Standard name Systematic name Name description Description
LAC1 YKL008C Ceramide synthase component Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication
Visualize the interactome of LAC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1 234

CYCLoPs localization & abundance

WT1 WT2 WT3
ER 0.656 0.706 0.483
Golgi 0.052 NaN NaN
Nuc Periphery 0.167 0.088 0.223
Vac/Vac Memb 0.240 0.186 0.384
Cytoplasm NaN 0.078 0.064
Mito NaN NaN 0.090

GFP localization & abundance

GFP localization GFP abundance
ER 2840

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
LAC1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0263 (ceramide-1 synthase (24C)), r_0264 (ceramide-1 synthase (26C)), r_0265 (ceramide-2 synthase (24C)), r_0266 (ceramide-2 synthase (26C))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
LAG1 YHL003C Ceramide synthase component genetic 15 4 13 Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
LAG1 YHL003C Ceramide synthase component physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, PCA, PCA
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 5 3 3 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect
LIP1 YMR298W Ceramide synthase subunit physical 5 3 2 Two-hybrid, Two-hybrid, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
YPC1 YBR183W Alkaline ceramidase genetic 4 4 3 Dosage Rescue, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
ELO3 YLR372W Elongase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 3 3 2 beta-galactosidase reporter gene assay evidence, chromatin immunoprecipitation-chip evidence, electrophoretic mobility shift assay evidence
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism genetic 3 3 2 Dosage Rescue, Phenotypic Enhancement, Synthetic Lethality
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 2 1 2 PCA, PCA
LAC1 YKL008C Ceramide synthase component physical 2 1 2 PCA, PCA
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 2 1 1 Negative Genetic, Negative Genetic
YET1 YKL065C Endoplasmic reticulum transmembrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 1 Positive Genetic, Positive Genetic
HCM1 YCR065W Forkhead transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHA4 YLR098C DNA binding transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ROX1 YPR065W Heme-dependent repressor of hypoxic genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
CYR1 YJL005W Adenylate cyclase genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
FET3 YMR058W Ferro-O2-oxidoreductase physical 1 1 1 PCA
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
ELC1 YPL046C Elongin C, conserved among eukaryotes genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Two-hybrid
PTK2 YJR059W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Biochemical Activity
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
PKP2 YGL059W Mitochondrial protein kinase physical 1 1 1 Biochemical Activity
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 PCA
YDR541C YDR541C Aldehyde reductase physical 1 1 1 PCA
SSH1 YBR283C Subunit of the Ssh1 translocon complex physical 1 1 1 PCA
TSC13 YDL015C Enoyl reductase physical 1 1 1 PCA
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease physical 1 1 1 PCA
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein physical 1 1 1 PCA
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) physical 1 1 1 PCA
SNL1 YIL016W Ribosome-associated protein physical 1 1 1 PCA
YET1 YKL065C Endoplasmic reticulum transmembrane protein physical 1 1 1 PCA
TAH18 YPR048W Conserved NAPDH-dependent diflavin reductase physical 1 1 1 PCA
TPO5 YKL174C Protein involved in excretion of putrescine and spermidine physical 1 1 1 PCA
YPL264C YPL264C Endoplasmic reticulum protein of unknown function physical 1 1 1 PCA
ORM1 YGR038W Protein that mediates sphingolipid homeostasis physical 1 1 1 Affinity Capture-Western
ORM2 YLR350W Protein that mediates sphingolipid homeostasis physical 1 1 1 Affinity Capture-Western
YPK1 YKL126W S/T protein kinase physical 1 1 1 Biochemical Activity
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Dosage Growth Defect
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase genetic 1 1 1 Synthetic Rescue
RBK1 YCR036W Ribokinase, phosphorylates ribose to ribose-5-phosphate genetic 1 1 1 Positive Genetic
PLB2 YMR006C Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
LCB3 YJL134W Long-chain base-1-phosphate phosphatase genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Dosage Growth Defect
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Positive Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Positive Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
YCL001W-B YCL001W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
PPX1 YHR201C Exopolyphosphatase genetic 1 1 1 Negative Genetic
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
SNO1 YMR095C Protein of unconfirmed function genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Negative Genetic
YPT11 YNL304W Rab GTPase genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
YPL191C YPL191C K48-specific deubiquitinating (DUB) enzyme genetic 1 1 1 Negative Genetic
UFO1 YML088W F-box receptor protein genetic 1 1 1 Negative Genetic
UBX3 YDL091C Clathrin-coated vesicle component, regulator of endocytosis genetic 1 1 1 Negative Genetic
YML108W YML108W Protein of unknown function genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
COX18 YGR062C Protein required for membrane insertion of C-terminus of Cox2p genetic 1 1 1 Negative Genetic
ELO3 YLR372W Elongase physical 1 1 1 PCA
ERG25 YGR060W C-4 methyl sterol oxidase physical 1 1 1 PCA
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Negative Genetic
GTT1 YIR038C ER associated glutathione S-transferase physical 1 1 1 Two-hybrid
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase physical 1 1 1 PCA
BSD2 YBR290W Heavy metal ion homeostasis protein physical 1 1 1 PCA
AVT6 YER119C Vacuolar aspartate and glutamate exporter genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI physical 1 1 1 PCA
IFA38 YBR159W Microsomal beta-keto-reductase physical 1 1 1 PCA
GPI17 YDR434W Transmembrane protein physical 1 1 1 PCA
AVT3 YKL146W Vacuolar transporter physical 1 1 1 PCA
GAS3 YMR215W Putative 1,3-beta-glucanosyltransferase physical 1 1 1 PCA
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
COS8 YHL048W Endosomal protein involved in turnover of plasma membrane proteins physical 1 1 1 PCA
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease physical 1 1 1 PCA
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex physical 1 1 1 PCA