BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
WHI2 |
YOR043W |
Negative regulator of TORC1 in response to limiting leucine |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
BUD20 |
YLR074C |
C2H2-type zinc finger protein required for ribosome assembly |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
PHO5 |
YBR093C |
Repressible acid phosphatase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
GRS1 |
YBR121C |
Cytoplasmic and mitochondrial glycyl-tRNA synthase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
YDL206W |
YDL206W |
Putative protein of unknown function |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
HBT1 |
YDL223C |
Shmoo tip protein, substrate of Hub1p ubiquitin-like protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
PMP3 |
YDR276C |
Small plasma membrane protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
RAD34 |
YDR314C |
Protein involved in nucleotide excision repair (NER) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
PEA2 |
YER149C |
Coiled-coil 12S polarisome subunit |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
MRX20 |
YFR045W |
Putative mitochondrial transport protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
YGL081W |
YGL081W |
Putative protein of unknown function |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
CUE3 |
YGL110C |
Subunit of ribosome-associated quality control trigger complex (RQT) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
RPE1 |
YJL121C |
D-ribulose-5-phosphate 3-epimerase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
HXT8 |
YJL214W |
Protein of unknown function with similarity to hexose transporters |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
HIT1 |
YJR055W |
Protein involved in C/D snoRNP assembly |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
TCB2 |
YNL087W |
ER protein involved in ER-plasma membrane tethering |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
LDB19 |
YOR322C |
Alpha-arrestin, Ub-ligase adaptor for Rsp5p |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
PRM3 |
YPL192C |
Protein required for nuclear envelope fusion during karyogamy |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
CLN2 |
YPL256C |
G1 cyclin involved in regulation of the cell cycle |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
AIM34 |
YMR003W |
Protein of unknown function |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
PEX22 |
YAL055W |
Putative peroxisomal membrane protein |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
TYR1 |
YBR166C |
Prephenate dehydrogenase involved in tyrosine biosynthesis |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
YDR248C |
YDR248C |
Putative gluconokinase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
SPF1 |
YEL031W |
P-type ATPase, ion transporter of the ER membrane |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
PDA1 |
YER178W |
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
EMP24 |
YGL200C |
Component of the p24 complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
HAP2 |
YGL237C |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
HPM1 |
YIL110W |
AdoMet-dependent methyltransferase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
RPA34 |
YJL148W |
RNA polymerase I subunit A34.5 |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
ELO1 |
YJL196C |
Elongase I, medium-chain acyl elongase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
NUC1 |
YJL208C |
Major mitochondrial nuclease |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
CNB1 |
YKL190W |
Calcineurin B |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
UTH1 |
YKR042W |
Mitochondrial inner membrane protein |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
FPS1 |
YLL043W |
Aquaglyceroporin, plasma membrane channel |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
SKI2 |
YLR398C |
Ski complex component and putative RNA helicase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
PKR1 |
YMR123W |
V-ATPase assembly factor |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
PFK2 |
YMR205C |
Beta subunit of heterooctameric phosphofructokinase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
MDM38 |
YOL027C |
Membrane-associated mitochondrial ribosome receptor |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
VPS5 |
YOR069W |
Nexin-1 homolog |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
STE12 |
YHR084W |
Transcription factor that is activated by a MAPK signaling cascade |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
RGM1 |
YMR182C |
Putative zinc finger DNA binding transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SWI5 |
YDR146C |
Transcription factor that recruits Mediator and Swi/Snf complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
CAP1 |
YKL007W |
Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ATG18 |
YFR021W |
Phosphoinositide binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ABP1 |
YCR088W |
Actin-binding protein of the cortical actin cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
KSP1 |
YHR082C |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ENO2 |
YHR174W |
Enolase II, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PGK1 |
YCR012W |
3-phosphoglycerate kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
physical |
1 |
1 |
1 |
Biochemical Activity |
SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
