Standard name Systematic name Name description Description
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication
Visualize the interactome of GYP5
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.078 0.066 NaN
Budsite 0.065 0.059 NaN
Cort. Patches 0.163 0.121 NaN
Cytoplasm 0.727 0.664 0.855
Endosome NaN 0.066 NaN
Peroxisome NaN 0.100 NaN
SpindlePole NaN 0.076 0.085

GFP localization & abundance

GFP localization GFP abundance
ambiguous, bud neck, cytoplasm, cell periphery, bud 1940

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GYP5 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 17 8 10 Affinity Capture-MS, Two-hybrid, Two-hybrid, Protein-peptide, Reconstituted Complex, Affinity Capture-Western, Far Western, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, PCA
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis physical 14 7 8 Affinity Capture-Western, Far Western, Far Western, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Co-localization, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western
RVS161 YCR009C Amphiphysin-like lipid raft protein physical 8 3 7 Two-hybrid, Two-hybrid, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
PIN3 YPR154W Negative regulator of actin nucleation-promoting factor activity physical 2 1 2 Two-hybrid, Two-hybrid
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 2 1 2 Two-hybrid, Two-hybrid
DAP2 YHR028C Dipeptidyl aminopeptidase genetic 2 1 2 Negative Genetic, Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 2 2 1 PCA, Two-hybrid
YPT1 YFL038C Rab family GTPase genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
TUP1 YCR084C General repressor of transcription in complex with Cyc8p physical 2 1 1 Two-hybrid, Two-hybrid
SNX41 YDR425W Sorting nexin physical 2 1 1 Two-hybrid, Two-hybrid
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p physical 2 1 1 Two-hybrid, Two-hybrid
STB2 YMR053C Protein that interacts with Sin3p in a two-hybrid assay physical 2 1 1 Two-hybrid, Two-hybrid
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 2 1 1 Two-hybrid, Two-hybrid
ARR1 YPR199C Transcriptional activator of the basic leucine zipper (bZIP) family physical 2 1 1 Two-hybrid, Two-hybrid
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 1 1 1 Two-hybrid
GLY1 YEL046C Threonine aldolase physical 1 1 1 Affinity Capture-Western
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
DIA4 YHR011W Probable mitochondrial seryl-tRNA synthetase physical 1 1 1 Two-hybrid
GSP2 YOR185C GTP binding protein (mammalian Ranp homolog) genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Synthetic Lethality
LSM2 YBL026W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 1 1 1 Two-hybrid
YSC84 YHR016C Actin-binding protein physical 1 1 1 Two-hybrid
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Dosage Lethality
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 1 1 1 Affinity Capture-MS
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Two-hybrid
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways physical 1 1 1 Two-hybrid
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation physical 1 1 1 Two-hybrid
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Two-hybrid
STE50 YCL032W Adaptor protein for various signaling pathways physical 1 1 1 Two-hybrid
NUM1 YDR150W Protein required for nuclear migration physical 1 1 1 Two-hybrid
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex physical 1 1 1 Two-hybrid
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Two-hybrid
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) physical 1 1 1 Two-hybrid
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Two-hybrid
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs physical 1 1 1 Two-hybrid
YGR130C YGR130C Component of the eisosome with unknown function physical 1 1 1 Two-hybrid
MYO1 YHR023W Type II myosin heavy chain physical 1 1 1 Two-hybrid
KAR2 YJL034W ATPase involved in protein import into the ER physical 1 1 1 Two-hybrid
SMY1 YKL079W Kinesin-like myosin passenger-protein physical 1 1 1 Two-hybrid
IMH1 YLR309C Protein involved in vesicular transport physical 1 1 1 Two-hybrid
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor physical 1 1 1 Two-hybrid
SPO21 YOL091W Component of the meiotic outer plaque of the spindle pole body physical 1 1 1 Two-hybrid
PLP2 YOR281C Protein that interacts with the CCT complex to stimulate actin folding physical 1 1 1 Two-hybrid
NIP100 YPL174C Large subunit of the dynactin complex physical 1 1 1 Two-hybrid
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Two-hybrid
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex physical 1 1 1 Two-hybrid
SPC25 YER018C Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
PFD1 YJL179W Subunit of heterohexameric prefoldin physical 1 1 1 Two-hybrid
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Two-hybrid
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family physical 1 1 1 Two-hybrid
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members physical 1 1 1 Two-hybrid
KAR3 YPR141C Minus-end-directed microtubule motor physical 1 1 1 Two-hybrid
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 Two-hybrid
SKN7 YHR206W Nuclear response regulator and transcription factor physical 1 1 1 Two-hybrid
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Affinity Capture-MS
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Synthetic Lethality
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Synthetic Lethality
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Positive Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Positive Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Positive Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Positive Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Positive Genetic
SED1 YDR077W Major stress-induced structural GPI-cell wall glycoprotein genetic 1 1 1 Positive Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Positive Genetic
AIM7 YDR063W Protein that interacts with Arp2/3 complex genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Phenotypic Enhancement
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis genetic 1 1 1 Synthetic Lethality
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Two-hybrid
GEF1 YJR040W Voltage-gated chloride channel genetic 1 1 1 Negative Genetic
EFG1 YGR271C-A Ribosome biogenesis factor required for maturation of 18S rRNA physical 1 1 1 Affinity Capture-MS
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Negative Genetic