Standard name Systematic name Name description Description
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication
Visualize the interactome of SKM1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 48

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.952 0.989 0.958
Mito 0.143 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
ambiguous 238

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SKM1 3 0 1 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway physical 3 3 3 Two-hybrid, Affinity Capture-MS, Protein-peptide
CDC42 YLR229C Small rho-like GTPase physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 2 2 2 Dosage Rescue, Synthetic Growth Defect
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
PTC1 YDL006W Type 2C protein phosphatase (PP2C) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Negative Genetic, Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Negative Genetic, Negative Genetic
YHP1 YDR451C Homeobox transcriptional repressor genetic 2 1 2 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 2 Negative Genetic, Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 2 1 2 Negative Genetic, Negative Genetic
NRG1 YDR043C Transcriptional repressor genetic 2 1 2 Negative Genetic, Negative Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 2 1 2 Negative Genetic, Negative Genetic
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase genetic 2 1 2 Negative Genetic, Negative Genetic
DIA1 YMR316W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase genetic 2 1 2 Negative Genetic, Negative Genetic
GPX2 YBR244W Phospholipid hydroperoxide glutathione peroxidase genetic 2 1 2 Negative Genetic, Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 2 1 2 Negative Genetic, Negative Genetic
MCP1 YOR228C Mitochondrial protein of unknown function involved in lipid homeostas genetic 2 1 2 Negative Genetic, Negative Genetic
LEE1 YPL054W Zinc-finger protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
ICL2 YPR006C 2-methylisocitrate lyase of the mitochondrial matrix genetic 2 1 2 Negative Genetic, Negative Genetic
AVT7 YIL088C Vacuolar amino acid transporter genetic 2 1 2 Negative Genetic, Negative Genetic
PES4 YFR023W Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation genetic 2 1 2 Negative Genetic, Negative Genetic
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAP1 YLR256W Zinc finger transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CWC2 YDL209C Member of the NineTeen Complex (NTC) physical 1 1 1 Biochemical Activity
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
RIX7 YLL034C Putative ATPase of the AAA family genetic 1 1 1 Dosage Growth Defect
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Synthetic Rescue
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases physical 1 1 1 Biochemical Activity
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Biochemical Activity
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BEM1 YBR200W Protein containing SH3-domains physical 1 1 1 Protein-peptide
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Positive Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Positive Genetic
ELP2 YGR200C Subunit of Elongator complex physical 1 1 1 Reconstituted Complex
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) physical 1 1 1 Biochemical Activity
HHF1 YBR009C Histone H4 physical 1 1 1 Biochemical Activity
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Biochemical Activity
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
MRP4 YHL004W Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Biochemical Activity
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Biochemical Activity
MYO4 YAL029C Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Dosage Growth Defect
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase physical 1 1 1 Biochemical Activity
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
BLM10 YFL007W Proteasome activator genetic 1 1 1 Positive Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RPC53 YDL150W RNA polymerase III subunit C53 genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
BGL2 YGR282C Endo-beta-1,3-glucanase physical 1 1 1 Biochemical Activity
IST2 YBR086C Cortical ER protein involved in ER-plasma membrane (PM) tethering physical 1 1 1 Biochemical Activity
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Negative Genetic
TPD3 YAL016W Regulatory subunit A of the heterotrimeric PP2A complex physical 1 1 1 Affinity Capture-MS
UBP9 YER098W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions physical 1 1 1 Biochemical Activity
SRO7 YPR032W Effector of Rab GTPase Sec4p physical 1 1 1 Biochemical Activity
SOL2 YCR073W-A Protein with a possible role in tRNA export physical 1 1 1 Biochemical Activity
YNL284C-A YNL284C-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Biochemical Activity
YML037C YML037C Putative protein of unknown function physical 1 1 1 Biochemical Activity
