| SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
physical |
13 |
5 |
12 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex |
| SEC10 |
YLR166C |
Essential 100kDa subunit of the exocyst complex |
physical |
13 |
4 |
8 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex |
| SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
10 |
5 |
8 |
Dosage Rescue, Dosage Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Dosage Growth Defect, Dosage Rescue, Negative Genetic, Dosage Rescue |
| SEC9 |
YGR009C |
t-SNARE protein required for secretory vesicle-plasma membrane fusion |
genetic |
8 |
5 |
7 |
Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Lethality, Negative Genetic, Synthetic Growth Defect |
| SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
physical |
8 |
4 |
7 |
Co-fractionation, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization |
| SEC4 |
YFL005W |
Rab family GTPase |
physical |
8 |
4 |
6 |
Affinity Capture-Western, Two-hybrid, Co-fractionation, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
| SEC4 |
YFL005W |
Rab family GTPase |
genetic |
8 |
3 |
6 |
Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue, Dosage Rescue |
| EXO84 |
YBR102C |
Exocyst subunit with dual roles in exocytosis and spliceosome assembly |
physical |
7 |
4 |
6 |
Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
6 |
4 |
6 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic |
| SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
genetic |
6 |
4 |
5 |
Synthetic Lethality, Synthetic Lethality, Dosage Lethality, Dosage Rescue, Negative Genetic, Dosage Rescue |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic |
| EXO70 |
YJL085W |
Subunit of the exocyst complex |
physical |
6 |
3 |
5 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
physical |
6 |
2 |
5 |
Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
physical |
6 |
4 |
3 |
Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification |
| EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
6 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
physical |
5 |
3 |
5 |
Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
| MSO1 |
YNR049C |
Lipid-interacting protein in SNARE complex assembly machinery |
genetic |
5 |
3 |
5 |
Synthetic Growth Defect, Dosage Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| SEC3 |
YER008C |
Subunit of the exocyst complex |
genetic |
5 |
4 |
3 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Dosage Growth Defect, Negative Genetic |
| SEC10 |
YLR166C |
Essential 100kDa subunit of the exocyst complex |
genetic |
5 |
3 |
3 |
Dosage Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
physical |
5 |
4 |
1 |
Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, PCA, Co-localization |
| SEC3 |
YER008C |
Subunit of the exocyst complex |
physical |
4 |
3 |
3 |
Affinity Capture-MS, Co-localization, Affinity Capture-Western, Affinity Capture-MS |
| MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
genetic |
4 |
3 |
3 |
Dosage Rescue, Synthetic Lethality, Dosage Rescue, Negative Genetic |
| RHO3 |
YIL118W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue |
| NBP2 |
YDR162C |
Protein involved in the HOG (high osmolarity glycerol) pathway |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
3 |
3 |
3 |
Dosage Rescue, Negative Genetic, Synthetic Lethality |
| BOI2 |
YER114C |
Protein involved in polar growth |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Dosage Rescue |
| DSS4 |
YPR017C |
Guanine nucleotide dissociation stimulator for Sec4p |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| SSO2 |
YMR183C |
Plasma membrane t-SNARE |
genetic |
3 |
2 |
3 |
Dosage Rescue, Negative Genetic, Negative Genetic |
| CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| EXO84 |
YBR102C |
Exocyst subunit with dual roles in exocytosis and spliceosome assembly |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| SBH1 |
YER087C-B |
Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
3 |
2 |
2 |
Dosage Rescue, Phenotypic Enhancement, Dosage Rescue |
| YPT1 |
YFL038C |
Rab family GTPase |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| PFY1 |
YOR122C |
Profilin |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
genetic |
3 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality |
| SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SSO1 |
YPL232W |
Plasma membrane t-SNARE |
genetic |
2 |
2 |
2 |
Dosage Rescue, Negative Genetic |
| ERG7 |
YHR072W |
Lanosterol synthase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| AGE2 |
YIL044C |
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
| PIK1 |
YNL267W |
Phosphatidylinositol 4-kinase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| KIN3 |
YAR018C |
Nonessential serine/threonine protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MRPL1 |
YDR116C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OPI1 |
YHL020C |
Transcriptional regulator of a variety of genes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| KIN2 |
YLR096W |
S/T protein kinase |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
| UBP9 |
YER098W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| STT4 |
YLR305C |
Phosphatidylinositol-4-kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SWD1 |
YAR003W |
Subunit of the COMPASS (Set1C) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SYT1 |
YPR095C |
Guanine nucleotide exchange factor (GEF) for Arf proteins |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
physical |
2 |
2 |
1 |
PCA, Reconstituted Complex |
| SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
2 |
2 |
1 |
Dosage Rescue, Synthetic Rescue |
| PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Dosage Lethality |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| BET2 |
YPR176C |
Beta subunit of Type II geranylgeranyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| GDI1 |
YER136W |
GDP dissociation inhibitor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CMD1 |
YBR109C |
Calmodulin |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
| MRS6 |
YOR370C |
Rab escort protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ERG6 |
YML008C |
Delta(24)-sterol C-methyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| FRQ1 |
YDR373W |
N-myristoylated calcium-binding protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SRB5 |
YGR104C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK16 |
YAL025C |
Essential nuclear protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NIP7 |
YPL211W |