physical |
1 |
1 |
1 |
Biochemical Activity |
TOS3 |
YGL179C |
Protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
TOR1 |
YJR066W |
PIK-related protein kinase and rapamycin target |
physical |
1 |
1 |
1 |
Co-fractionation |
TOR2 |
YKL203C |
PIK-related protein kinase and rapamycin target |
physical |
1 |
1 |
1 |
Co-fractionation |
FLC2 |
YAL053W |
Putative calcium channel involved in calcium release under hypotonic |
physical |
1 |
1 |
1 |
PCA |
HEK2 |
YBL032W |
RNA binding protein involved in asymmetric localization of ASH1 mRNA |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
YHK8 |
YHR048W |
Presumed antiporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
PCA |
HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
physical |
1 |
1 |
1 |
Reconstituted Complex |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HMT1 |
YBR034C |
Nuclear SAM-dependent mono- and asymmetric methyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PSG1 |
YKL077W |
Protein that promotes the transport and maturation of Pma1 with Exp1 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MCA1 |
YOR197W |
Ca2+-dependent cysteine protease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SCS3 |
YGL126W |
Protein required for normal ER membrane biosynthesis in response to ER |
physical |
1 |
1 |
1 |
PCA |
NNR1 |
YNL200C |
NADHX epimerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PSY2 |
YNL201C |
Subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SPS19 |
YNL202W |
Peroxisomal 2,4-dienoyl-CoA reductase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
SPS18 |
YNL204C |
Protein of unknown function, contains a putative zinc-binding domain |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PEX6 |
YNL329C |
AAA-peroxin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
PDI1 |
YCL043C |
Protein disulfide isomerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
ECM21 |
YBL101C |
Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
FIG2 |
YCR089W |
Cell wall adhesin, expressed specifically during mating |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PDR16 |
YNL231C |
Phosphatidylinositol transfer protein (PITP) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
CRZ1 |
YNL027W |
Transcription factor, activates transcription of stress response genes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
VPS21 |
YOR089C |
Endosomal Rab family GTPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
GUP1 |
YGL084C |
Plasma membrane protein involved in remodeling GPI anchors |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS64 |
YDR200C |
Protein required for cytoplasm to vacuole targeting of proteins |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG6 |
YML008C |
Delta(24)-sterol C-methyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PIL1 |
YGR086C |
Eisosome core component |
genetic |
1 |
1 |
1 |
Positive Genetic |
VTA1 |
YLR181C |
Multivesicular body (MVB) protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
CSH1 |
YBR161W |
Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
SST2 |
YLR452C |
GTPase-activating protein for Gpa1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
TRE1 |
YPL176C |
Transferrin receptor-like protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SUR2 |
YDR297W |
Sphinganine C4-hydroxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
FKS1 |
YLR342W |
Catalytic subunit of 1,3-beta-D-glucan synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
1 |
1 |
1 |
Positive Genetic |
SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RGD1 |
YBR260C |
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FTH1 |
YBR207W |
Putative high affinity iron transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
GGA1 |
YDR358W |
Golgi-localized protein with homology to gamma-adaptin |
genetic |
1 |
1 |
1 |
Negative Genetic |
MID1 |
YNL291C |
Stretch-activated Ca2+-permeable cation channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
WSC3 |
YOL105C |
Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
LCB5 |
YLR260W |
Minor sphingoid long-chain base kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIT1 |
YEL065W |
Ferrioxamine B transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
IPT1 |
YDR072C |
Inositolphosphotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ENT5 |
YDR153C |
Protein containing an N-terminal epsin-like domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
FET3 |
YMR058W |
Ferro-O2-oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOK1 |
YJL093C |
Outward-rectifier potassium channel of the plasma membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
TCB3 |
YML072C |
Cortical ER protein involved in ER-plasma membrane tethering |
genetic |
1 |
1 |
1 |
Negative Genetic |
THI7 |
YLR237W |
Plasma membrane transporter responsible for the uptake of thiamine |
genetic |
1 |
1 |
1 |
Negative Genetic |
NRD1 |
YNL251C |
RNA-binding subunit of Nrd1 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
ECM2 |
YBR065C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
SCH9 |
YHR205W |
AGC family protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
BUD6 |
YLR319C |
Actin- and formin-interacting protein |
physical |
1 |
1 |
1 |
PCA |
CAP2 |
YIL034C |
Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ALP1 |
YNL270C |
Arginine transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |