Standard name Systematic name Name description Description
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication
Visualize the interactome of MPS2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1 230

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm NaN 0.436 0.637
Endosome NaN 0.143 NaN
Mito NaN 0.060 0.137
SpindlePole NaN 0.353 0.194
Budneck NaN NaN 0.056

GFP localization & abundance

GFP localization GFP abundance
spindle pole no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MPS2 0 5 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
BBP1 YPL255W Protein required for the spindle pole body (SPB) duplication physical 13 5 7 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, FRET, FRET, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-purification, Two-hybrid
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex physical 11 4 6 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Co-purification, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes physical 5 1 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
MPS3 YJL019W Nuclear envelope protein physical 4 2 3 Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NBP1 YLR457C Spindle pole body (SPB) component physical 3 3 1 Two-hybrid, Affinity Capture-Western, Co-localization
MPS3 YJL019W Nuclear envelope protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
NNF1 YJR112W Essential component of the outer kinetochore MIND complex physical 2 1 2 Two-hybrid, Two-hybrid
SMY2 YBR172C GYF domain protein genetic 2 1 2 Dosage Rescue, Dosage Rescue
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs physical 2 2 1 Reconstituted Complex, FRET
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 2 2 1 Two-hybrid, Affinity Capture-Western
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Negative Genetic, Positive Genetic
CUE1 YMR264W Ubiquitin-binding protein genetic 2 2 1 Dosage Rescue, Synthetic Rescue
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
BLI1 YKL061W Subunit of the BLOC-1 complex involved in endosomal maturation physical 2 1 1 Two-hybrid, Two-hybrid
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Dosage Lethality, Dosage Lethality
BBP1 YPL255W Protein required for the spindle pole body (SPB) duplication genetic 2 1 1 Dosage Rescue, Dosage Rescue
CSM4 YPL200W Protein required for accurate chromosome segregation during meiosis physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
LAM4 YHR080C Sterol-binding protein that localizes to puncta in the cortical ER physical 2 1 1 Two-hybrid, Two-hybrid
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BDF1 YLR399C BET family transcriptional regulator physical 1 1 1 Two-hybrid
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Synthetic Lethality
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 1 1 1 Two-hybrid
DYN1 YKR054C Cytoplasmic heavy chain dynein physical 1 1 1 Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Synthetic Lethality
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Two-hybrid
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope physical 1 1 1 Two-hybrid
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization physical 1 1 1 Two-hybrid
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
KRE6 YPR159W Glucosyl hydrolase required for beta-1,6-glucan biosynthesis genetic 1 1 1 Synthetic Lethality
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members physical 1 1 1 Two-hybrid
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Synthetic Lethality
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation physical 1 1 1 Two-hybrid
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Lethality
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Lethality
ASM4 YDL088C FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane physical 1 1 1 Two-hybrid
ADY3 YDL239C Protein required for spore wall formation physical 1 1 1 Two-hybrid
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Synthetic Lethality
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes genetic 1 1 1 Synthetic Lethality
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint physical 1 1 1 Two-hybrid
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Co-purification
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
NBP1 YLR457C Spindle pole body (SPB) component genetic 1 1 1 Dosage Rescue
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes physical 1 1 1 Two-hybrid
VHR1 YIL056W Transcriptional activator physical 1 1 1 Two-hybrid
STE24 YJR117W Highly conserved zinc metalloprotease physical 1 1 1 PCA
RET2 YFR051C Delta subunit of the coatomer complex (COPI) physical 1 1 1 Affinity Capture-Western
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation physical 1 1 1 Two-hybrid
REC107 YJR021C Protein involved in early stages of meiotic recombination physical 1 1 1 Two-hybrid
SRN2 YLR119W Component of the ESCRT-I complex physical 1 1 1 Two-hybrid
STB2 YMR053C Protein that interacts with Sin3p in a two-hybrid assay physical 1 1 1 Two-hybrid
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Two-hybrid
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family physical 1 1 1 Two-hybrid
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) physical 1 1 1 Two-hybrid
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Two-hybrid
TOP1 YOL006C Topoisomerase I physical 1 1 1 Two-hybrid
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif physical 1 1 1 Two-hybrid
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex physical 1 1 1 Affinity Capture-MS
SPC42 YKL042W Central plaque component of spindle pole body (SPB) physical 1 1 1 Affinity Capture-MS
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex physical 1 1 1 Two-hybrid
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions physical 1 1 1 Two-hybrid
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 1 1 1 Two-hybrid
RDR1 YOR380W Transcriptional repressor involved in regulating multidrug resistance physical 1 1 1 Two-hybrid
UBA1 YKL210W Ubiquitin activating enzyme (E1) physical 1 1 1 Two-hybrid
SSY5 YJL156C Serine protease of SPS plasma membrane amino acid sensor system physical 1 1 1 Two-hybrid
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase physical 1 1 1 Two-hybrid
SMC1 YFL008W Subunit of the multiprotein cohesin complex physical 1 1 1 Two-hybrid
VAC14 YLR386W Enzyme regulator physical 1 1 1 Two-hybrid
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 1 1 1 Two-hybrid
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes physical 1 1 1 Two-hybrid
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 1 1 1 Synthetic Rescue
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Synthetic Rescue
NDC1 YML031W Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Dosage Rescue
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication genetic 1 1 1 Dosage Rescue
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway genetic 1 1 1 Synthetic Lethality
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Rescue
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Synthetic Rescue
SPO7 YAL009W Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Synthetic Growth Defect
RTN1 YDR233C Reticulon protein genetic 1 1 1 Phenotypic Suppression
YOP1 YPR028W Reticulon-interacting protein genetic 1 1 1 Phenotypic Suppression
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Synthetic Rescue
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Synthetic Growth Defect
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
POM33 YLL023C Transmembrane nucleoporin genetic 1 1 1 Synthetic Lethality
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Lethality
HAP4 YKL109W Transcription factor physical 1 1 1 Two-hybrid
EUC1 YMR111C Sequence-specific DNA binding protein physical 1 1 1 Two-hybrid
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP physical 1 1 1 Two-hybrid
HSK3 YKL138C-A Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 Two-hybrid
ICS2 YBR157C Protein of unknown function physical 1 1 1 Two-hybrid
ECM13 YBL043W Non-essential protein of unknown function physical 1 1 1 Two-hybrid
FLO9 YAL063C Lectin-like protein with similarity to Flo1p physical 1 1 1 Two-hybrid