Standard name Systematic name Name description Description
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
Visualize the interactome of LYS20
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.268 0.107 0.111
Mito 0.161 0.107 0.205
Nucleus 0.889 0.857 0.884
Nucleolus NaN 0.161 0.143

GFP localization & abundance

GFP localization GFP abundance
nucleus 28100

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
LYS20 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_1838 (homocitrate synthase), r_0543 (homocitrate synthase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 5 2 3 Dosage Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue, Phenotypic Suppression
LYS21 YDL131W Homocitrate synthase isozyme genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
LYS21 YDL131W Homocitrate synthase isozyme physical 3 2 3 Affinity Capture-MS, PCA, PCA
GCN2 YDR283C Protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SHM1 YBR263W Mitochondrial serine hydroxymethyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
COX5A YNL052W Subunit Va of cytochrome c oxidase genetic 2 1 2 Negative Genetic, Negative Genetic
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
HSP82 YPL240C Hsp90 chaperone physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CTR1 YPR124W High-affinity copper transporter of plasma membrane genetic 2 1 2 Negative Genetic, Negative Genetic
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair physical 2 1 2 PCA, PCA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 2 1 2 Negative Genetic, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 1 2 Negative Genetic, Negative Genetic
THR4 YCR053W Threonine synthase genetic 2 1 2 Negative Genetic, Negative Genetic
YHM2 YMR241W Citrate and oxoglutarate carrier protein genetic 2 1 2 Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 2 Negative Genetic, Negative Genetic
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 2 1 2 Negative Genetic, Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 2 1 2 Negative Genetic, Negative Genetic
PRB1 YEL060C Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity genetic 2 1 2 Negative Genetic, Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 2 1 2 Negative Genetic, Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 2 Negative Genetic, Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 2 1 2 Negative Genetic, Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 2 1 2 Negative Genetic, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 2 1 Phenotypic Suppression, Dosage Growth Defect
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 2 1 1 Negative Genetic, Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 1 1 1 Biochemical Activity
AEP2 YMR282C Mitochondrial protein genetic 1 1 1 Negative Genetic
HHF2 YNL030W Histone H4 physical 1 1 1 Biochemical Activity
ECM29 YHL030W Scaffold protein physical 1 1 1 Affinity Capture-MS
KGD1 YIL125W Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex genetic 1 1 1 Synthetic Lethality
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit physical 1 1 1 Affinity Capture-MS
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-Western
AHA1 YDR214W Co-chaperone that binds Hsp82p and activates its ATPase activity genetic 1 1 1 Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Affinity Capture-MS
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-Western
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
FUM1 YPL262W Fumarase genetic 1 1 1 Synthetic Lethality
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Positive Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Negative Genetic
BNA5 YLR231C Kynureninase genetic 1 1 1 Synthetic Lethality
ESL1 YIL151C hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
DPH1 YIL103W Protein required for synthesis of diphthamide physical 1 1 1 Affinity Capture-MS
GAP1 YKR039W General amino acid permease genetic 1 1 1 Synthetic Lethality
ARO8 YGL202W Aromatic aminotransferase I genetic 1 1 1 Negative Genetic
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Synthetic Lethality
UBP14 YBR058C Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
YBL086C YBL086C Protein of unknown function physical 1 1 1 Affinity Capture-MS
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
RPL37B YDR500C Ribosomal 60S subunit protein L37B physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-MS
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B physical 1 1 1 Affinity Capture-MS
TFA2 YKR062W TFIIE small subunit physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Negative Genetic
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 Affinity Capture-MS
RPL10 YLR075W Ribosomal 60S subunit protein L10 physical 1 1 1 Affinity Capture-MS
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Affinity Capture-MS
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
YPT7 YML001W Rab family GTPase physical 1 1 1 Affinity Capture-MS
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SDH3 YKL141W Subunit of succinate dehydrogenase and of TIM22 translocase genetic 1 1 1 Synthetic Lethality
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SSY1 YDR160W Component of the SPS plasma membrane amino acid sensor system genetic 1 1 1 Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Dosage Rescue
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Negative Genetic
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
MSC6 YOR354C Multicopy suppressor of HER2 involved in mitochondrial translation genetic 1 1 1 Negative Genetic
RTC6 YPL183W-A Protein involved in translation genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
TPM2 YIL138C Minor isoform of tropomyosin genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
YOL057W YOL057W Dipeptidyl-peptidase III genetic 1 1 1 Negative Genetic
SPO24 YPR036W-A Small (67 amino acids) protein involved in sporulation genetic 1 1 1 Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Dosage Rescue
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Dosage Growth Defect
BNA1 YJR025C 3-hydroxyanthranilic acid dioxygenase genetic 1 1 1 Synthetic Lethality
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Positive Genetic
BNA2 YJR078W Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase genetic 1 1 1 Synthetic Lethality
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
LYP1 YNL268W Lysine permease genetic 1 1 1 Synthetic Lethality
ATG15 YCR068W Phospholipase genetic 1 1 1 Negative Genetic
LSC2 YGR244C Beta subunit of succinyl-CoA ligase genetic 1 1 1 Synthetic Lethality
BNA4 YBL098W Kynurenine 3-monooxygenase genetic 1 1 1 Synthetic Lethality