Standard name Systematic name Name description Description
PIM1 YBL022C ATP-dependent Lon protease ATP-dependent Lon protease; involved in degradation of misfolded mitochondrial proteins; required for mitochondrial maintenance and biogenesis; regulates mitochondrial DNA copy number with Mrx6p; subunit of a complex containing Mrx6p, Pet20p, and Mam33p that may regulate mtDNA replication; protease-independent, chaperone-like function in mitochondrial membrane complex assembly; localizes to the mitochondrial matrix
Visualize the interactome of PIM1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.098 NaN 0.070
Mito 0.754 0.812 0.696
Nucleolus 0.112 0.074 0.055
Peroxisome 0.134 0.140 0.345
Vac/Vac Memb 0.116 0.085 NaN
SpindlePole NaN NaN 0.081

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 14500

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PIM1 4 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
MRX6 YNL295W Mitochondrial ribosome-associated protein physical 3 3 1 Affinity Capture-Western, Affinity Capture-MS, Co-localization
CRD1 YDL142C Cardiolipin synthase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 2 1 2 Dosage Rescue, Dosage Rescue
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LEU3 YLR451W Zinc-knuckle transcription factor, repressor and activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
NPL6 YMR091C Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Synthetic Growth Defect
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
MIS1 YBR084W Mitochondrial C1-tetrahydrofolate synthase physical 1 1 1 Affinity Capture-MS
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
SAM1 YLR180W S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase physical 1 1 1 Affinity Capture-MS
SNP1 YIL061C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
RSC6 YCR052W Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-MS
PIM1 YBL022C ATP-dependent Lon protease physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c physical 1 1 1 Affinity Capture-MS
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
RPM2 YML091C Protein subunit of mitochondrial RNase P physical 1 1 1 Proximity Label-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Dosage Rescue
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Dosage Rescue
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Synthetic Lethality
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
UPS2 YLR168C Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Positive Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
RSB1 YOR049C Sphingoid long-chain base (LCB) efflux transporter genetic 1 1 1 Negative Genetic
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
YLH47 YPR125W Mitochondrial inner membrane protein genetic 1 1 1 Positive Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Negative Genetic
YSC83 YHR017W Non-essential mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Positive Genetic
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
HSP104 YLL026W Disaggregase genetic 1 1 1 Phenotypic Suppression
MAE1 YKL029C Mitochondrial malic enzyme genetic 1 1 1 Positive Genetic
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
FUM1 YPL262W Fumarase genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex genetic 1 1 1 Negative Genetic
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Affinity Capture-MS
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-Western
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO3 YLR372W Elongase genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) physical 1 1 1 Affinity Capture-Western
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Synthetic Growth Defect
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
ERG5 YMR015C C-22 sterol desaturase genetic 1 1 1 Negative Genetic
AGP2 YBR132C Plasma membrane regulator of polyamine and carnitine transport genetic 1 1 1 Negative Genetic
INA17 YPL099C F1F0 ATPase synthase peripheral stalk assembly factor genetic 1 1 1 Negative Genetic
MRS2 YOR334W Mitochondrial inner membrane Mg(2+) channel genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) physical 1 1 1 Affinity Capture-Western
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Synthetic Growth Defect
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 1 1 1 Positive Genetic
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Positive Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Positive Genetic
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
FMP30 YPL103C Protein with a role in maintaining mitochondrial morphology genetic 1 1 1 Positive Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Positive Genetic
OMA1 YKR087C Metalloendopeptidase of the mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 1 1 1 Positive Genetic
PET20 YPL159C Mitochondrial protein physical 1 1 1 Affinity Capture-MS