| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
physical |
12 |
4 |
11 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS |
| DIS3 |
YOL021C |
Exosome core complex catalytic subunit |
physical |
12 |
3 |
10 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western |
| RRP46 |
YGR095C |
Exosome non-catalytic core component |
physical |
10 |
3 |
9 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Co-purification |
| CSL4 |
YNL232W |
Exosome non-catalytic core component |
physical |
10 |
2 |
7 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| SKI6 |
YGR195W |
Exosome non-catalytic core component |
physical |
8 |
2 |
6 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western |
| MTR3 |
YGR158C |
Exosome non-catalytic core component |
physical |
8 |
3 |
5 |
Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western |
| SKI7 |
YOR076C |
GTP-binding protein that couples the Ski complex and exosome |
physical |
6 |
3 |
6 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western |
| RRP45 |
YDR280W |
Exosome non-catalytic core component |
physical |
6 |
1 |
5 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| RRP4 |
YHR069C |
Exosome non-catalytic core component |
physical |
5 |
1 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| RRP43 |
YCR035C |
Exosome non-catalytic core component |
physical |
4 |
1 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| MPP6 |
YNR024W |
Nuclear exosome-associated RNA binding protein |
physical |
4 |
3 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex |
| RRP40 |
YOL142W |
Exosome non-catalytic core component |
physical |
3 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Positive Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ECM16 |
YMR128W |
Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MTR4 |
YJL050W |
RNA duplex-sensing translocase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| DIS3 |
YOL021C |
Exosome core complex catalytic subunit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RRP45 |
YDR280W |
Exosome non-catalytic core component |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SKI6 |
YGR195W |
Exosome non-catalytic core component |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SEC18 |
YBR080C |
AAA ATPase and SNARE disassembly chaperone |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SED5 |
YLR026C |
cis-Golgi t-SNARE syntaxin |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| UTP13 |
YLR222C |
Nucleolar protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RRP8 |
YDR083W |
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SIS2 |
YKR072C |
Negative regulatory subunit of protein phosphatase 1 (Ppz1p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CFT2 |
YLR115W |
Subunit of the mRNA cleavage and polyadenlylation factor (CPF) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CEG1 |
YGL130W |
Guanylyltransferase involved in mRNA 5' capping |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ENP1 |
YBR247C |
Protein associated with U3 and U14 snoRNAs |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NUP145 |
YGL092W |
Essential protein with distinct roles in two nuclear pore subcomplexes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| DIM1 |
YPL266W |
Essential 18S rRNA dimethylase (dimethyladenosine transferase) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC27 |
YBL084C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MIF2 |
YKL089W |
Centromeric CDEIII region binding protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MPP6 |
YNR024W |
Nuclear exosome-associated RNA binding protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MUB1 |
YMR100W |
MYND domain-containing protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| FHL1 |
YPR104C |
Regulator of ribosomal protein (RP) transcription |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HAS1 |
YMR290C |
ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOG1 |
YPL093W |
Putative GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL27A |
YHR010W |
Ribosomal 60S subunit protein L27A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP3 |
YNL282W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
physical |
1 |
1 |
1 |
PCA |
| AIR2 |
YDL175C |
RNA-binding subunit of the TRAMP nuclear RNA surveillance complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSL4 |
YNL232W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP4 |
YHR069C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRP1 |
YNL189W |
Karyopherin alpha homolog |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SKI3 |
YPR189W |
Ski complex component and TPR protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| UTP20 |
YBL004W |
Component of the small-subunit (SSU) processome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RRP42 |
YDL111C |
Exosome non-catalytic core component |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| WHI3 |
YNL197C |
RNA binding protein that modulates mRNA stability |
physical |
1 |
1 |
1 |
Protein-RNA |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
| UTP10 |
YJL109C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| UTP14 |
YML093W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| WHI4 |
YDL224C |
Putative RNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRM8 |
YDL201W |
Catalytic subunit of a tRNA methyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX9 |
YGR081C |
Protein required for pre-rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUR1 |
YPL057C |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TAF9 |
YMR236W |
Subunit (17 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SMX3 |
YPR182W |
Core Sm protein Sm F |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TRF5 |
YNL299W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSC3 |
YBR058C-A |
Protein that stimulates the activity of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC19 |
YDR201W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC26 |
YDR238C |
Essential beta-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UFD1 |
YGR048W |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP21 |
YLR409C |
Subunit of U3-containing 90S preribosome and SSU processome complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSU72 |
YNL222W |
Phosphatase and transcription/RNA-processing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBP6 |
YFR010W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP155 |
YFR040W |
Protein required for function of the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF4 |
YGL115W |
Activating gamma subunit of the AMP-activated Snf1p kinase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TNA1 |
