Standard name Systematic name Name description Description
FET3 YMR058W Ferro-O2-oxidoreductase Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
Visualize the interactome of FET3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 34

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.915 0.884 0.956
Cort. Patches 0.098 0.089 0.067
Cytoplasm 0.098 0.129 NaN

GFP localization & abundance

GFP localization GFP abundance
ER, cell periphery, bud 1050

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
FET3 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_1178 (iron (II) transport)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 9 6 7 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Rescue
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 4 3 3 Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FTR1 YER145C High affinity iron permease physical 3 3 3 Two-hybrid, PCA, FRET
FKH2 YNL068C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 2 2 2 DNA to cDNA expression microarray evidence, northern blot evidence
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Rescue, Positive Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PFY1 YOR122C Profilin genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
ENB1 YOL158C Ferric enterobactin transmembrane transporter genetic 2 2 2 Synthetic Lethality, Synthetic Rescue
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
FRE1 YLR214W Ferric reductase and cupric reductase genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 2 1 2 Negative Genetic, Negative Genetic
MPO1 YGL010W Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids genetic 2 1 2 Negative Genetic, Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 2 1 2 Negative Genetic, Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 2 2 1 Phenotypic Suppression, Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 2 1 Phenotypic Suppression, Synthetic Growth Defect
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ADA2 YDR448W Transcription coactivator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GRE3 YHR104W Aldose reductase genetic 2 1 1 Negative Genetic, Negative Genetic
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 DNA to cDNA expression microarray evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ROX1 YPR065W Heme-dependent repressor of hypoxic genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAP1 YLR256W Zinc finger transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
INO4 YOL108C Transcription factor involved in phospholipid synthesis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SMP1 YBR182C MADS-box transcription factor involved in osmotic stress response regulation 1 1 1 DNA to cDNA expression microarray evidence
CUP2 YGL166W Copper-binding transcription factor regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Dosage Growth Defect
ARP2 YDL029W Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
HYM1 YKL189W Component of the RAM signaling network physical 1 1 1 Affinity Capture-MS
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase physical 1 1 1 Affinity Capture-MS
RER1 YCL001W Protein involved in retention of membrane proteins physical 1 1 1 Affinity Capture-Western
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex physical 1 1 1 PCA
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 PCA
IFA38 YBR159W Microsomal beta-keto-reductase physical 1 1 1 PCA
SHR3 YDL212W Endoplasmic reticulum packaging chaperone physical 1 1 1 PCA
MST27 YGL051W Putative integral membrane protein, involved in vesicle formation physical 1 1 1 PCA
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors physical 1 1 1 PCA
YHR140W YHR140W Endoplasmic reticulum protein physical 1 1 1 PCA
SNL1 YIL016W Ribosome-associated protein physical 1 1 1 PCA
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein physical 1 1 1 PCA
LAC1 YKL008C Ceramide synthase component physical 1 1 1 PCA
YET1 YKL065C Endoplasmic reticulum transmembrane protein physical 1 1 1 PCA
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit physical 1 1 1 PCA
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein physical 1 1 1 PCA
PFA4 YOL003C Palmitoyltransferase with autoacylation activity physical 1 1 1 PCA
PNS1 YOR161C Protein of unknown function physical 1 1 1 PCA
SLY41 YOR307C Protein involved in ER-to-Golgi transport physical 1 1 1 PCA
SEC62 YPL094C Essential subunit of Sec63 complex physical 1 1 1 PCA
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' physical 1 1 1 PCA
YPL264C YPL264C Endoplasmic reticulum protein of unknown function physical 1 1 1 PCA
SAM3 YPL274W High-affinity S-adenosylmethionine permease physical 1 1 1 PCA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
FET5 YFL041W Multicopper oxidase genetic 1 1 1 Dosage Rescue
SIT1 YEL065W Ferrioxamine B transporter genetic 1 1 1 Phenotypic Enhancement
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Phenotypic Enhancement
SMF3 YLR034C Putative divalent metal ion transporter involved in iron homeostasis genetic 1 1 1 Synthetic Growth Defect
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Synthetic Growth Defect
FLC1 YPL221W Flavin adenine dinucleotide transporter genetic 1 1 1 Dosage Rescue
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Dosage Rescue
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Synthetic Rescue
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Synthetic Growth Defect
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Synthetic Growth Defect
MSR1 YHR091C Mitochondrial arginyl-tRNA synthetase genetic 1 1 1 Synthetic Growth Defect
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Lethality
RIB4 YOL143C Lumazine synthase (DMRL synthase) genetic 1 1 1 Synthetic Lethality
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Growth Defect
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
YPK2 YMR104C AGC-type S/T protein kinase genetic 1 1 1 Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Dosage Growth Defect
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
OPT2 YPR194C Oligopeptide transporter genetic 1 1 1 Synthetic Lethality
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Positive Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Positive Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Positive Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Positive Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
MRPL32 YCR003W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
RSM28 YDR494W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Negative Genetic
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Rescue
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Rescue
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway physical 1 1 1 Affinity Capture-MS
AIP1 YMR092C Actin cortical patch component genetic 1 1 1 Negative Genetic
CHS1 YNL192W Chitin synthase I genetic 1 1 1 Negative Genetic
CTR1 YPR124W High-affinity copper transporter of plasma membrane genetic 1 1 1 Synthetic Growth Defect
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway physical 1 1 1 Affinity Capture-MS
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis physical 1 1 1 PCA
ELO3 YLR372W Elongase physical 1 1 1 PCA
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Growth Defect
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase physical 1 1 1 PCA
ERV29 YGR284C Protein localized to COPII-coated vesicles physical 1 1 1 PCA
BSD2 YBR290W Heavy metal ion homeostasis protein genetic 1 1 1 Negative Genetic
ALG1 YBR110W Mannosyltransferase physical 1 1 1 PCA
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
CHO1 YER026C Phosphatidylserine synthase physical 1 1 1 PCA
ELO1 YJL196C Elongase I, medium-chain acyl elongase physical 1 1 1 PCA