Standard name Systematic name Name description Description
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication
Visualize the interactome of RNR1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 47

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery NaN NaN 0.25
Cytoplasm NaN NaN 0.65
ER NaN NaN 0.05
Nucleolus NaN NaN 0.05
Nucleus NaN NaN 0.10
Vac/Vac Memb NaN NaN 0.05

GFP localization & abundance

GFP localization GFP abundance
ambiguous 293000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RNR1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0974 (ribonucleotide reductase), r_0979 (ribonucleotide reductase), r_0978 (ribonucleotide reductase), r_0977 (ribonucleotide reductase), r_0975 (ribonucleotide reductase), r_0976 (ribonucleotide reductase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SML1 YML058W Ribonucleotide reductase inhibitor physical 6 3 5 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 5 4 5 Phenotypic Suppression, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 5 3 5 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 5 4 3 Dosage Lethality, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue
FKH2 YNL068C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
RAD53 YPL153C DNA damage response kinase genetic 4 2 4 Dosage Rescue, Dosage Rescue, Dosage Growth Defect, Dosage Rescue
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 4 1 4 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 4 2 3 Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit physical 3 3 3 Affinity Capture-MS, Co-crystal Structure, FRET
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase genetic 3 2 3 Dosage Rescue, Synthetic Growth Defect, Synthetic Growth Defect
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase physical 3 2 3 Two-hybrid, Co-fractionation, Co-fractionation
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 3 3 1 beta-galactosidase reporter gene assay evidence, qualitative western immunoblotting evidence, quantitative reverse transcription polymerase chain reaction evidence
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 3 3 1 beta-galactosidase reporter gene assay evidence, qualitative western immunoblotting evidence, quantitative reverse transcription polymerase chain reaction evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 2 2 2 chromatin immunoprecipitation-chip evidence, quantitative reverse transcription polymerase chain reaction evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 2 2 2 chromatin immunoprecipitation-chip evidence, S1 nuclease protection assay evidence
SWI6 YLR182W Transcription cofactor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, S1 nuclease protection assay evidence
MBP1 YDL056W Transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
MSH2 YOL090W Protein that binds to DNA mismatches genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
DBP8 YHR169W ATPase, putative RNA helicase of the DEAD-box family physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 2 2 1 Phenotypic Suppression, Dosage Rescue
SML1 YML058W Ribonucleotide reductase inhibitor genetic 2 2 1 Synthetic Rescue, Synthetic Lethality
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones physical 2 2 1 Reconstituted Complex, Two-hybrid
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 2 2 1 Synthetic Lethality, Phenotypic Enhancement
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MET7 YOR241W Folylpolyglutamate synthetase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ARG2 YJL071W Acetylglutamate synthase (glutamate N-acetyltransferase) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 DNA to cDNA expression microarray evidence
SRL3 YKR091W Repressor of transcription at Start regulation 1 1 1 chromatin immunoprecipitation-qPCR evidence
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Dosage Rescue
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Lethality
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
BNI1 YNL271C Formin physical 1 1 1 Reconstituted Complex
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Synthetic Lethality
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Dosage Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
ACS2 YLR153C Acetyl-coA synthetase isoform physical 1 1 1 Affinity Capture-MS
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Suppression
FAA2 YER015W Medium chain fatty acyl-CoA synthetase physical 1 1 1 Two-hybrid
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Affinity Capture-MS
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit physical 1 1 1 Co-crystal Structure
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Dosage Rescue
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase physical 1 1 1 Protein-peptide
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 PCA
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Growth Defect
RRP12 YPL012W Protein required for export of the ribosomal subunits genetic 1 1 1 Synthetic Rescue
THR1 YHR025W Homoserine kinase genetic 1 1 1 Dosage Rescue
TRM9 YML014W tRNA methyltransferase genetic 1 1 1 Phenotypic Suppression
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Synthetic Rescue
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Rescue
RNH203 YLR154C Ribonuclease H2 subunit genetic 1 1 1 Synthetic Lethality
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase physical 1 1 1 Affinity Capture-MS
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Synthetic Lethality
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Synthetic Lethality
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Dosage Rescue
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Synthetic Rescue
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Synthetic Lethality
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Dosage Rescue
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Dosage Rescue
MET7 YOR241W Folylpolyglutamate synthetase physical 1 1 1 Affinity Capture-Western
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-RNA
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Dosage Rescue