1 1 Positive Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ACL4 YDR161W Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ATG21 YPL100W Phosphoinositide binding protein genetic 1 1 1 Negative Genetic
LAG1 YHL003C Ceramide synthase component physical 1 1 1 PCA
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Negative Genetic
SHR3 YDL212W Endoplasmic reticulum packaging chaperone physical 1 1 1 PCA
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 1 1 1 Positive Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
PEX22 YAL055W Putative peroxisomal membrane protein genetic 1 1 1 Positive Genetic
CHO1 YER026C Phosphatidylserine synthase physical 1 1 1 PCA
AFB1 YLR040C MATalpha-specific a-factor blocker genetic 1 1 1 Negative Genetic
ELO1 YJL196C Elongase I, medium-chain acyl elongase physical 1 1 1 PCA
PMP3 YDR276C Small plasma membrane protein physical 1 1 1 PCA
GMC1 YDR506C Protein involved in meiotic progression physical 1 1 1 PCA
ERD2 YBL040C HDEL receptor physical 1 1 1 PCA
GAS4 YOL132W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
FYV12 YOR183W Protein of unknown function genetic 1 1 1 Negative Genetic