YGR260W |
High affinity nicotinic acid plasma membrane permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STB5 |
YHR178W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPH1 |
YOR270C |
Subunit a of the vacuolar-ATPase V0 domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRT14 |
YIL127C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR115W |
YJR115W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLR156W |
YLR156W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SKI2 |
YLR398C |
Ski complex component and putative RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URA5 |
YML106W |
Major orotate phosphoribosyltransferase (OPRTase) isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SKP2 |
YNL311C |
F-box protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC19 |
YNL113W |
RNA polymerase subunit AC19 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED7 |
YOL135C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTA1 |
YAL043C |
Subunit of holo-CPF |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PUF6 |
YDR496C |
Pumilio-homology domain protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BET2 |
YPR176C |
Beta subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAF130 |
YGR134W |
Subunit of the CCR4-NOT transcriptional regulatory complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIX1 |
YHR197W |
Component of the Rix1 complex and possibly pre-replicative complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IPI3 |
YNL182C |
Component of the Rix1 complex and pre-replicative complexes (pre-RCs) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CLP1 |
YOR250C |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CYR1 |
YJL005W |
Adenylate cyclase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCP1 |
YOL149W |
Subunit of the Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOA1 |
YKL213C |
WD-repeat protein involved in ubiquitin-mediated protein degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ENP1 |
YBR247C |
Protein associated with U3 and U14 snoRNAs |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HRP1 |
YOL123W |
Subunit of cleavage factor I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRR1 |
YCL059C |
Nucleolar protein required for rRNA synthesis and ribosomal assembly |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MAK5 |
YBR142W |
Essential nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HDA3 |
YPR179C |
Subunit of HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUM2 |
YBR057C |
Protein essential for meiotic DNA replication and sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IES5 |
YER092W |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOC4 |
YPR144C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MIR1 |
YJR077C |
Mitochondrial phosphate carrier |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| REF2 |
YDR195W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN13 |
YLR421C |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSI1 |
YMR025W |
Subunit of the Cop9 signalosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTR3 |
YGR158C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRO1 |
YPL084W |
Cytoplasmic class E vacuolar protein sorting (VPS) factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DTD1 |
YDL219W |
D-Tyr-tRNA(Tyr) deacylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NOP6 |
YDL213C |
rRNA-binding protein required for 40S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTC5 |
YDR128W |
Subunit of SEACAT, a subcomplex of the SEA complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IPA1 |
YJR141W |
Protein implicated in pre-mRNA processing and proteasomal degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NDE1 |
YMR145C |
Mitochondrial external NADH dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM8 |
YJR022W |
Lsm (Like Sm) protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CIA1 |
YDR267C |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DEF1 |
YKL054C |
RNAPII degradation factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP3 |
YHR065C |
Protein involved in rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JJJ1 |
YNL227C |
Co-chaperone that stimulates the ATPase activity of Ssa1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PPA2 |
YMR267W |
Mitochondrial inorganic pyrophosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MST27 |
YGL051W |
Putative integral membrane protein, involved in vesicle formation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CST6 |
YIL036W |
Basic leucine zipper (bZIP) transcription factor from ATF/CREB family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CET1 |
YPL228W |
RNA 5'-triphosphatase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MOT2 |
YER068W |
Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTR2 |
YKL186C |
mRNA transport regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP16 |
YKR086W |
DEAH-box RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOM34 |
YNL001W |
Protein that facilitates ribosomal subunit dissociation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBP6 |
YNR038W |
Essential protein involved in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PER33 |
YLR064W |
Protein that localizes to the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCR1 |
YKL150W |
Mitochondrial NADH-cytochrome b5 reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALG1 |
YBR110W |
Mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FRE3 |
YOR381W |
Ferric reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PRI2 |
YKL045W |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL6A |
YML073C |
Ribosomal 60S subunit protein L6A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NCR1 |
YPL006W |
Vacuolar membrane protein involved with Npc2p in sterol trafficking |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LIP1 |
YMR298W |
Ceramide synthase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OSW1 |
YOR255W |
Protein involved in sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EEB1 |
YPL095C |
Acyl-coenzymeA:ethanol O-acyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEO1 |
YIL048W |
Phospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NIT3 |
YLR351C |
Nit protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBP4 |
YGR174C |
Mitochondrial protein required for assembly of cytochrome bc1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DGK1 |
YOR311C |
Diacylglycerol kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS21B |
YJL136C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
