Standard name Systematic name Name description Description
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder
Visualize the interactome of FIG4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.528 0.571 0.789
Endosome 0.168 NaN 0.053
Mito 0.199 0.141 NaN
Vac/Vac Memb 0.168 0.333 0.106

GFP localization & abundance

GFP localization GFP abundance
ambiguous 339

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
FIG4 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_3221 (PI 3,5-P2 phosphatase (1-16:1, 2-18:1), vacuolar membrane), r_3217 (PI 3,5-P2 phosphatase (1-16:1, 2-16:1), vacuolar membrane), r_3216 (PI 3,5-P2 phosphatase (1-16:0, 2-16:1), vacuolar membrane), r_3220 (PI 3,5-P2 phosphatase (1-16:0, 2-18:1), vacuolar membrane), r_3223 (PI 3,5-P2 phosphatase (1-18:1, 2-18:1), vacuolar membrane), r_3222 (PI 3,5-P2 phosphatase (1-18:0, 2-18:1), vacuolar membrane), r_3219 (PI 3,5-P2 phosphatase (1-18:1, 2-16:1), vacuolar membrane), r_3218 (PI 3,5-P2 phosphatase (1-18:0, 2-16:1), vacuolar membrane)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
VAC14 YLR386W Enzyme regulator physical 8 4 6 Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase physical 5 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FIG2 YCR089W Cell wall adhesin, expressed specifically during mating genetic 3 2 1 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
ATG18 YFR021W Phosphoinositide binding protein genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 2 1 2 Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 2 Negative Genetic, Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Positive Genetic, Positive Genetic
FIG1 YBR040W Integral membrane protein required for efficient mating genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Negative Genetic
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
DUT1 YBR252W Deoxyuridine triphosphate diphosphatase (dUTPase) genetic 1 1 1 Positive Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
OAF1 YAL051W Oleate-activated transcription factor physical 1 1 1 Affinity Capture-MS
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis physical 1 1 1 Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
PSR1 YLL010C Plasma membrane-associated protein phosphatase genetic 1 1 1 Positive Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Negative Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Positive Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Positive Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Positive Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Positive Genetic
SYN8 YAL014C Endosomal SNARE related to mammalian syntaxin 8 genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A genetic 1 1 1 Negative Genetic
RMD1 YDL001W Cytoplasmic protein required for sporulation genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
NVJ3 YDR179W-A Protein with a potential role in tethering ER and vacuoles genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
RPL31B YLR406C Ribosomal 60S subunit protein L31B genetic 1 1 1 Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Negative Genetic
PMT3 YOR321W Protein O-mannosyltransferase genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Positive Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Positive Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
GRH1 YDR517W Acetylated cis-Golgi protein, homolog of human GRASP65 genetic 1 1 1 Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
YSC83 YHR017W Non-essential mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 1 1 1 Negative Genetic
BAP3 YDR046C Amino acid permease genetic 1 1 1 Negative Genetic
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 1 1 1 Negative Genetic
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy genetic 1 1 1 Negative Genetic
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Negative Genetic
AVT5 YBL089W Putative transporter genetic 1 1 1 Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic