Standard name Systematic name Name description Description
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
Visualize the interactome of EST2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
EST2 4 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD52 YML032C Protein involved in homologous recombination genetic 8 3 8 Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 7 2 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 7 4 6 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 7 4 6 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 6 4 5 Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
EST3 YIL009C-A Component of the telomerase holoenzyme physical 6 2 4 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 5 4 4 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 5 4 4 Phenotypic Enhancement, Phenotypic Enhancement, Dosage Growth Defect, Synthetic Rescue, Phenotypic Suppression
STN1 YDR082W Telomere end-binding and capping protein genetic 5 3 3 Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 4 2 4 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement
EST3 YIL009C-A Component of the telomerase holoenzyme genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RAD24 YER173W Checkpoint protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 2 2 2 Dosage Rescue, Synthetic Growth Defect
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
CIK1 YMR198W Kinesin-associated protein genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase genetic 2 2 1 Phenotypic Enhancement, Synthetic Growth Defect
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
SCH9 YHR205W AGC family protein kinase genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Phenotypic Enhancement
BEM1 YBR200W Protein containing SH3-domains physical 1 1 1 Two-hybrid
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Phenotypic Enhancement
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Phenotypic Enhancement
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Phenotypic Enhancement
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Phenotypic Enhancement
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Phenotypic Enhancement
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Phenotypic Enhancement
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Synthetic Growth Defect
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Co-localization
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
PXR1 YGR280C Essential protein involved in rRNA and snoRNA maturation physical 1 1 1 Affinity Capture-Western
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-Western
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-Western
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-Western
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-Western
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) physical 1 1 1 Affinity Capture-Western
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) physical 1 1 1 Affinity Capture-Western
SME1 YOR159C Core Sm protein Sm E physical 1 1 1 Affinity Capture-Western
POP6 YGR030C Subunit of RNase MRP, nuclear RNase P and telomerase physical 1 1 1 Affinity Capture-Western
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes physical 1 1 1 Affinity Capture-Western
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-RNA
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Synthetic Lethality
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Lethality
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Phenotypic Enhancement
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Synthetic Rescue
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Phenotypic Enhancement
TEN1 YLR010C Protein that regulates telomeric length genetic 1 1 1 Synthetic Lethality
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Phenotypic Enhancement
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Rescue
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Dosage Rescue
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Phenotypic Suppression
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Phenotypic Enhancement
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Phenotypic Enhancement
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Phenotypic Enhancement
RGI1 YER067W Protein involved in energy metabolism under respiratory conditions genetic 1 1 1 Phenotypic Enhancement
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Phenotypic Enhancement
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Phenotypic Enhancement
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Phenotypic Enhancement
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Phenotypic Enhancement
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Phenotypic Enhancement
VMA22 YHR060W Protein that is required for vacuolar H+-ATPase (V-ATPase) function genetic 1 1 1 Phenotypic Enhancement
YLR358C YLR358C Protein of unknown function genetic 1 1 1 Phenotypic Enhancement
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Growth Defect
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Dosage Growth Defect