Standard name Systematic name Name description Description
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p Cytochrome b reductase and NADH-dependent reductase for Dph3p; required for diphthamide synthesis and tRNA wobble uridine modification; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
Visualize the interactome of CBR1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.141 0.133 0.094
ER 0.750 0.852 0.869
Mito 0.096 NaN NaN
Vac/Vac Memb 0.064 NaN NaN
Cell Periphery NaN NaN 0.062
Cort. Patches NaN NaN 0.062

GFP localization & abundance

GFP localization GFP abundance
ER 4820

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CBR1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4196 (NADH:ferricytochrome-b5 oxidoreductase), r_4197 (NADH-cytochrome b5 reductase 1 (EC 1.6.2.2) (Microsomal cytochrome b reductase) (P35))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
GET2 YER083C Subunit of the GET complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 2 1 2 Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 2 1 2 Negative Genetic, Negative Genetic
ATS1 YAL020C Protein required for modification of wobble nucleosides in tRNA genetic 2 1 2 Negative Genetic, Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 2 1 2 Negative Genetic, Negative Genetic
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 2 2 1 PCA, Affinity Capture-Western
NCP1 YHR042W NADP-cytochrome P450 reductase genetic 2 2 1 Synthetic Lethality, Phenotypic Enhancement
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 2 1 1 Negative Genetic, Negative Genetic
APM3 YBR288C Mu3-like subunit of the clathrin associated protein complex (AP-3) genetic 2 1 1 Positive Genetic, Positive Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
MTC4 YBR255W Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
NCW1 YMR122W-A Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
PRY1 YJL079C Lipid binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 2 1 1 Positive Genetic, Positive Genetic
YMD8 YML038C Putative nucleotide sugar transporter genetic 2 1 1 Positive Genetic, Positive Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 2 1 1 Positive Genetic, Positive Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 2 1 1 Positive Genetic, Positive Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 2 1 1 Positive Genetic, Positive Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 2 1 1 Positive Genetic, Positive Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 DNA to cDNA expression microarray evidence
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
BDH2 YAL061W Putative medium-chain alcohol dehydrogenase with similarity to BDH1 genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
ARP10 YDR106W Component of the dynactin complex genetic 1 1 1 Negative Genetic
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
YAR010C YAR010C Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-MS
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase physical 1 1 1 Affinity Capture-MS
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B physical 1 1 1 Affinity Capture-MS
RPL10 YLR075W Ribosomal 60S subunit protein L10 physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 1 1 1 Affinity Capture-MS
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering physical 1 1 1 Affinity Capture-MS
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-MS
TOP1 YOL006C Topoisomerase I physical 1 1 1 Affinity Capture-MS
RPL36B YPL249C-A Ribosomal 60S subunit protein L36B physical 1 1 1 Affinity Capture-MS
YDR124W YDR124W Mitochondrial protein of unknown function physical 1 1 1 Affinity Capture-MS
YLF2 YHL014C Protein of unknown function physical 1 1 1 Affinity Capture-MS
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
ORM2 YLR350W Protein that mediates sphingolipid homeostasis physical 1 1 1 PCA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
ERG6 YML008C Delta(24)-sterol C-methyltransferase physical 1 1 1 PCA
PLN1 YKR046C Perilipin, involved in formation and stability of lipid droplets physical 1 1 1 PCA
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter physical 1 1 1 PCA
YOL075C YOL075C Putative ABC transporter physical 1 1 1 PCA
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
KTI11 YBL071W-A Zn-ribbon protein that co-purifies with Dph1 and Dph2 physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RTN1 YDR233C Reticulon protein physical 1 1 1 Affinity Capture-MS
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Lethality
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A genetic 1 1 1 Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
MSS2 YDL107W Peripherally bound inner membrane protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
YGR130C YGR130C Component of the eisosome with unknown function genetic 1 1 1 Negative Genetic
VPS62 YGR141W Vacuolar protein sorting (VPS) protein genetic 1 1 1 Negative Genetic
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
VHC1 YBR235W Vacuolar membrane cation-chloride cotransporter (CCC) genetic 1 1 1 Negative Genetic
YPT10 YBR264C Rab family GTP-binding protein genetic 1 1 1 Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 1 1 1 Negative Genetic
GFD2 YCL036W Protein of unknown function genetic 1 1 1 Negative Genetic
TMA17 YDL110C Regulatory gamma subunit of fatty acid synthase (FAS) genetic 1 1 1 Negative Genetic
SNQ2 YDR011W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
TRK2 YKR050W Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Negative Genetic
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Negative Genetic
PBA1 YLR199C Protein involved in 20S proteasome assembly genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
FYV12 YOR183W Protein of unknown function genetic 1 1 1 Negative Genetic
SDD4 YPR022C Putative transcription factor, as suggested by computational analysis genetic 1 1 1 Negative Genetic
MDM36 YPR083W Mitochondrial protein genetic 1 1 1 Negative Genetic
YLR162W YLR162W Protein of unknown function genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
CRT10 YOL063C Protein required for the degradation of mutant 25S rRNAs genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Phenotypic Enhancement
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
POL4 YCR014C DNA polymerase IV genetic 1 1 1 Positive Genetic
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Negative Genetic