YML096W YML096W Putative protein with similarity to asparagine synthetases physical 1 1 1 Biochemical Activity
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Biochemical Activity
SWI6 YLR182W Transcription cofactor physical 1 1 1 Biochemical Activity
YPL088W YPL088W Putative aryl alcohol dehydrogenase physical 1 1 1 Biochemical Activity
SPE1 YKL184W Ornithine decarboxylase physical 1 1 1 Biochemical Activity
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
STE3 YKL178C Receptor for a factor pheromone physical 1 1 1 Biochemical Activity
YPS6 YIR039C Putative GPI-anchored aspartic protease physical 1 1 1 Biochemical Activity
SUT1 YGL162W Zn(II)2Cys6 family transcription factor physical 1 1 1 Affinity Capture-Western
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor physical 1 1 1 PCA
TRM112 YNR046W Protein involved in methylation of tRNA, rRNA, and translation factors physical 1 1 1 Reconstituted Complex
TRP3 YKL211C Indole-3-glycerol-phosphate synthase physical 1 1 1 Reconstituted Complex
SSF2 YDR312W Protein required for ribosomal large subunit maturation physical 1 1 1 Affinity Capture-Western
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Phenotypic Enhancement
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YBL111C YBL111C Helicase-like protein encoded within the telomeric Y' element genetic 1 1 1 Dosage Growth Defect
YCR102C YCR102C Putative quinone oxidoreductase genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
UGA4 YDL210W GABA (gamma-aminobutyrate) permease genetic 1 1 1 Negative Genetic
TRR2 YHR106W Mitochondrial thioredoxin reductase genetic 1 1 1 Negative Genetic
TPO5 YKL174C Protein involved in excretion of putrescine and spermidine genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
HMG2 YLR450W HMG-CoA reductase physical 1 1 1 Affinity Capture-MS
DUT1 YBR252W Deoxyuridine triphosphate diphosphatase (dUTPase) physical 1 1 1 Reconstituted Complex
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p physical 1 1 1 Biochemical Activity
APM4 YOL062C Cargo-binding mu subunit of AP-2 physical 1 1 1 Biochemical Activity
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
PCL10 YGL134W Pho85p cyclin physical 1 1 1 Biochemical Activity
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
MGL2 YMR210W Monoacylglycerol and triacylglycerol lipase physical 1 1 1 Biochemical Activity
RPS24B YIL069C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Biochemical Activity
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
MCM3 YEL032W Protein involved in DNA replication physical 1 1 1 Biochemical Activity
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 1 1 1 Biochemical Activity
MDV1 YJL112W Peripheral protein of cytosolic face of mitochondrial outer membrane genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex physical 1 1 1 Reconstituted Complex
LYS21 YDL131W Homocitrate synthase isozyme physical 1 1 1 Biochemical Activity
KIP1 YBL063W Kinesin-related motor protein genetic 1 1 1 Dosage Growth Defect
EHT1 YBR177C Octanoyl-CoA:ethanol acyltransferase physical 1 1 1 Reconstituted Complex
BNA1 YJR025C 3-hydroxyanthranilic acid dioxygenase physical 1 1 1 Reconstituted Complex
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
SAS10 YDL153C Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Biochemical Activity
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
OPY2 YPR075C Integral membrane protein that acts as a membrane anchor for Ste50p genetic 1 1 1 Negative Genetic
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Phenotypic Suppression
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Negative Genetic
RCM1 YNL022C rRNA m5C methyltransferase physical 1 1 1 Biochemical Activity
SCT1 YBL011W Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase physical 1 1 1 Biochemical Activity
RNH70 YGR276C 3'-5' exoribonuclease physical 1 1 1 Biochemical Activity
GAS3 YMR215W Putative 1,3-beta-glucanosyltransferase physical 1 1 1 Biochemical Activity
RGD3 YHR182W GTPase activating protein (GAP) for Rho3p, involved in cell polarity g physical 1 1 1 Biochemical Activity
APS2 YJR058C Small subunit of the clathrin-associated adaptor complex AP-2 physical 1 1 1 Biochemical Activity
SCS22 YBL091C-A Protein involved in regulation of phospholipid metabolism physical 1 1 1 Biochemical Activity
HST4 YDR191W NAD(+)-dependent protein deacetylase physical 1 1 1 Biochemical Activity
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
HEM2 YGL040C Aminolevulinate dehydratase genetic 1 1 1 Negative Genetic
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
COS1 YNL336W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Negative Genetic
BUD16 YEL029C Putative pyridoxal kinase physical 1 1 1 Reconstituted Complex
PMT7 YDR307W Putative protein mannosyltransferase similar to Pmt1p genetic 1 1 1 Dosage Growth Defect
SHE10 YGL228W Protein involved in outer spore wall assembly genetic 1 1 1 Dosage Growth Defect