| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
physical |
10 |
5 |
10 |
Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Two-hybrid, Co-crystal Structure, Co-crystal Structure |
| REV1 |
YOR346W |
Deoxycytidyl transferase |
physical |
9 |
3 |
5 |
Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
6 |
2 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
physical |
4 |
3 |
4 |
Reconstituted Complex, Affinity Capture-Western, Co-crystal Structure, Co-crystal Structure |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
physical |
4 |
4 |
1 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Co-localization |
| MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
physical |
4 |
3 |
1 |
Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex |
| MMS2 |
YGL087C |
Ubiquitin-conjugating enzyme variant |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Lethality, Negative Genetic |
| POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
physical |
3 |
2 |
3 |
Co-purification, Co-crystal Structure, Co-crystal Structure |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
3 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
physical |
3 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity |
| SWI6 |
YLR182W |
Transcription cofactor |
genetic |
2 |
2 |
2 |
Dosage Rescue, Negative Genetic |
| UBC13 |
YDR092W |
E2 ubiquitin-conjugating enzyme |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
physical |
1 |
1 |
1 |
Two-hybrid |
| CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| LIA1 |
YJR070C |
Deoxyhypusine hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RAD24 |
YER173W |
Checkpoint protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MSN5 |
YDR335W |
Karyopherin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| REC114 |
YMR133W |
Protein involved in early stages of meiotic recombination |
physical |
1 |
1 |
1 |
Two-hybrid |
| ADY4 |
YLR227C |
Structural component of the meiotic outer plaque |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIP1 |
YOR330C |
Mitochondrial DNA polymerase gamma |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| REV1 |
YOR346W |
Deoxycytidyl transferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SMD3 |
YLR147C |
Core Sm protein Sm D3 |
physical |
1 |
1 |
1 |
Two-hybrid |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| REV7 |
YIL139C |
Accessory subunit of DNA polymerase zeta |
physical |
1 |
1 |
1 |
Co-crystal Structure |
| SPN1 |
YPR133C |
Protein involved in RNA polymerase II transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC31 |
YNL151C |
RNA polymerase III subunit C31 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRB8 |
YCR081W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA43 |
YOR340C |
RNA polymerase I subunit A43 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| TPO5 |
YKL174C |
Protein involved in excretion of putrescine and spermidine |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNH1 |
YMR234W |
Ribonuclease H1 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT3 |
YDR394W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RGT2 |
YDL138W |
Plasma membrane high glucose sensor that regulates glucose transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR016W |
YGR016W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC66 |
YBR171W |
Non-essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCL002C |
YCL002C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL13A |
YDL082W |
Ribosomal 60S subunit protein L13A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR079W |
YGR079W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YOR1 |
YGR281W |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL17B |
YJL177W |
Ribosomal 60S subunit protein L17B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GID11 |
YLR149C |
Substrate receptor of the glucose-induced degradation-deficient (GID) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD30 |
YDR419W |
DNA polymerase eta |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RAD30 |
YDR419W |
DNA polymerase eta |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| AQY3 |
YFL054C |
Putative channel-like protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSH1 |
YBR161W |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
physical |
1 |
1 |
1 |
Two-hybrid |
| PDR3 |
YBL005W |
Transcriptional activator of the pleiotropic drug resistance network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FRM2 |
YCL026C-A |
Type II nitroreductase, using NADH as reductant |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COX7 |
YMR256C |
Subunit VII of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GUP2 |
YPL189W |
Probable membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |