Standard name Systematic name Name description Description
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication
Visualize the interactome of TDH2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 1.0 0.978 0.992

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 121000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TDH2 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0486 (glyceraldehyde-3-phosphate dehydrogenase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 genetic 11 3 8 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 3 3 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
HSP82 YPL240C Hsp90 chaperone physical 3 2 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
TDH1 YJL052W Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1 genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
SPE3 YPR069C Spermidine synthase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HYR1 YIR037W Glutathione peroxidase physical 3 3 2 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RAS2 YNL098C GTP-binding protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSC1 YML128C Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 3 3 1 Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 3 3 1 Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
RPN10 YHR200W Proteasome polyubiquitin receptor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YML053C YML053C Putative protein of unknown function physical 2 1 2 Two-hybrid, Two-hybrid
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
RSF2 YJR127C Zinc-finger protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
ADA2 YDR448W Transcription coactivator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
WTM1 YOR230W Transcriptional modulator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
RMP1 YLR145W Subunit of RNase MRP physical 1 1 1 Affinity Capture-RNA
MES1 YGR264C Methionyl-tRNA synthetase physical 1 1 1 Affinity Capture-RNA
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ADA2 YDR448W Transcription coactivator physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 1 1 1 Affinity Capture-MS
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis physical 1 1 1 Affinity Capture-MS
RAD51 YER095W Strand exchange protein physical 1 1 1 Affinity Capture-MS
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes physical 1 1 1 Affinity Capture-MS
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Affinity Capture-MS
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 1 1 1 Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
ACO1 YLR304C Aconitase physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 1 1 1 Affinity Capture-MS
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins physical 1 1 1 PCA
GID7 YCL039W Subunit of GID Complex that binds directly to central component Vid30p physical 1 1 1 Affinity Capture-MS
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism physical 1 1 1 Affinity Capture-MS
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-MS
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) physical 1 1 1 Affinity Capture-MS
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p physical 1 1 1 Affinity Capture-MS
LSC1 YOR142W Alpha subunit of succinyl-CoA ligase genetic 1 1 1 Negative Genetic
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Two-hybrid
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Lethality
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance physical 1 1 1 Affinity Capture-MS
YEL023C YEL023C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
VPS71 YML041C Nucleosome-binding component of the SWR1 complex physical 1 1 1 Affinity Capture-MS
TRM732 YMR259C Protein involved in 2'-O-methylation of C32 of substrate tRNAs physical 1 1 1 Affinity Capture-MS
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex physical 1 1 1 Affinity Capture-MS
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation physical 1 1 1 Affinity Capture-MS
UFD4 YKL010C Ubiquitin-protein ligase (E3) physical 1 1 1 Affinity Capture-MS
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
YIG1 YPL201C Protein that interacts with glycerol 3-phosphatase physical 1 1 1 Affinity Capture-MS
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 PCA
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
VID30 YGL227W Central component of GID Complex, involved in FBPase degradation physical 1 1 1 Affinity Capture-MS
VID24 YBR105C GID Complex regulatory subunit physical 1 1 1 Affinity Capture-MS
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 1 1 1 Affinity Capture-Western
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase genetic 1 1 1 Negative Genetic
UGA1 YGR019W Gamma-aminobutyrate (GABA) transaminase genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
TRS130 YMR218C Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
TSR2 YLR435W Protein with a potential role in pre-rRNA processing genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
NYV1 YLR093C v-SNARE component of the vacuolar SNARE complex physical 1 1 1 Affinity Capture-MS
RAD17 YOR368W Checkpoint protein physical 1 1 1 Affinity Capture-MS
KAR2 YJL034W ATPase involved in protein import into the ER physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CCP1 YKR066C Mitochondrial cytochrome-c peroxidase physical 1 1 1 Affinity Capture-MS
MTF2 YDL044C Mitochondrial protein that interacts with mitochondrial RNA polymerase physical 1 1 1 Proximity Label-MS
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
ACF2 YLR144C Intracellular beta-1,3-endoglucanase physical 1 1 1 Affinity Capture-MS
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) physical 1 1 1 Affinity Capture-MS
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane physical 1 1 1 Affinity Capture-MS
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly physical 1 1 1 Affinity Capture-MS
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
FAT1 YBR041W Very long chain fatty acyl-CoA synthetase and fatty acid transporter physical 1 1 1 Co-fractionation
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex physical 1 1 1 Affinity Capture-MS
TDH1 YJL052W Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1 physical 1 1 1 Affinity Capture-MS
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-MS
AHC2 YCR082W Component of the ADA histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Negative Genetic
GEM1 YAL048C Outer mitochondrial membrane GTPase, subunit of the ERMES complex physical 1 1 1 Affinity Capture-MS
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Synthetic Rescue
OSH7 YHR001W Oxysterol-binding phosphatidylserine transferase genetic 1 1 1 Negative Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
MIC60 YKR016W Component of the MICOS complex physical 1 1 1 Affinity Capture-MS
ECM9 YKR004C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-RNA
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
HST2 YPL015C Cytoplasmic NAD(+)-dependent protein deacetylase genetic 1 1 1 Phenotypic Suppression
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic