Standard name Systematic name Name description Description
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
Visualize the interactome of HRD1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cort. Patches 0.054 NaN NaN
Cytoplasm 0.789 0.731 0.774
ER 0.130 0.173 NaN
Mito NaN 0.135 0.115

GFP localization & abundance

GFP localization GFP abundance
ER 2660

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HRD1 7 0 0 1 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
UBC7 YMR022W Ubiquitin conjugating enzyme physical 17 3 15 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Reconstituted Complex, Reconstituted Complex
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) physical 15 4 14 Biochemical Activity, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Co-crystal Structure, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
HRD3 YLR207W ER membrane protein that plays a central role in ERAD physical 13 4 11 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Co-crystal Structure, Co-crystal Structure
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 9 3 9 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 9 4 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase physical 9 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 8 3 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
HMG2 YLR450W HMG-CoA reductase physical 8 3 6 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 8 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 7 2 7 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
HRD3 YLR207W ER membrane protein that plays a central role in ERAD genetic 6 3 5 Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
SEC61 YLR378C Conserved ER protein translocation channel genetic 6 3 5 Dosage Lethality, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
YOS9 YDR057W ER quality-control lectin physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides physical 5 2 5 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase genetic 4 2 3 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Dosage Rescue
PDI1 YCL043C Protein disulfide isomerase genetic 4 2 2 Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 4 2 2 Positive Genetic, Positive Genetic, Phenotypic Suppression, Phenotypic Suppression
ILM1 YJR118C Protein of unknown function genetic 4 1 2 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 4 1 2 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
PRC1 YMR297W Vacuolar carboxypeptidase Y (proteinase C, CPY) physical 3 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
UBI4 YLL039C Ubiquitin physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 3 2 2 Phenotypic Suppression, Dosage Rescue, Phenotypic Suppression
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect
IRC23 YOR044W Protein of unknown function involved in multidrug resistance genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
SLP1 YOR154W Glycosylated integral ER membrane protein of unknown function genetic 3 1 2 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 3 1 2 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BIG1 YHR101C Integral membrane protein of the endoplasmic reticulum genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 2 2 2 Reconstituted Complex, Biochemical Activity
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
DFM1 YDR411C Endoplasmic reticulum (ER) localized protein physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 2 1 2 Positive Genetic, Positive Genetic
MSS2 YDL107W Peripherally bound inner membrane protein of the mitochondrial matrix genetic 2 1 2 Negative Genetic, Negative Genetic
PRP4 YPR178W Splicing factor genetic 2 1 2 Negative Genetic, Negative Genetic
PEP4 YPL154C Vacuolar aspartyl protease (proteinase A) genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
ASI3 YNL008C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 2 2 1 Synthetic Lethality, Phenotypic Enhancement
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
UBC1 YDR177W Ubiquitin-conjugating enzyme physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
STE24 YJR117W Highly conserved zinc metalloprotease genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
ASI1 YMR119W Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 2 2 1 Phenotypic Enhancement, Synthetic Lethality
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 2 2 1 Phenotypic Enhancement, Synthetic Growth Defect
ARF1 YDL192W ADP-ribosylation factor genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CUE5 YOR042W Ubiquitin-binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes genetic 2 1 1 Negative Genetic, Negative Genetic
YOS9 YDR057W ER quality-control lectin genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SSE2 YBR169C Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
RSB1 YOR049C Sphingoid long-chain base (LCB) efflux transporter genetic 2 1 1 Negative Genetic, Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 1 Positive Genetic, Positive Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 2 1 1 Positive Genetic, Positive Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PER1 YCR044C Protein of the endoplasmic reticulum genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
LCL2 YLR104W Putative protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ROT2 YBR229C Glucosidase II catalytic subunit genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YPT6 YLR262C Rab family GTPase genetic 2 1 1 Positive Genetic, Positive Genetic
CUE1 YMR264W Ubiquitin-binding protein genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) regulation 1 1 1 ubiquitination assay evidence
UBP1 YDL122W Ubiquitin-specific protease regulation 1 1 1 deubiquitination assay evidence
