Standard name Systematic name Name description Description
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication
Visualize the interactome of GND1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.167 0.360 NaN
Cytoplasm 0.902 0.676 0.971

GFP localization & abundance

GFP localization GFP abundance
ambiguous, cytoplasm 101000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GND1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0889 (phosphogluconate dehydrogenase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FKH1 YIL131C Forkhead family transcription factor regulation 4 2 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation- exonuclease evidence
STB5 YHR178W Transcription factor regulation 4 4 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, DNA to cDNA expression microarray evidence, RNA-sequencing evidence
GND2 YGR256W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 3 2 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways physical 3 3 1 Affinity Capture-Western, Two-hybrid, PCA
TKL1 YPR074C Transketolase genetic 2 2 2 Synthetic Lethality, Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 2 1 2 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
HAL9 YOL089C Putative transcription factor containing a zinc finger regulation 1 1 1 DNA to cDNA expression microarray evidence
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase genetic 1 1 1 Positive Genetic
ERB1 YMR049C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
GLN1 YPR035W Glutamine synthetase (GS) genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Positive Genetic
RPC40 YPR110C RNA polymerase subunit AC40 physical 1 1 1 Affinity Capture-MS
UTP9 YHR196W Nucleolar protein physical 1 1 1 Affinity Capture-MS
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
HEF3 YNL014W Translational elongation factor EF-3 physical 1 1 1 Affinity Capture-MS
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein physical 1 1 1 Affinity Capture-MS
NAN1 YPL126W U3 snoRNP protein physical 1 1 1 Affinity Capture-MS
SEN15 YMR059W Subunit of the tRNA splicing endonuclease physical 1 1 1 Affinity Capture-MS
RAD16 YBR114W Nucleotide excision repair (NER) protein physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 Affinity Capture-MS
SPT2 YER161C Protein involved in negative regulation of transcription physical 1 1 1 Affinity Capture-MS
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Affinity Capture-MS
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) physical 1 1 1 Affinity Capture-MS
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
GND2 YGR256W 6-phosphogluconate dehydrogenase (decarboxylating) physical 1 1 1 Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) physical 1 1 1 Co-crystal Structure
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) physical 1 1 1 Biochemical Activity
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Reconstituted Complex
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Protein-peptide
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase physical 1 1 1 Protein-peptide
PRP40 YKL012W U1 snRNP protein involved in splicing physical 1 1 1 Protein-peptide
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Protein-peptide
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 PCA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
MYG1 YER156C Protein involved in mitochondrial function physical 1 1 1 Proximity Label-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Synthetic Lethality
TKL2 YBR117C Transketolase genetic 1 1 1 Synthetic Lethality
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Lethality
SDH3 YKL141W Subunit of succinate dehydrogenase and of TIM22 translocase genetic 1 1 1 Positive Genetic
TGL1 YKL140W Steryl ester hydrolase genetic 1 1 1 Negative Genetic
TIM11 YDR322C-A Subunit e of mitochondrial F1F0-ATPase genetic 1 1 1 Negative Genetic
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
SUL2 YLR092W High affinity sulfate permease genetic 1 1 1 Negative Genetic
HEM3 YDL205C Porphobilinogen deaminase genetic 1 1 1 Positive Genetic
VHT1 YGR065C High-affinity plasma membrane H+-biotin (vitamin H) symporter genetic 1 1 1 Positive Genetic
PRS4 YBL068W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP genetic 1 1 1 Negative Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Negative Genetic
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit genetic 1 1 1 Positive Genetic
STR3 YGL184C Peroxisomal cystathionine beta-lyase genetic 1 1 1 Negative Genetic
GPM3 YOL056W Nonfunctional homolog of Gpm1p phosphoglycerate mutase genetic 1 1 1 Positive Genetic
THI7 YLR237W Plasma membrane transporter responsible for the uptake of thiamine genetic 1 1 1 Negative Genetic
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway genetic 1 1 1 Positive Genetic
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 1 1 1 Negative Genetic
ITR1 YDR497C Myo-inositol transporter genetic 1 1 1 Negative Genetic
SPE4 YLR146C Spermine synthase genetic 1 1 1 Positive Genetic
