Standard name Systematic name Name description Description
GPA1 YHR005C Subunit of G protein involved in pheromone response Subunit of G protein involved in pheromone response; GTP-binding alpha subunit of heterotrimeric G protein; negatively regulates mating pathway by sequestering G(beta)gamma and triggering an adaptive response; activates Vps34p at endosome; protein abundance increases in response to DNA replication stress; mutations in human homolog GNAS associated with McCune-Albright syndrome
Visualize the interactome of GPA1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2 128

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud NaN NaN 0.091
Cell Periphery NaN NaN 0.711
Cort. Patches NaN NaN 0.225
Cytoplasm NaN NaN 0.123
Mito NaN NaN 0.051

GFP localization & abundance

GFP localization GFP abundance
cell periphery 9920

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GPA1 0 0 0 5 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
STE4 YOR212W G protein beta subunit physical 20 5 18 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Co-purification, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
SST2 YLR452C GTPase-activating protein for Gpa1p physical 7 4 5 Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Affinity Capture-Western, Co-fractionation, Affinity Capture-Western
STE2 YFL026W Receptor for alpha-factor pheromone physical 5 4 4 Two-hybrid, Affinity Capture-Western, Two-hybrid, PCA, FRET
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 5 3 3 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-localization, Affinity Capture-Western
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 4 3 4 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement
STE4 YOR212W G protein beta subunit genetic 4 3 4 Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Growth Defect
FKH2 YNL068C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
STE18 YJR086W G protein gamma subunit physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, FRET
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 3 2 3 Dosage Rescue, Dosage Rescue, Phenotypic Suppression
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p physical 3 3 1 Affinity Capture-Western, Reconstituted Complex, Biochemical Activity
KAR3 YPR141C Minus-end-directed microtubule motor physical 3 2 1 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
STE2 YFL026W Receptor for alpha-factor pheromone genetic 2 2 2 Synthetic Rescue, Dosage Rescue
STE11 YLR362W Signal transducing MEK kinase genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
ELM1 YKL048C Serine/threonine protein kinase physical 2 2 1 Biochemical Activity, Affinity Capture-Western
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex physical 2 2 1 Affinity Capture-Western, Biochemical Activity
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family regulation 1 1 1 RNA-sequencing evidence
SIR3 YLR442C Silencing protein regulation 1 1 1 RNA-sequencing evidence
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains regulation 1 1 1 RNA-sequencing evidence
CDC73 YLR418C Component of the Paf1p complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 DNA to cDNA expression microarray evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUT3 YKL015W Transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) physical 1 1 1 PCA
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 1 1 1 Phenotypic Suppression
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 1 1 1 Biochemical Activity
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein physical 1 1 1 Affinity Capture-MS
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 1 1 1 Synthetic Lethality
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-Western
UBP12 YJL197W Ubiquitin-specific protease physical 1 1 1 Affinity Capture-Western
RGS2 YOR107W Negative regulator of glucose-induced cAMP signaling physical 1 1 1 Affinity Capture-Western
MDM1 YML104C PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs physical 1 1 1 Affinity Capture-Western
RAX1 YOR301W Protein involved in establishing bud site selection physical 1 1 1 Affinity Capture-Western
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Affinity Capture-Western
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism physical 1 1 1 Affinity Capture-Western
NAT4 YMR069W N alpha-acetyl-transferase physical 1 1 1 Affinity Capture-Western
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs physical 1 1 1 Affinity Capture-Western
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Phenotypic Suppression
MET30 YIL046W F-box protein containing five copies of the WD40 motif physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
SYG1 YIL047C Plasma membrane protein of unknown function genetic 1 1 1 Dosage Rescue
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
RAM1 YDL090C Beta subunit of the CAAX farnesyltransferase (FTase) genetic 1 1 1 Synthetic Rescue
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Synthetic Rescue
STE5 YDR103W Pheromone-responsive MAPK scaffold protein genetic 1 1 1 Synthetic Rescue
STE7 YDL159W Signal transducing MAP kinase kinase genetic 1 1 1 Synthetic Rescue
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 1 1 1 Synthetic Rescue
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Rescue
RPN2 YIL075C Subunit of the 26S proteasome genetic 1 1 1 Synthetic Rescue
MATALPHA1 YCR040W Transcriptional co-activator that regulates mating-type-specific genes genetic 1 1 1 Dosage Rescue
STE3 YKL178C Receptor for a factor pheromone genetic 1 1 1 Dosage Rescue
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Dosage Rescue
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Synthetic Lethality
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 1 1 1 Synthetic Lethality