| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
physical |
12 |
5 |
7 |
Reconstituted Complex, Two-hybrid, Two-hybrid, Co-purification, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western |
| RAD30 |
YDR419W |
DNA polymerase eta |
physical |
9 |
3 |
6 |
Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Reconstituted Complex |
| REV7 |
YIL139C |
Accessory subunit of DNA polymerase zeta |
physical |
9 |
3 |
5 |
Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
8 |
4 |
7 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
8 |
3 |
7 |
Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
physical |
7 |
3 |
7 |
Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex |
| RAD57 |
YDR004W |
Protein that stimulates strand exchange |
genetic |
7 |
3 |
6 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD30 |
YDR419W |
DNA polymerase eta |
genetic |
7 |
2 |
6 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
6 |
2 |
5 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
5 |
3 |
4 |
Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
5 |
2 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
5 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
physical |
5 |
2 |
3 |
Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
| SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
physical |
4 |
3 |
2 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western |
| MPH1 |
YIR002C |
3'-5' DNA helicase involved in error-free bypass of DNA lesions |
genetic |
3 |
3 |
3 |
Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic |
| RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
3 |
1 |
3 |
Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression |
| MMS2 |
YGL087C |
Ubiquitin-conjugating enzyme variant |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic |
| UBC13 |
YDR092W |
E2 ubiquitin-conjugating enzyme |
genetic |
3 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic, Negative Genetic |
| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
physical |
3 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Growth Defect |
| UBI4 |
YLL039C |
Ubiquitin |
physical |
2 |
2 |
2 |
Reconstituted Complex, Co-crystal Structure |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
| MSH6 |
YDR097C |
Protein required for mismatch repair in mitosis and meiosis |
physical |
2 |
2 |
1 |
Reconstituted Complex, Affinity Capture-Western |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
| UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| HOL1 |
YNR055C |
Putative transporter in the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAX2 |
YLR084C |
Protein required for the maintenance of bud site selection |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAP1 |
YNL023C |
Protein that binds to Fpr1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| MGS1 |
YNL218W |
Protein with DNA-dependent ATPase and ssDNA annealing activities |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| APM1 |
YPL259C |
Mu1-like medium subunit of the AP-1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTB1 |
YDR224C |
Histone H2B |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUM1 |
YPL262W |
Fumarase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MAG1 |
YER142C |
3-methyl-adenine DNA glycosylase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NTG1 |
YAL015C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSM2 |
YIL132C |
Subunit of the Shu complex (aka PCSS complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD27 |
YFL023W |
Unconventional prefoldin protein involved in translation initiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COQ5 |
YML110C |
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| EMP46 |
YLR080W |
Integral membrane component of ER-derived COPII-coated vesicles |
genetic |
1 |
1 |
1 |
Positive Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MEI4 |
YER044C-A |
Meiosis-specific protein involved in forming DSBs |
physical |
1 |
1 |
1 |
Two-hybrid |
| ATP10 |
YLR393W |
Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADY4 |
YLR227C |
Structural component of the meiotic outer plaque |
genetic |
1 |
1 |
1 |
Positive Genetic |
| EIS1 |
YMR031C |
Component of the eisosome required for proper eisosome assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MIP1 |
YOR330C |
Mitochondrial DNA polymerase gamma |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PER33 |
YLR064W |
Protein that localizes to the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EUC1 |
YMR111C |
Sequence-specific DNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNP1 |
YIL061C |
Component of U1 snRNP required for mRNA splicing via spliceosome |
physical |
1 |
1 |
1 |
Two-hybrid |
| REV7 |
YIL139C |
Accessory subunit of DNA polymerase zeta |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SML1 |
YML058W |
Ribonucleotide reductase inhibitor |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
physical |
1 |
1 |
1 |
Two-hybrid |
| SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
physical |
1 |
1 |
1 |
Two-hybrid |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA49 |
YNL248C |
RNA polymerase I subunit A49 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF6 |
YGL112C |
Subunit (60 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSC58 |
YLR033W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP185 |
YJL098W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SPP381 |
YBR152W |
mRNA splicing factor, component of U4/U6.U5 tri-snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RNH1 |
YMR234W |
Ribonuclease H1 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SRL2 |
YLR082C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UBC7 |
YMR022W |
Ubiquitin conjugating enzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YDR524C-B |
YDR524C-B |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YFH7 |
YFR007W |
Putative kinase with similarity to the PRK/URK/PANK kinase subfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNR3 |
YIL066C |
Minor isoform of large subunit of ribonucleotide-diphosphate reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMR262W |
YMR262W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR090C |
YCR090C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SFH5 |
YJL145W |
Unusual phosphatidylinositol transfer protein (PITP) that binds heme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJL163C |
YJL163C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VBA1 |
YMR088C |
Permease of basic amino acids in the vacuolar membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSR3 |
YOR006C |
Protein required for 20S pre-rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS10B |
YMR230W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPS11A |
YDR025W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YNL042W-B |
YNL042W-B |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMR160W |
YMR160W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MEI5 |
YPL121C |
Meiosis-specific protein involved in meiotic recombination |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JHD2 |
YJR119C |
JmjC domain family histone demethylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AHK1 |
YDL073W |
Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEM12 |
YDR047W |
Uroporphyrinogen decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MNN5 |
YJL186W |
Alpha-1,2-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DNF2 |
YDR093W |
Aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COQ2 |
YNR041C |
Para hydroxybenzoate polyprenyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NTG2 |
YOL043C |
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CCW12 |
YLR110C |
Cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AVL9 |
YLR114C |
Conserved protein involved in exocytic transport from the Golgi |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HAL1 |
YPR005C |
Cytoplasmic protein involved in halotolerance |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MDM35 |
YKL053C-A |
Mitochondrial intermembrane space protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| COA6 |
YMR244C-A |
Protein involved in cytochrome c oxidase (Complex IV) assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET22 |
YOL064C |
Bisphosphate-3'-nucleotidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSH1 |
YHR120W |
DNA-binding protein of the mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRY3 |
YJL078C |
GPI-anchored cell wall protein involved in export of sterols |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRS4 |
YKR019C |
EH domain-containing protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