Nucleolar protein required for 60S ribosome subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPF1 |
YHR088W |
Protein involved in assembly and export of the large ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IPI1 |
YHR085W |
Component of the Rix1 complex and possibly pre-replicative complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| EMW1 |
YNL313C |
Essential conserved protein with a role in cell wall integrity |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOC2 |
YOR206W |
Protein involved in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ARL1 |
YBR164C |
Soluble GTPase with a role in regulation of membrane traffic |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRT4 |
YKL009W |
Protein involved in mRNA turnover and ribosome assembly |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NOP15 |
YNL110C |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| NOP56 |
YLR197W |
Essential evolutionarily-conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPC40 |
YPR110C |
RNA polymerase subunit AC40 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ARP7 |
YPR034W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RSC9 |
YML127W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HCR1 |
YLR192C |
eIF3j component of translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPE1 |
YKL059C |
Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ECM16 |
YMR128W |
Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APL2 |
YKL135C |
Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BMH2 |
YDR099W |
14-3-3 protein, minor isoform |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOI2 |
YER114C |
Protein involved in polar growth |
physical |
1 |
1 |
1 |
PCA |
| CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
physical |
1 |
1 |
1 |
Two-hybrid |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| BNI1 |
YNL271C |
Formin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| COP1 |
YDL145C |
Alpha subunit of COPI vesicle coatomer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG13 |
YML126C |
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTO1 |
YCR015C |
Protein required for cold tolerance |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HRP1 |
YOL123W |
Subunit of cleavage factor I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRT1 |
YOL133W |
RING-H2 domain core subunit of multiple ubiquitin ligase complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APM1 |
YPL259C |
Mu1-like medium subunit of the AP-1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
1 |
1 |
1 |
Two-hybrid |
| NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PDC1 |
YLR044C |
Major of three pyruvate decarboxylase isozymes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MKT1 |
YNL085W |
Protein similar to nucleases that forms a complex with Pbp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAM1 |
YDL090C |
Beta subunit of the CAAX farnesyltransferase (FTase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC11 |
YDR045C |
RNA polymerase III subunit C11 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPC53 |
YDL150W |
RNA polymerase III subunit C53 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPP2B |
YDR382W |
Ribosomal protein P2 beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RXT3 |
YDL076C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EFB1 |
YAL003W |
Translation elongation factor 1 beta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| BET5 |
YML077W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAB5 |
YDR196C |
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GET4 |
YOR164C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FIN1 |
YDR130C |
Spindle pole body-related intermediate filament protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KIN1 |
YDR122W |
S/T protein kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| GET2 |
YER083C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG27 |
YLR100W |
3-keto sterol reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IPA1 |
YJR141W |
Protein implicated in pre-mRNA processing and proteasomal degradation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GLE1 |
YDL207W |
Cytoplasmic nucleoporin required for polyadenylated mRNA export |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ELC1 |
YPL046C |
Elongin C, conserved among eukaryotes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM8 |
YJR022W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GBP2 |
YCL011C |
Poly(A+) RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HOM2 |
YDR158W |
Aspartic beta semi-aldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APL4 |
YPR029C |
Gamma-adaptin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG13 |
YPR185W |
Regulatory subunit of the Atg1p signaling complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GDS1 |
YOR355W |
Protein involved in histone H4 acetylation at ribosomal protein genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LST7 |
YGR057C |
Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NBA1 |
YOL070C |
Protein involved in axial bud site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SBH2 |
YER019C-A |
Ssh1p-Sss1p-Sbh2p complex component |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| IRC6 |
YFR043C |
Clathrin coat accessory factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASK10 |
YGR097W |
Regulator of the Fps1p glycerol channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BOS1 |
YLR078C |
v-SNARE (vesicle specific SNAP receptor) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELO2 |
YCR034W |
Fatty acid elongase, involved in sphingolipid biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| OST2 |
YOR103C |
Epsilon subunit of the oligosaccharyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SBH1 |
YER087C-B |
Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| VPS54 |
YDR027C |
Component of the GARP (Golgi-associated retrograde protein) complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| SNX3 |
YOR357C |
Sorting nexin for late-Golgi enzymes |
physical |
1 |
1 |
1 |
Two-hybrid |
| SNX4 |
YJL036W |
Sorting nexin |
physical |
1 |
1 |
1 |
Two-hybrid |
| SSA2 |
YLL024C |
HSP70 family ATP-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SEC22 |
YLR268W |
R-SNARE protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SSO2 |
YMR183C |
Plasma membrane t-SNARE |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SSS1 |
YDR086C |
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ZUO1 |
