Standard name Systematic name Name description Description
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
Visualize the interactome of SIR1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 69

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SIR1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ORC1 YML065W Largest subunit of the origin recognition complex physical 14 5 7 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Co-crystal Structure, Affinity Capture-Western, Co-crystal Structure, Two-hybrid, Affinity Capture-Western, Co-fractionation
SIR3 YLR442C Silencing protein genetic 9 4 9 Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 7 3 6 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 7 2 6 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid
SIR3 YLR442C Silencing protein physical 6 4 5 Affinity Capture-MS, Co-localization, Co-localization, Two-hybrid, Two-hybrid, Reconstituted Complex
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 6 3 3 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 4 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
FKH1 YIL131C Forkhead family transcription factor genetic 4 2 4 Dosage Rescue, Phenotypic Suppression, Dosage Rescue, Phenotypic Suppression
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) physical 4 3 1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 3 2 3 Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 3 2 3 Co-localization, Affinity Capture-MS, Co-localization
HHF1 YBR009C Histone H4 genetic 2 2 2 Dosage Rescue, Phenotypic Enhancement
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 2 2 Phenotypic Enhancement, Dosage Rescue
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 2 2 Negative Genetic, Synthetic Rescue
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 2 2 Synthetic Rescue, Dosage Rescue
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
FUS1 YCL027W Membrane protein localized to the shmoo tip physical 2 1 2 Two-hybrid, Two-hybrid
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Negative Genetic, Positive Genetic
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 2 2 1 Synthetic Lethality, Phenotypic Enhancement
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 1 Negative Genetic, Positive Genetic
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Dosage Rescue, Dosage Rescue
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Dosage Rescue
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 genetic 1 1 1 Phenotypic Enhancement
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Dosage Rescue
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) physical 1 1 1 Affinity Capture-Western
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA genetic 1 1 1 Phenotypic Suppression
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Phenotypic Enhancement
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Rescue
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Synthetic Growth Defect
HHT1 YBR010W Histone H3 genetic 1 1 1 Phenotypic Enhancement
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Rescue
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Lethality
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Rescue
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Synthetic Rescue
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Rescue
YCL021W-A YCL021W-A Putative protein of unknown function physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSF2 YDR312W Protein required for ribosomal large subunit maturation genetic 1 1 1 Dosage Rescue
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 1 1 1 Dosage Rescue
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Synthetic Rescue
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Synthetic Rescue
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Rescue
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
TIM13 YGR181W Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Phenotypic Enhancement
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Phenotypic Enhancement
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Positive Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Positive Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Phenotypic Enhancement
ORC3 YLL004W Subunit of the origin recognition complex (ORC) physical 1 1 1 Affinity Capture-Western
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci physical 1 1 1 Co-localization
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Dosage Rescue
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Phenotypic Enhancement
HHT2 YNL031C Histone H3 genetic 1 1 1 Phenotypic Enhancement
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Phenotypic Enhancement
HST2 YPL015C Cytoplasmic NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Growth Defect
SHY1 YGR112W Mitochondrial inner membrane protein required for complex IV assembly physical 1 1 1 Affinity Capture-MS