Standard name Systematic name Name description Description
STE2 YFL026W Receptor for alpha-factor pheromone Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
Visualize the interactome of STE2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1 235

CYCLoPs localization & abundance

WT1 WT2 WT3
Golgi 0.076 NaN 0.203
Mito 0.090 0.20 NaN
Nucleolus 0.097 NaN NaN
Nucleus 0.207 0.15 0.103
Vac/Vac Memb 0.621 0.50 0.655
Cort. Patches NaN 0.05 NaN
Cytoplasm NaN 0.10 0.057
ER NaN NaN 0.103

GFP localization & abundance

GFP localization GFP abundance
vacuole technical problem

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
STE2 0 0 0 1 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
STE2 YFL026W Receptor for alpha-factor pheromone physical 11 5 11 Affinity Capture-Western, FRET, Affinity Capture-Western, Reconstituted Complex, FRET, PCA, PCA, Reconstituted Complex, FRET, PCA, Co-purification
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 5 4 4 Two-hybrid, Affinity Capture-Western, Two-hybrid, PCA, FRET
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
STE4 YOR212W G protein beta subunit genetic 3 2 3 Dosage Rescue, Dosage Rescue, Dosage Growth Defect
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 3 1 3 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
MF(ALPHA)1 YPL187W Mating pheromone alpha-factor, made by alpha cells physical 3 3 2 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 2 2 2 chromatin immunoprecipitation-chip evidence, northern blot evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 2 2 2 Synthetic Rescue, Dosage Rescue
GPA1 YHR005C Subunit of G protein involved in pheromone response genetic 2 2 2 Synthetic Rescue, Dosage Rescue
STE5 YDR103W Pheromone-responsive MAPK scaffold protein genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
STE4 YOR212W G protein beta subunit physical 2 1 2 Two-hybrid, Two-hybrid
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 DNA to cDNA expression microarray evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family regulation 1 1 1 RNA-sequencing evidence
SIR3 YLR442C Silencing protein regulation 1 1 1 RNA-sequencing evidence
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains regulation 1 1 1 RNA-sequencing evidence
CDC73 YLR418C Component of the Paf1p complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUT3 YKL015W Transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPN1 YPR133C Protein involved in RNA polymerase II transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MOT1 YPL082C Essential protein involved in regulation of transcription regulation 1 1 1 northern blot evidence
MATALPHA2 YCR039C Homeobox-domain protein regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases genetic 1 1 1 Synthetic Rescue
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Co-localization
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
AXL1 YPR122W Haploid specific endoprotease of a-factor mating pheromone genetic 1 1 1 Phenotypic Enhancement
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Dosage Lethality
AFR1 YDR085C Protein required for pheromone-induced projection (shmoo) formation genetic 1 1 1 Dosage Rescue
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Affinity Capture-MS
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 Reconstituted Complex
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis genetic 1 1 1 Phenotypic Enhancement
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Dosage Lethality
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 1 1 1 Phenotypic Suppression
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex physical 1 1 1 PCA
STE3 YKL178C Receptor for a factor pheromone physical 1 1 1 Reconstituted Complex
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Phenotypic Suppression
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Synthetic Rescue
VPS28 YPL065W Component of the ESCRT-I complex genetic 1 1 1 Synthetic Rescue
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Synthetic Rescue
STE7 YDL159W Signal transducing MAP kinase kinase genetic 1 1 1 Phenotypic Suppression
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Phenotypic Suppression
MATALPHA2 YCR039C Homeobox-domain protein physical 1 1 1 Co-localization
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 Reconstituted Complex
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis genetic 1 1 1 Phenotypic Enhancement
GEF1 YJR040W Voltage-gated chloride channel genetic 1 1 1 Phenotypic Suppression
ACB1 YGR037C Acyl-CoA-binding protein physical 1 1 1 Affinity Capture-MS
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Reconstituted Complex
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
MF(ALPHA)2 YGL089C Mating pheromone alpha-factor, made by alpha cells physical 1 1 1 Co-purification
LSB6 YJL100W Type II phosphatidylinositol 4-kinase genetic 1 1 1 Phenotypic Suppression
GUP2 YPL189W Probable membrane protein physical 1 1 1 PCA
PPN2 YNL217W Zn2+-dependent endopolyphosphatase physical 1 1 1 Affinity Capture-MS
SOP4 YJL192C ER-membrane protein genetic 1 1 1 Synthetic Rescue