GUP2 YPL189W Probable membrane protein genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
PFK26 YIL107C 6-phosphofructo-2-kinase genetic 1 1 1 Positive Genetic
MET16 YPR167C 3'-phosphoadenylsulfate reductase genetic 1 1 1 Negative Genetic
NHA1 YLR138W Na+/H+ antiporter genetic 1 1 1 Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
VAS1 YGR094W Mitochondrial and cytoplasmic valyl-tRNA synthetase genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
STL1 YDR536W Glycerol proton symporter of the plasma membrane genetic 1 1 1 Negative Genetic
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 1 1 1 Positive Genetic
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase genetic 1 1 1 Negative Genetic
MAE1 YKL029C Mitochondrial malic enzyme genetic 1 1 1 Positive Genetic
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Positive Genetic
ITR2 YOL103W Myo-inositol transporter genetic 1 1 1 Positive Genetic
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Negative Genetic
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
HEM2 YGL040C Aminolevulinate dehydratase genetic 1 1 1 Positive Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Positive Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Negative Genetic
HEM12 YDR047W Uroporphyrinogen decarboxylase genetic 1 1 1 Negative Genetic
HXT15 YDL245C Putative transmembrane polyol transporter genetic 1 1 1 Negative Genetic
GSY2 YLR258W Glycogen synthase genetic 1 1 1 Negative Genetic
SEC59 YMR013C Dolichol kinase genetic 1 1 1 Positive Genetic
LCB3 YJL134W Long-chain base-1-phosphate phosphatase genetic 1 1 1 Negative Genetic
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Positive Genetic
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
ILV6 YCL009C Regulatory subunit of acetolactate synthase genetic 1 1 1 Negative Genetic
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase genetic 1 1 1 Negative Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Positive Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Negative Genetic
NDI1 YML120C NADH:ubiquinone oxidoreductase genetic 1 1 1 Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
HMG2 YLR450W HMG-CoA reductase genetic 1 1 1 Positive Genetic
HXT11 YOL156W Hexose transporter genetic 1 1 1 Positive Genetic
HXT10 YFL011W Hexose transporter genetic 1 1 1 Negative Genetic
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) genetic 1 1 1 Positive Genetic
GNP1 YDR508C Broad specificity amino acid permease genetic 1 1 1 Negative Genetic
SAM3 YPL274W High-affinity S-adenosylmethionine permease genetic 1 1 1 Negative Genetic
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Negative Genetic
SUL1 YBR294W High affinity sulfate permease of the SulP anion transporter family genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
MEP1 YGR121C Ammonium permease genetic 1 1 1 Negative Genetic
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
FOL2 YGR267C GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis genetic 1 1 1 Positive Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
ALD5 YER073W Mitochondrial aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
CYS3 YAL012W Cystathionine gamma-lyase genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Positive Genetic
ARO9 YHR137W Aromatic aminotransferase II physical 1 1 1 Affinity Capture-MS
ENT3 YJR125C Protein containing an N-terminal epsin-like domain physical 1 1 1 Reconstituted Complex
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Negative Genetic
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance physical 1 1 1 Affinity Capture-MS
AMD1 YML035C AMP deaminase genetic 1 1 1 Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
FBP1 YLR377C Fructose-1,6-bisphosphatase genetic 1 1 1 Positive Genetic
ERG25 YGR060W C-4 methyl sterol oxidase genetic 1 1 1 Positive Genetic
DYS1 YHR068W Deoxyhypusine synthase genetic 1 1 1 Positive Genetic
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Positive Genetic
FCY21 YER060W Putative purine-cytosine permease genetic 1 1 1 Positive Genetic
CHA1 YCL064C Catabolic L-serine (L-threonine) deaminase genetic 1 1 1 Negative Genetic
ALD6 YPL061W Cytosolic aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 1 1 1 Phenotypic Suppression
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Negative Genetic
AVT3 YKL146W Vacuolar transporter genetic 1 1 1 Negative Genetic
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Positive Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Positive Genetic
ERR1 YOR393W Putative phosphopyruvate hydratase genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
CTT1 YGR088W Cytosolic catalase T genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Positive Genetic
ASP3-2 YLR157C Cell-wall L-asparaginase II involved in asparagine catabolism genetic 1 1 1 Positive Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
BIO4 YNR057C Dethiobiotin synthetase genetic 1 1 1 Positive Genetic
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 1 1 1 Negative Genetic
FMT1 YBL013W Methionyl-tRNA formyltransferase genetic 1 1 1 Negative Genetic