Standard name Systematic name Name description Description
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector Rho-family GTPase interacting protein and Cdc42p effector; required with Gic1p for cell polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit
Visualize the interactome of GIC2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 30

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.969 0.93 0.922
Mito 0.061 NaN NaN
Cell Periphery NaN NaN 0.083

GFP localization & abundance

GFP localization GFP abundance
ambiguous, cytoplasm, bud 1130

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GIC2 0 1 0 4 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC42 YLR229C Small rho-like GTPase physical 11 3 10 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Reconstituted Complex
CDC42 YLR229C Small rho-like GTPase genetic 8 6 6 Synthetic Lethality, Dosage Rescue, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector genetic 6 3 5 Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
FKH2 YNL068C Forkhead family transcription factor regulation 3 3 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
RSR1 YGR152C Ras-type GTPase genetic 3 2 3 Synthetic Lethality, Dosage Rescue, Dosage Rescue
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 3 3 2 Dosage Rescue, Synthetic Rescue, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Dosage Growth Defect
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 3 2 2 Two-hybrid, Two-hybrid, Reconstituted Complex
BEM1 YBR200W Protein containing SH3-domains genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ATP10 YLR393W Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MLF3 YNL074C Serine-rich protein of unknown function genetic 3 2 1 Synthetic Growth Defect, Dosage Rescue, Dosage Rescue
VHS2 YIL135C Regulator of septin dynamics genetic 3 2 1 Synthetic Growth Defect, Dosage Rescue, Dosage Rescue
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression regulation 2 2 2 chromatin immunoprecipitation-chip evidence, reporter gene assay evidence
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
AXL2 YIL140W Integral plasma membrane protein genetic 2 2 2 Dosage Rescue, Synthetic Lethality
BNI1 YNL271C Formin genetic 2 2 2 Synthetic Lethality, Dosage Rescue
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex physical 2 2 2 Two-hybrid, Affinity Capture-MS
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 2 2 2 Synthetic Rescue, Dosage Rescue
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 2 1 2 Negative Genetic, Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 2 1 2 Positive Genetic, Positive Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 2 1 2 Positive Genetic, Positive Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 2 1 2 Positive Genetic, Positive Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 2 2 1 Two-hybrid, Affinity Capture-Western
BUD6 YLR319C Actin- and formin-interacting protein genetic 2 2 1 Dosage Lethality, Synthetic Lethality
SPA2 YLL021W Component of the polarisome genetic 2 2 1 Dosage Lethality, Synthetic Lethality
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) physical 2 1 1 Two-hybrid, Two-hybrid
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 2 1 1 Negative Genetic, Negative Genetic
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector physical 2 1 1 Two-hybrid, Two-hybrid
YIR016W YIR016W Putative protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 2 1 1 Negative Genetic, Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor regulation 1 1 1 DNA to cDNA expression microarray evidence
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PUT3 YKL015W Transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RLM1 YPL089C MADS-box transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Two-hybrid
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 1 1 1 Two-hybrid
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
BNI1 YNL271C Formin physical 1 1 1 Affinity Capture-Western
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Synthetic Lethality
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Growth Defect
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Negative Genetic
CYC8 YBR112C General transcriptional co-repressor genetic 1 1 1 Dosage Rescue
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Growth Defect
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
DUF1 YOL087C Ubiquitin-binding protein of unknown function genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Dosage Rescue
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Synthetic Rescue
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 1 1 1 Two-hybrid
BUD5 YCR038C GTP/GDP exchange factor for Rsr1p (Bud1p) genetic 1 1 1 Synthetic Lethality
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Dosage Lethality
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 1 1 1 Synthetic Growth Defect
BUD2 YKL092C GTPase activating factor for Rsr1p/Bud1p genetic 1 1 1 Synthetic Lethality
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Positive Genetic
BUD6 YLR319C Actin- and formin-interacting protein physical 1 1 1 Two-hybrid
PEA2 YER149C Coiled-coil 12S polarisome subunit physical 1 1 1 Two-hybrid
STE50 YCL032W Adaptor protein for various signaling pathways physical 1 1 1 Two-hybrid
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles physical 1 1 1 Two-hybrid
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth physical 1 1 1 Two-hybrid
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth physical 1 1 1 Two-hybrid
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) physical 1 1 1 Two-hybrid
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Dosage Growth Defect
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Reconstituted Complex
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation physical 1 1 1 Affinity Capture-Western
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SSD1 YDR293C Translational repressor genetic 1 1 1 Phenotypic Suppression
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Dosage Lethality
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
TUP1 YCR084C General repressor of transcription in complex with Cyc8p genetic 1 1 1 Dosage Rescue
SKG6 YHR149C Integral membrane protein genetic 1 1 1 Dosage Rescue
TOS2 YGR221C Protein involved in localization of Cdc24p to the site of bud growth genetic 1 1 1 Dosage Rescue
MSB2 YGR014W Mucin family member involved in various signaling pathways genetic 1 1 1 Dosage Rescue
MSB1 YOR188W Protein of unknown function genetic 1 1 1 Dosage Rescue
MSB3 YNL293W Rab GTPase-activating protein genetic 1 1 1 Dosage Rescue
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Dosage Rescue
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Dosage Growth Defect
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Growth Defect
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Positive Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
YCR090C YCR090C Putative protein of unknown function genetic 1 1 1 Positive Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
PET122 YER153C Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
YFL051C YFL051C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MTO1 YGL236C Mitochondrial protein genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic
HAP4 YKL109W Transcription factor genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
YOR008C-A YOR008C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
MNE1 YOR350C Protein involved in splicing Group I aI5-beta intron from COX1 mRNA genetic 1 1 1 Negative Genetic
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
RAX1 YOR301W Protein involved in establishing bud site selection genetic 1 1 1 Synthetic Lethality
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 1 1 1 Two-hybrid
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Negative Genetic
AIM11 YER093C-A Protein of unknown function genetic 1 1 1 Negative Genetic
ECM7 YLR443W Putative integral membrane protein with a role in calcium uptake genetic 1 1 1 Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
CYC2 YOR037W Mitochondrial peripheral inner membrane protein genetic 1 1 1 Negative Genetic
FCY2 YER056C Purine-cytosine permease genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic