RAD16 |
YBR114W |
Nucleotide excision repair (NER) protein |
physical |
14 |
6 |
8 |
Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Co-fractionation, Affinity Capture-Western, Co-purification, Co-purification, Reconstituted Complex |
RAD26 |
YJR035W |
Protein involved in transcription-coupled nucleotide excision repair |
genetic |
10 |
2 |
10 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
ELC1 |
YPL046C |
Elongin C, conserved among eukaryotes |
physical |
10 |
5 |
6 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex |
RPB9 |
YGL070C |
RNA polymerase II subunit B12.6 |
genetic |
5 |
3 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality |
RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
physical |
4 |
3 |
3 |
Two-hybrid, Two-hybrid, Affinity Capture-Western, Biochemical Activity |
SIR3 |
YLR442C |
Silencing protein |
physical |
4 |
2 |
3 |
Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Negative Genetic, Synthetic Lethality |
SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
3 |
3 |
3 |
Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue |
DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement |
CUL3 |
YGR003W |
Ubiquitin-protein ligase |
physical |
3 |
3 |
2 |
Affinity Capture-Western, Co-purification, Reconstituted Complex |
BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
3 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
SPT5 |
YML010W |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
1 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
EUG1 |
YDR518W |
Protein disulfide isomerase of the endoplasmic reticulum lumen |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PAF1 |
YBR279W |
Component of the Paf1p complex involved in transcription elongation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Negative Genetic |
HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HRP1 |
YOL123W |
Subunit of cleavage factor I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
GAL11 |
YOL051W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MRPL10 |
YNL284C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
CMR1 |
YDL156W |
Nuclear protein with role in transcription, protein quality control |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
HTA2 |
YBL003C |
Histone H2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BUR2 |
YLR226W |
Cyclin for the Sgv1p (Bur1p) protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
OYE2 |
YHR179W |
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAC11 |
YDR488C |
Dynein intermediate chain, microtubule motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NTG1 |
YAL015C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
KIN28 |
YDL108W |
Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
UBI4 |
YLL039C |
Ubiquitin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
THO2 |
YNL139C |
Subunit of the THO complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SPT20 |
YOL148C |
Subunit of the SAGA transcriptional regulatory complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SUB2 |
YDL084W |
Component of the TREX complex required for nuclear mRNA export |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
THP1 |
YOL072W |
Nuclear pore-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SRB4 |
YER022W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RNA14 |
YMR061W |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RNA15 |
YGL044C |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
YCR090C |
YCR090C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Positive Genetic |
SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
TAO3 |
YIL129C |
Component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRP102 |
YKL154W |
Signal recognition particle (SRP) receptor beta subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMD2 |
YLR275W |
Core Sm protein Sm D2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS8 |
YAL002W |
Membrane-binding component of the CORVET complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL13A |
YDL082W |
Ribosomal 60S subunit protein L13A |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSM24 |
YDR175C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
YHR050W-A |
YHR050W-A |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSO55 |
YLR281C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBP7 |
YIL156W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
NFI1 |
YOR156C |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
NOT5 |
YPR072W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
MOT2 |
YER068W |
Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ABF1 |
YKL112W |
DNA binding protein with possible chromatin-reorganizing activity |
physical |
1 |
1 |
1 |
Co-fractionation |
MGA1 |
YGR249W |
Protein similar to heat shock transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
DID2 |
YKR035W-A |
Class E protein of the vacuolar protein-sorting (Vps) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATP14 |
YLR295C |
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GID11 |
YLR149C |
Substrate receptor of the glucose-induced degradation-deficient (GID) |
genetic |
1 |
1 |
1 |
Negative Genetic |
COQ11 |
YLR290C |
Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
AGE2 |
YIL044C |
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector |
genetic |
1 |
1 |
1 |
Negative Genetic |
NTG2 |
YOL043C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
NNT1 |
YLR285W |
S-adenosylmethionine-dependent methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |