Standard name Systematic name Name description Description
CHC1 YGL206C Clathrin heavy chain Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function
Visualize the interactome of CHC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
ER 0.060 0.076 NaN
Golgi 0.866 0.713 0.645
Mito 0.221 0.298 0.590
Nucleolus 0.101 0.088 0.094
Cort. Patches NaN 0.135 0.164
Vac/Vac Memb NaN 0.053 NaN

GFP localization & abundance

GFP localization GFP abundance
late Golgi 28700

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CHC1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CLC1 YGR167W Clathrin light chain physical 13 4 11 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly physical 4 3 4 Affinity Capture-Western, Affinity Capture-Western, Co-localization, Reconstituted Complex
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 4 1 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SLA1 YBL007C Cytoskeletal protein binding protein physical 4 3 3 PCA, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
CLC1 YGR167W Clathrin light chain genetic 4 1 3 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue
SCD5 YOR329C Protein required for normal actin organization and endocytosis genetic 4 3 2 Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Synthetic Lethality
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis physical 3 3 3 Two-hybrid, Co-localization, PCA
SWA2 YDR320C Auxilin-like protein involved in vesicular transport physical 3 3 3 Affinity Capture-Western, Reconstituted Complex, PCA
INP53 YOR109W Polyphosphatidylinositol phosphatase physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
ENT5 YDR153C Protein containing an N-terminal epsin-like domain physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 3 2 3 Affinity Capture-RNA, Affinity Capture-MS, Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 2 2 2 Proximity Label-MS, Affinity Capture-MS
GGA1 YDR358W Golgi-localized protein with homology to gamma-adaptin physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
ENT2 YLR206W Epsin-like protein required for endocytosis and actin patch assembly physical 2 2 2 Affinity Capture-Western, Co-localization
ENT3 YJR125C Protein containing an N-terminal epsin-like domain physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
YAP1801 YHR161C Protein of the AP180 family, involved in clathrin cage assembly physical 2 2 2 Co-localization, Reconstituted Complex
YAP1802 YGR241C Protein of the AP180 family, involved in clathrin cage assembly physical 2 2 2 Co-localization, Reconstituted Complex
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 2 2 2 Synthetic Rescue, Synthetic Lethality
APL4 YPR029C Gamma-adaptin physical 2 2 2 Affinity Capture-Western, PCA
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
LYS12 YIL094C Homo-isocitrate dehydrogenase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
APM1 YPL259C Mu1-like medium subunit of the AP-1 complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
ARF1 YDL192W ADP-ribosylation factor genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
APS1 YLR170C Small subunit of the clathrin-associated adaptor complex AP-1 genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting physical 2 2 1 Co-localization, Two-hybrid
LAA1 YJL207C AP-1 accessory protein genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Dosage Rescue
ARC18 YLR370C Subunit of the ARP2/3 complex physical 1 1 1 PCA
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Dosage Rescue
BNI1 YNL271C Formin physical 1 1 1 PCA
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
SSE2 YBR169C Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family physical 1 1 1 Affinity Capture-MS
GGA1 YDR358W Golgi-localized protein with homology to gamma-adaptin genetic 1 1 1 Synthetic Growth Defect
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Synthetic Lethality
ENT2 YLR206W Epsin-like protein required for endocytosis and actin patch assembly genetic 1 1 1 Dosage Rescue
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Synthetic Growth Defect
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
STE2 YFL026W Receptor for alpha-factor pheromone physical 1 1 1 Co-localization
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases physical 1 1 1 PCA
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases genetic 1 1 1 Phenotypic Enhancement
SSA4 YER103W Heat shock protein that is highly induced upon stress physical 1 1 1 Affinity Capture-MS
INP52 YNL106C Polyphosphatidylinositol phosphatase physical 1 1 1 Affinity Capture-Western
CHS5 YLR330W Component of the exomer complex physical 1 1 1 Affinity Capture-Western
INO1 YJL153C Inositol-3-phosphate synthase physical 1 1 1 PCA
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 PCA
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 PCA
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 PCA
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
PAM1 YDR251W Essential protein of unknown function physical 1 1 1 Affinity Capture-MS
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
ECM29 YHL030W Scaffold protein physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-MS
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
UBX3 YDL091C Clathrin-coated vesicle component, regulator of endocytosis physical 1 1 1 Reconstituted Complex
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-Western
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Dosage Growth Defect
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
MYG1 YER156C Protein involved in mitochondrial function physical 1 1 1 Proximity Label-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Synthetic Lethality
SNC1 YAL030W Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Synthetic Lethality
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Synthetic Lethality
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Synthetic Growth Defect
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Growth Defect
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Synthetic Growth Defect
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Growth Defect
UBI4 YLL039C Ubiquitin genetic 1 1 1 Dosage Rescue
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Phenotypic Enhancement
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex genetic 1 1 1 Phenotypic Enhancement
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Phenotypic Enhancement
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Synthetic Growth Defect
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Synthetic Growth Defect
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Synthetic Growth Defect
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Positive Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
ROM1 YGR070W Guanine nucleotide exchange factor (GEF) for Rho1p genetic 1 1 1 Phenotypic Suppression
IRC6 YFR043C Clathrin coat accessory factor genetic 1 1 1 Synthetic Growth Defect
SEC4 YFL005W Rab family GTPase genetic 1 1 1 Phenotypic Suppression
MPS3 YJL019W Nuclear envelope protein genetic 1 1 1 Synthetic Rescue
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Synthetic Growth Defect
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Synthetic Lethality
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 1 1 1 Affinity Capture-MS
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 Co-localization
APL4 YPR029C Gamma-adaptin genetic 1 1 1 Synthetic Growth Defect
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Affinity Capture-Western
ATG23 YLR431C Peripheral membrane protein required for autophagy and CVT physical 1 1 1 Affinity Capture-MS
ATG8 YBL078C Ub-like protein physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BUD6 YLR319C Actin- and formin-interacting protein physical 1 1 1 PCA
ALY1 YKR021W Alpha arrestin, substrate of calcineurin physical 1 1 1 Affinity Capture-Western
APS1 YLR170C Small subunit of the clathrin-associated adaptor complex AP-1 physical 1 1 1 Affinity Capture-Western
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector physical 1 1 1 PCA
APS2 YJR058C Small subunit of the clathrin-associated adaptor complex AP-2 genetic 1 1 1 Synthetic Growth Defect
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Synthetic Lethality