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Phenotypic Enhancement
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 physical 1 1 1 Affinity Capture-MS
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Positive Genetic
ARO1 YDR127W Pentafunctional arom protein physical 1 1 1 Affinity Capture-MS
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
EMP24 YGL200C Component of the p24 complex genetic 1 1 1 Phenotypic Enhancement
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HIS4 YCL030C Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase physical 1 1 1 Affinity Capture-MS
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
DUG1 YFR044C Cys-Gly metallo-di-peptidase physical 1 1 1 Affinity Capture-MS
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform physical 1 1 1 Affinity Capture-MS
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Synthetic Rescue
CDC60 YPL160W Cytosolic leucyl tRNA synthetase physical 1 1 1 Affinity Capture-MS
CYS3 YAL012W Cystathionine gamma-lyase physical 1 1 1 Affinity Capture-MS
GDH1 YOR375C NADP(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
ERV41 YML067C Protein localized to COPII-coated vesicles genetic 1 1 1 Phenotypic Suppression
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Positive Genetic
THR4 YCR053W Threonine synthase physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
SAC6 YDR129C Fimbrin, actin-bundling protein physical 1 1 1 Affinity Capture-MS
MET6 YER091C Cobalamin-independent methionine synthase physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P physical 1 1 1 Affinity Capture-MS
OYE2 YHR179W Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) physical 1 1 1 Affinity Capture-MS
TDH1 YJL052W Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1 physical 1 1 1 Affinity Capture-MS
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
URA6 YKL024C Uridylate kinase physical 1 1 1 Affinity Capture-MS
TIF1 YKR059W Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
IDP3 YNL009W Peroxisomal NADP-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
SPE3 YPR069C Spermidine synthase physical 1 1 1 Affinity Capture-MS
SPE3 YPR069C Spermidine synthase genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Synthetic Rescue
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Phenotypic Enhancement
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane physical 1 1 1 Affinity Capture-MS
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Phenotypic Enhancement
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Biochemical Activity
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Phenotypic Enhancement
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Dosage Rescue
OLE1 YGL055W Delta(9) fatty acid desaturase physical 1 1 1 Affinity Capture-Western
KAR2 YJL034W ATPase involved in protein import into the ER physical 1 1 1 Affinity Capture-Western
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
OTU1 YFL044C Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p physical 1 1 1 Biochemical Activity
UBP1 YDL122W Ubiquitin-specific protease physical 1 1 1 Affinity Capture-Western
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD physical 1 1 1 Reconstituted Complex
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 1 1 1 Phenotypic Enhancement
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Phenotypic Enhancement
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Phenotypic Enhancement
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 1 1 1 Phenotypic Suppression
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Dosage Lethality
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Phenotypic Enhancement
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Phenotypic Enhancement
RTT106 YNL206C Histone chaperone genetic 1 1 1 Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Synthetic Rescue
SHR5 YOL110W Palmitoyltransferase subunit genetic 1 1 1 Phenotypic Suppression
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Phenotypic Enhancement
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 1 1 1 Phenotypic Enhancement
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
VTC5 YDR089W Novel subunit of the vacuolar transporter chaperone complex genetic 1 1 1 Negative Genetic
PSP1 YDR505C Asn and gln rich protein of unknown function genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YRB30 YGL164C RanGTP-binding protein genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Negative Genetic
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Phenotypic Enhancement
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Synthetic Growth Defect
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Synthetic Rescue
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme genetic 1 1 1 Synthetic Rescue
HYR1 YIR037W Glutathione peroxidase genetic 1 1 1 Synthetic Rescue
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Synthetic Rescue
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Synthetic Rescue
ERV29 YGR284C Protein localized to COPII-coated vesicles genetic 1 1 1 Phenotypic Enhancement
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 physical 1 1 1 Affinity Capture-MS
GLR1 YPL091W Cytosolic and mitochondrial glutathione oxidoreductase genetic 1 1 1 Synthetic Rescue
HMG1 YML075C HMG-CoA reductase physical 1 1 1 Reconstituted Complex
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
GLO4 YOR040W Mitochondrial glyoxalase II genetic 1 1 1 Negative Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Positive Genetic
GCG1 YER163C Gamma-glutamyl cyclotransferase genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Positive Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Positive Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic