Standard name Systematic name Name description Description
SYP1 YCR030C Negative regulator of WASP-Arp23 complex Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembly in vitro; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
Visualize the interactome of SYP1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.121 0.197 0.168
Budneck 0.058 0.059 0.055
Budsite 0.226 0.230 0.152
Cell Periphery 0.147 0.191 0.188
Cort. Patches 0.489 0.500 0.637
Cytoplasm 0.100 NaN 0.062
Mito 0.400 0.303 0.152
Peroxisome 0.284 0.217 0.082
Nucleus NaN NaN 0.094
SpindlePole NaN NaN 0.051

GFP localization & abundance

GFP localization GFP abundance
bud neck, cell periphery, punctate composite 4280

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SYP1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites physical 10 5 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-localization, Affinity Capture-Western, Affinity Capture-MS
SLA1 YBL007C Cytoskeletal protein binding protein physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS
MID2 YLR332W O-glycosylated plasma membrane protein physical 3 2 3 PCA, Reconstituted Complex, Reconstituted Complex
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 2 2 2 PCA, Affinity Capture-Western
LAS17 YOR181W Actin assembly factor physical 2 2 2 PCA, Affinity Capture-MS
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 2 2 2 PCA, Two-hybrid
PKC1 YBL105C Protein serine/threonine kinase physical 2 2 2 Affinity Capture-MS, Biochemical Activity
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 2 2 2 PCA, Co-crystal Structure
MRPL9 YGR220C Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase physical 2 1 2 PCA, PCA
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 2 1 2 Negative Genetic, Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 2 2 1 Synthetic Lethality, Dosage Rescue
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing genetic 1 1 1 Positive Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-MS
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Dosage Rescue
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
CDC10 YCR002C Component of the septin ring, required for cytokinesis physical 1 1 1 Affinity Capture-Western
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Dosage Lethality
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 1 1 1 Affinity Capture-Western
BNI1 YNL271C Formin physical 1 1 1 Reconstituted Complex
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Phenotypic Suppression
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 1 1 1 Negative Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic physical 1 1 1 PCA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Rescue
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p physical 1 1 1 Affinity Capture-MS
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Rescue
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein physical 1 1 1 PCA
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Proximity Label-MS
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Phenotypic Enhancement
SHS1 YDL225W Component of the septin ring that is required for cytokinesis physical 1 1 1 PCA
FPK1 YNR047W Ser/Thr protein kinase physical 1 1 1 Affinity Capture-MS
CLB2 YPR119W B-type cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-MS
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Negative Genetic
PRM9 YAR031W Pheromone-regulated protein physical 1 1 1 Two-hybrid
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
ATG8 YBL078C Ub-like protein physical 1 1 1 Affinity Capture-MS
MYO5 YMR109W One of two type I myosin motors physical 1 1 1 PCA
PRK1 YIL095W Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
SNC1 YAL030W Vesicle membrane receptor protein (v-SNARE) physical 1 1 1 Reconstituted Complex
SFK1 YKL051W Protein that regulates phospholipid asymmetry at plasma membrane physical 1 1 1 PCA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Rescue
PFY1 YOR122C Profilin genetic 1 1 1 Dosage Rescue
ENT2 YLR206W Epsin-like protein required for endocytosis and actin patch assembly physical 1 1 1 PCA
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) physical 1 1 1 Affinity Capture-MS
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway physical 1 1 1 PCA
YAP1802 YGR241C Protein of the AP180 family, involved in clathrin cage assembly physical 1 1 1 PCA
YGR130C YGR130C Component of the eisosome with unknown function physical 1 1 1 PCA
VRP1 YLR337C Verprolin, proline-rich actin-associated protein physical 1 1 1 PCA
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
YSC84 YHR016C Actin-binding protein physical 1 1 1 Two-hybrid
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Dosage Rescue
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YOR186W YOR186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
HNM1 YGL077C Plasma membrane transporter for choline, ethanolamine, and carnitine physical 1 1 1 PCA
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
DNF1 YER166W Aminophospholipid translocase (flippase) physical 1 1 1 PCA
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
GEP5 YLR091W Protein of unknown function genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor genetic 1 1 1 Dosage Rescue
FLC1 YPL221W Flavin adenine dinucleotide transporter physical 1 1 1 PCA
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
GYP8 YFL027C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Negative Genetic
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Positive Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 1 1 1 Negative Genetic