| SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
genetic |
5 |
2 |
5 |
Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression |
| DMC1 |
YER179W |
Meiosis-specific recombinase required for double-strand break repair |
genetic |
4 |
4 |
4 |
Dosage Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression |
| IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
physical |
4 |
1 |
4 |
Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity |
| CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Negative Genetic |
| ZIP1 |
YDR285W |
Transverse filament protein of the synaptonemal complex |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| PCH2 |
YBR186W |
Hexameric ring ATPase that remodels chromosome axis protein Hop1p |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
| ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| MND2 |
YIR025W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| CST9 |
YLR394W |
SUMO E3 ligase |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| SMM1 |
YNR015W |
Dihydrouridine synthase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| RAD17 |
YOR368W |
Checkpoint protein |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| LCB4 |
YOR171C |
Sphingoid long-chain base kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
regulation |
2 |
2 |
1 |
northern blot evidence, qualitative western immunoblotting evidence |
| CYC8 |
YBR112C |
General transcriptional co-repressor |
regulation |
2 |
2 |
1 |
northern blot evidence, RNA-sequencing evidence |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
regulation |
2 |
2 |
1 |
northern blot evidence, RNA-sequencing evidence |
| MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
physical |
2 |
2 |
1 |
Two-hybrid, Biochemical Activity |
| RSF2 |
YJR127C |
Zinc-finger protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-qPCR evidence |
| BDF1 |
YLR399C |
BET family transcriptional regulator |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
| CLB4 |
YLR210W |
B-type cyclin involved in cell cycle progression |
regulation |
1 |
1 |
1 |
northern blot evidence |
| CLB3 |
YDL155W |
B-type cyclin involved in cell cycle progression |
regulation |
1 |
1 |
1 |
northern blot evidence |
| CLB1 |
YGR108W |
B-type cyclin involved in cell cycle progression |
regulation |
1 |
1 |
1 |
northern blot evidence |
| CLB6 |
YGR109C |
B-type cyclin involved in DNA replication during S phase |
regulation |
1 |
1 |
1 |
northern blot evidence |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
regulation |
1 |
1 |
1 |
northern blot evidence |
| SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
regulation |
1 |
1 |
1 |
northern blot evidence |
| HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
| IZH4 |
YOL101C |
Membrane protein involved in zinc ion homeostasis |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| SMK1 |
YPR054W |
Middle sporulation-specific mitogen-activated protein kinase (MAPK) |
regulation |
1 |
1 |
1 |
northern blot evidence |
| HSP30 |
YCR021C |
Negative regulator of the H(+)-ATPase Pma1p |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| RTC5 |
YOR118W |
Protein of unknown function |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| YLR162W |
YLR162W |
Protein of unknown function |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| RRT15 |
YLR162W-A |
Putative protein of unknown function |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| DIT1 |
YDR403W |
Sporulation-specific enzyme required for spore wall maturation |
regulation |
1 |
1 |
1 |
northern blot evidence |
| SPS1 |
YDR523C |
STE20-family GCKIII protein kinase |
regulation |
1 |
1 |
1 |
northern blot evidence |
| ADA2 |
YDR448W |
Transcription coactivator |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
| RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
| MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
regulation |
1 |
1 |
1 |
protein kinase assay evidence |
| IME1 |
YJR094C |
Master regulator of meiosis that is active only during meiotic events |
regulation |
1 |
1 |
1 |
northern blot evidence |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARX1 |
YDR101C |
Nuclear export factor for the ribosomal pre-60S subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CFT2 |
YLR115W |
Subunit of the mRNA cleavage and polyadenlylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUS1 |
YMR240C |
Protein required for assembly of U2 snRNP into the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF3 |
YPR023C |
Component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FIP1 |
YJR093C |
Subunit of cleavage polyadenylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HST1 |
YOL068C |
NAD(+)-dependent histone deacetylase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| LAS17 |
YOR181W |
Actin assembly factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| IES5 |
YER092W |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AFG2 |
YLR397C |
ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD21 |
YOR078W |
Component of small ribosomal subunit (SSU) processosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MET18 |
YIL128W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSH4 |
YFL003C |
Protein involved in meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC53 |
YDL132W |
Cullin |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MLH3 |
YPL164C |
Protein involved in DNA mismatch repair and meiotic recombination |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ADD66 |
YKL206C |
Protein involved in 20S proteasome assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MGT1 |
YDL200C |
DNA repair methyltransferase (6-O-methylguanine-DNA methylase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTK3 |
YML112W |
Gamma subunit of C-terminal domain kinase I |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IME2 |
YJL106W |
Serine/threonine protein kinase involved in activation of meiosis |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ECM19 |
YLR390W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO2 |
YDR123C |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSH5 |
YDL154W |
Protein of the MutS family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IES4 |
YOR189W |
Component of the INO80 chromatiin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HOP1 |
YIL072W |
Meiosis-specific protein required for chromosome synapsis |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HOP2 |
YGL033W |
Meiosis-specific protein that localizes to chromosomes |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CQD1 |
YPL109C |
UbiB family mitochondrial protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ATP18 |
YML081C-A |
Subunit of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADE16 |
YLR028C |
Enzyme of 'de novo' purine biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UFD1 |
YGR048W |
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| UBP7 |
YIL156W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| REC8 |
YPR007C |
Meiosis-specific component of the sister chromatid cohesion complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TOR1 |
YJR066W |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Synthetic Haploinsufficiency |
| SNM1 |
YDR478W |
Ribonuclease MRP complex subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SHG1 |
YBR258C |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEI1 |
YLR404W |
Seipin involved in lipid droplet (LD) assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPL6B |
YLR448W |
Ribosomal 60S subunit protein L6B |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PMS1 |
YNL082W |
ATP-binding protein required for mismatch repair |
genetic |
1 |
1 |
1 |
Positive Genetic |
| WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP6 |
YDR449C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAD1 |
YFR005C |
Conserved zinc-finger domain protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE1 |
YLR007W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTC3 |
YBL056W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTC4 |
YBR125C |
Cytoplasmic type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TNA1 |
YGR260W |
High affinity nicotinic acid plasma membrane permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHC3 |
YJL059W |
Protein required for the ATP-dependent transport of arginine |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL14A |
YKL006W |
Ribosomal 60S subunit protein L14A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OAR1 |
YKL055C |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL22A |
YLR061W |
Ribosomal 60S subunit protein L22A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XDJ1 |
YLR090W |
Chaperone with a role in facilitating mitochondrial protein import |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEX13 |
YLR191W |
Peroxisomal importomer complex component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCM1 |
YNL022C |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NMA111 |
YNL123W |
Serine protease and general molecular chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THI6 |
YPL214C |
Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL43A |
YPR043W |
Ribosomal 60S subunit protein L43A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VBA5 |
YKR105C |
Plasma membrane protein of the Major Facilitator Superfamily (MFS) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| OCA6 |
YDR067C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HOB2 |
YPR117W |
Protein with structural similarity to lipid transport protein Vps13p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| AIM11 |
YER093C-A |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CTH1 |
YDR151C |
mRNA binding protein, member of the CCCH zinc finger family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ICS2 |
YBR157C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HED1 |
YDR014W-A |
Meiosis-specific protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CCW12 |
YLR110C |
Cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DGK1 |
YOR311C |
Diacylglycerol kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
