Standard name Systematic name Name description Description
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p Alpha arrestin, Ub-ligase adaptor for Rsp5p; controls nutrient limitation-mediated endosomal recycling of the Gap1p amino acid permease; PY motif-containing adaptor involved in substrate-induced, Rsp5p-mediated ubiquitination and endocytosis of select plasma membrane localized amino acid transporters, such as Dip5p and Put4p; phosphorylated by Npr1p and by the Pcl7p-Pho85p cyclin-CDK complex; interacts with AP-1 subunit Apl4p
Visualize the interactome of ALY2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.125 NaN 0.106
Cytoplasm 0.958 0.96 0.963

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ALY2 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 10 5 8 Affinity Capture-MS, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Protein-peptide, Affinity Capture-Western, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ALY1 YKR021W Alpha arrestin, substrate of calcineurin genetic 3 2 3 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
APL1 YJR005W Beta-adaptin physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
MPS1 YDL028C Dual-specificity kinase physical 2 2 2 Biochemical Activity, Reconstituted Complex
PHO85 YPL031C Cyclin-dependent kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
SLA1 YBL007C Cytoskeletal protein binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Negative Genetic, Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 2 1 2 Negative Genetic, Negative Genetic
RSM7 YJR113C Mitochondrial ribosomal protein of the small subunit genetic 2 1 2 Negative Genetic, Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 2 1 2 Negative Genetic, Negative Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 2 1 1 Reconstituted Complex, Reconstituted Complex
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
AKL1 YBR059C Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
PCL6 YER059W Pho85p cyclin of the Pho80p subfamily physical 1 1 1 Two-hybrid
PUT4 YOR348C Proline permease physical 1 1 1 Two-hybrid
PCL7 YIL050W Pho85p cyclin of the Pho80p subfamily physical 1 1 1 Affinity Capture-Western
LSM5 YER146W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
APL3 YBL037W Alpha-adaptin physical 1 1 1 Affinity Capture-MS
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Biochemical Activity
CMK1 YFR014C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Biochemical Activity
PTK2 YJR059W Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Biochemical Activity
RIM11 YMR139W Protein kinase physical 1 1 1 Biochemical Activity
SKY1 YMR216C SR protein kinase (SRPK) physical 1 1 1 Biochemical Activity
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Biochemical Activity
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 1 1 1 Biochemical Activity
TOS3 YGL179C Protein kinase physical 1 1 1 Biochemical Activity
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
PKP2 YGL059W Mitochondrial protein kinase physical 1 1 1 Biochemical Activity
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization physical 1 1 1 Two-hybrid
GAP1 YKR039W General amino acid permease physical 1 1 1 Affinity Capture-Western
NPR1 YNL183C Protein kinase physical 1 1 1 Affinity Capture-Western
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Affinity Capture-Western
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex physical 1 1 1 Affinity Capture-Western
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 1 1 1 Synthetic Rescue
APL4 YPR029C Gamma-adaptin physical 1 1 1 Affinity Capture-Western
DIP5 YPL265W Dicarboxylic amino acid permease physical 1 1 1 Affinity Capture-Western
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 1 1 1 Biochemical Activity
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 1 1 1 Biochemical Activity
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Co-purification
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Co-purification
CNA1 YLR433C Calcineurin A physical 1 1 1 Biochemical Activity
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p physical 1 1 1 Two-hybrid
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 1 1 1 Negative Genetic
TMA17 YDL110C Regulatory gamma subunit of fatty acid synthase (FAS) genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Synthetic Rescue
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Rescue
TRP1 YDR007W Phosphoribosylanthranilate isomerase genetic 1 1 1 Dosage Rescue
TAT1 YBR069C Amino acid transporter for valine, leucine, isoleucine, and tyrosine genetic 1 1 1 Synthetic Rescue
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Phenotypic Enhancement
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex genetic 1 1 1 Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
SHE9 YDR393W Protein required for normal mitochondrial morphology genetic 1 1 1 Negative Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
KAP123 YER110C Karyopherin beta genetic 1 1 1 Negative Genetic
RBG2 YGR173W Protein with a role in translation genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
YLR012C YLR012C Putative protein of unknown function genetic 1 1 1 Negative Genetic
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
CGI121 YML036W Component of the EKC/KEOPS complex genetic 1 1 1 Negative Genetic
GAS3 YMR215W Putative 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
COX7 YMR256C Subunit VII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
URK1 YNR012W Uridine/cytidine kinase genetic 1 1 1 Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
PRO1 YDR300C Gamma-glutamyl kinase genetic 1 1 1 Phenotypic Suppression
CAR2 YLR438W L-ornithine transaminase (OTAse) genetic 1 1 1 Phenotypic Suppression
ALK2 YBL009W Atypical protein kinase genetic 1 1 1 Negative Genetic