Standard name Systematic name Name description Description
HST4 YDR191W NAD(+)-dependent protein deacetylase NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3
Visualize the interactome of HST4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1 242

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.689 0.672 0.897
Mito 0.253 0.056 NaN
Nucleus 0.138 0.217 NaN
Vac/Vac Memb 0.065 0.106 NaN
Budneck NaN NaN 0.056

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 377

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HST4 5 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0767 (NAD nucleosidase nuclear)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 24 4 16 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Enhancement
DIA2 YOR080W Origin-binding F-box protein genetic 7 3 4 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 4 3 4 Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 4 3 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions physical 4 4 2 Affinity Capture-MS, Protein-peptide, Biochemical Activity, Reconstituted Complex
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
RTT109 YLL002W Histone acetyltransferase genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
SLX4 YLR135W Endonuclease involved in processing DNA genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 genetic 3 3 1 Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement
CDC45 YLR103C DNA replication initiation factor genetic 2 2 2 Synthetic Lethality, Synthetic Rescue
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 2 2 Negative Genetic, Synthetic Lethality
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 2 2 Dosage Rescue, Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
HHT1 YBR010W Histone H3 genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
CTF4 YPR135W Chromatin-associated protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 2 1 2 Negative Genetic, Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 2 1 2 Negative Genetic, Negative Genetic
RAD24 YER173W Checkpoint protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
RAD17 YOR368W Checkpoint protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 2 2 1 Protein-peptide, Reconstituted Complex
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
IDP1 YDL066W Mitochondrial NADP-specific isocitrate dehydrogenase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
YAT1 YAR035W Outer mitochondrial carnitine acetyltransferase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
BDF1 YLR399C BET family transcriptional regulator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YOX1 YML027W Homeobox transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Rescue
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
HHF1 YBR009C Histone H4 genetic 1 1 1 Synthetic Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Rescue
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Synthetic Lethality
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
BRF1 YGR246C TFIIIB B-related factor genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Rescue
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Synthetic Rescue
FBP1 YLR377C Fructose-1,6-bisphosphatase genetic 1 1 1 Phenotypic Enhancement
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Synthetic Rescue
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Synthetic Rescue
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases physical 1 1 1 Biochemical Activity
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Rescue
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Synthetic Rescue
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Lethality
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Lethality
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Lethality
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Lethality
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Lethality
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Phenotypic Enhancement
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Enhancement
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B genetic 1 1 1 Negative Genetic
YGR016W YGR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YLL053C YLL053C Putative protein genetic 1 1 1 Negative Genetic
YPS1 YLR120C Aspartic protease genetic 1 1 1 Negative Genetic
YOR012W YOR012W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Synthetic Lethality
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Dosage Rescue
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 1 1 1 Synthetic Rescue
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Rescue
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Synthetic Rescue
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Rescue
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Phenotypic Enhancement
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Negative Genetic