YGR285C |
Ribosome-associated chaperone |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SIF2 |
YBR103W |
WD40 repeat-containing subunit of Set3C histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SFH5 |
YJL145W |
Unusual phosphatidylinositol transfer protein (PITP) that binds heme |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SEN54 |
YPL083C |
Subunit of the tRNA splicing endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SSU72 |
YNL222W |
Phosphatase and transcription/RNA-processing factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TAH18 |
YPR048W |
Conserved NAPDH-dependent diflavin reductase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TFB1 |
YDR311W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| UTP4 |
YDR324C |
Subunit of U3-containing 90S preribosome and SSU processome complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SRB6 |
YBR253W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SWP1 |
YMR149W |
Delta subunit of the oligosaccharyl transferase glycoprotein complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TAF10 |
YDR167W |
Subunit (145 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TOR2 |
YKL203C |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UTP9 |
YHR196W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YPP1 |
YGR198W |
Cargo-transport protein involved in endocytosis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ZPR1 |
YGR211W |
Essential protein with two zinc fingers |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YNL046W |
YNL046W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| WBP1 |
YEL002C |
Beta subunit of the oligosaccharyl transferase glycoprotein complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRS20 |
YBR254C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMC4 |
YLR086W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBL081W |
YBL081W |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SFA1 |
YDL168W |
Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOM71 |
YHR117W |
Mitochondrial outer membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUL2 |
YLR092W |
High affinity sulfate permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLR287C |
YLR287C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YML108W |
YML108W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPM1 |
YNL079C |
Major isoform of tropomyosin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPO7 |
YAL009W |
Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA9 |
YCL005W-A |
Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWA2 |
YDR320C |
Auxilin-like protein involved in vesicular transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAN1 |
YML115C |
Component of the mannan polymerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRS65 |
YGR166W |
Component of transport protein particle (TRAPP) complex II |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SVP26 |
YHR181W |
ER exit adaptor for Golgi mannosyltransferases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSO1 |
YNR049C |
Lipid-interacting protein in SNARE complex assembly machinery |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| GPR1 |
YDL035C |
Plasma membrane G protein coupled receptor (GPCR) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP16 |
YKR086W |
DEAH-box RNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPR2 |
YIR015W |
Subunit of nuclear RNase P |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MSB3 |
YNL293W |
Rab GTPase-activating protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RSR1 |
YGR152C |
Ras-type GTPase |
physical |
1 |
1 |
1 |
Two-hybrid |
| BET4 |
YJL031C |
Alpha subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MON2 |
YNL297C |
Protein with a role in endocytosis and vacuole integrity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTN1 |
YDR233C |
Reticulon protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| AIM44 |
YPL158C |
Regulator of Cdc42p and Rho1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PBN1 |
YCL052C |
Component of glycosylphosphatidylinositol-mannosyltransferase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GEF1 |
YJR040W |
Voltage-gated chloride channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GAT2 |
YMR136W |
Protein containing GATA family zinc finger motifs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAM17 |
YKR065C |
Constituent of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI2 |
YPL076W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ATG32 |
YIL146C |
Mitochondrial outer membrane protein required to initiate mitophagy |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APS1 |
YLR170C |
Small subunit of the clathrin-associated adaptor complex AP-1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC14 |
YMR079W |
Phosphatidylinositol/phosphatidylcholine transfer protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PHB2 |
YGR231C |
Subunit of the prohibitin complex (Phb1p-Phb2p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI17 |
YDR434W |
Transmembrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARV1 |
YLR242C |
Cortical ER protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALG13 |
YGL047W |
Catalytic component of UDP-GlcNAc transferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CHS2 |
YBR038W |
Chitin synthase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALG14 |
YBR070C |
Component of UDP-GlcNAc transferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KRE1 |
YNL322C |
Cell wall glycoprotein involved in beta-glucan assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDS1 |
YBR029C |
Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| AVL9 |
YLR114C |
Conserved protein involved in exocytic transport from the Golgi |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RMD8 |
YFR048W |
Cytosolic protein required for sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI8 |
YDR331W |
Catalytic subunit of the ER membrane GPI transamidase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERD2 |
YBL040C |
HDEL receptor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MSC6 |
YOR354C |
Multicopy suppressor of HER2 involved in mitochondrial translation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHM7 |
YOL084W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PGA1 |
YNL158W |
Essential component of GPI-mannosyltransferase II |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MIN3 |
YMR182W-A |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
