| MCM22 |
YJR135C |
Outer kinetochore protein and component of the Ctf3 subcomplex |
physical |
11 |
3 |
9 |
Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
9 |
3 |
8 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
8 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
8 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
6 |
2 |
6 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
| MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
6 |
3 |
5 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
physical |
6 |
2 |
5 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
physical |
5 |
2 |
5 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
5 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
5 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CBF2 |
YGR140W |
Essential kinetochore protein |
genetic |
5 |
3 |
3 |
Dosage Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| CNN1 |
YFR046C |
Kinetochore protein |
physical |
5 |
3 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-Western |
| DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Co-crystal Structure, Affinity Capture-MS, Affinity Capture-MS |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
4 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect |
| MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
physical |
3 |
2 |
3 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
| NKP2 |
YLR315W |
Central kinetochore protein and subunit of the Ctf19 complex |
physical |
3 |
2 |
3 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-MS |
| CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect |
| IML3 |
YBR107C |
Outer kinetochore protein and component of the Ctf19 complex |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| NKP1 |
YDR383C |
Central kinetochore protein and subunit of the Ctf19 complex |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| HHT1 |
YBR010W |
Histone H3 |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality |
| AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
physical |
3 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| NSL1 |
YPL233W |
Essential component of the MIND kinetochore complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SMC3 |
YJL074C |
Subunit of the multiprotein cohesin complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| IST3 |
YIR005W |
Component of the U2 snRNP |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| NPL3 |
YDR432W |
RNA-binding protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
| SCM3 |
YDL139C |
Nonhistone component of centromeric chromatin |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| IPL1 |
YPL209C |
Aurora kinase of chromosomal passenger complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
2 |
1 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence |
| FAR7 |
YFR008W |
Protein involved in recovery from pheromone-induced cell cycle arrest |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| AFT1 |
YGL071W |
Transcription factor involved in iron utilization and homeostasis |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PRP22 |
YER013W |
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PEX18 |
YHR160C |
Peroxin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| SWI6 |
YLR182W |
Transcription cofactor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| JNM1 |
YMR294W |
Component of the yeast dynactin complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| EPL1 |
YFL024C |
Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CEF1 |
YMR213W |
Essential splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLF1 |
YLR117C |
Member of the NineTeen Complex (NTC) |
physical |
1 |
1 |
1 |
Two-hybrid |
| CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HAP5 |
YOR358W |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM3 |
YLR438C-A |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ACC1 |
YNR016C |
Acetyl-CoA carboxylase, biotin containing enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HHF1 |
YBR009C |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| END3 |
YNL084C |
EH domain-containing protein involved in endocytosis |
physical |
1 |
1 |
1 |
Two-hybrid |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HDA2 |
YDR295C |
Subunit of HDA1 histone deacetylase complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
Two-hybrid |
| DOT6 |
YER088C |
Protein involved in rRNA and ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BNA3 |
YJL060W |
Kynurenine aminotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG11 |
YPR049C |
Adapter protein for pexophagy and the Cvt targeting pathway |
physical |
1 |
1 |
1 |
Two-hybrid |
| IPA1 |
YJR141W |
Protein implicated in pre-mRNA processing and proteasomal degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTF13 |
YMR094W |
Subunit of the CBF3 complex |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| ADD66 |
YKL206C |
Protein involved in 20S proteasome assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIN5 |
YOR028C |
Basic leucine zipper (bZIP) transcription factor of the yAP-1 family |
physical |
1 |
1 |
1 |
Two-hybrid |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NKP2 |
YLR315W |
Central kinetochore protein and subunit of the Ctf19 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PRP18 |
YGR006W |
Splicing factor and component of snRNP U5 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPC11 |
YDR045C |
RNA polymerase III subunit C11 |
physical |
1 |
1 |
1 |
Two-hybrid |
| SWI5 |
YDR146C |
Transcription factor that recruits Mediator and Swi/Snf complexes |
physical |
1 |
1 |
1 |
Two-hybrid |
| PPT1 |
YGR123C |
Protein serine/threonine phosphatase |
physical |
1 |
1 |
1 |
Two-hybrid |
| THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
physical |
1 |
1 |
1 |
Two-hybrid |
| THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
physical |
1 |
1 |
1 |
Two-hybrid |
| YAP7 |
YOL028C |
Transcriptional repressor of nitric oxide oxidase |
physical |
1 |
1 |
1 |
Two-hybrid |
| NFI1 |
YOR156C |
SUMO E3 ligase |
physical |
1 |
1 |
1 |
Two-hybrid |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| SPC25 |
YER018C |
Component of the kinetochore-associated Ndc80 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| YBP2 |
YGL060W |
Central kinetochore associated protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RDS1 |
YCR106W |
Putative zinc cluster transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
| PSH1 |
YOL054W |
E3 ubiquitin ligase targeting centromere-binding protein Cse4p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SLF1 |
YDR515W |
RNA binding protein that associates with polysomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
physical |
1 |
1 |
1 |
Two-hybrid |
| YGR130C |
YGR130C |
Component of the eisosome with unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
physical |
1 |
1 |
1 |
Two-hybrid |
| VAB2 |
YEL005C |
Subunit of the BLOC-1 complex involved in endosomal maturation |
physical |
1 |
1 |
1 |
Two-hybrid |
| REC107 |
YJR021C |
Protein involved in early stages of meiotic recombination |
physical |
1 |
1 |
1 |
Two-hybrid |
| SMY1 |
YKL079W |
Kinesin-like myosin passenger-protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| NYV1 |
YLR093C |
v-SNARE component of the vacuolar SNARE complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| MEI5 |
YPL121C |
Meiosis-specific protein involved in meiotic recombination |
physical |
1 |
1 |
1 |
Two-hybrid |
| NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NSL1 |
YPL233W |
Essential component of the MIND kinetochore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| WIP1 |
YDR374W-A |
Kinetochore localized protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MHF2 |
YDL160C-A |
Component of the heterotetrameric MHF histone-fold complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
physical |
1 |
1 |
1 |
PCA |
| ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| STO1 |
YMR125W |
Large subunit of the nuclear mRNA cap-binding protein complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MIF2 |
YKL089W |
Centromeric CDEIII region binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIP1 |
YOR330C |
Mitochondrial DNA polymerase gamma |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STP4 |
YDL048C |
Protein containing a Kruppel-type zinc-finger domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SYC1 |
YOR179C |
Subunit of the APT subcomplex of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUF1 |
YOR187W |
Mitochondrial translation elongation factor Tu (EF-Tu) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RML2 |
YEL050C |
Mitochondrial ribosomal protein of the large subunit (L2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUB1 |
YML085C |
Alpha-tubulin |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRPL8 |
YJL063C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PRP45 |
YAL032C |
Protein required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLU7 |
YDR088C |
RNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC19 |
YDR201W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QNS1 |
YHR074W |
Glutamine-dependent NAD(+) synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP40 |
YKL012W |
U1 snRNP protein involved in splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMD2 |
YLR275W |
Core Sm protein Sm D2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP1 |
YNL221C |
Subunit of RNase MRP, nuclear RNase P and telomerase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIM23 |
YNR017W |
Essential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| WRS1 |
YOL097C |
Cytoplasmic tryptophanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTR10 |
YOR160W |
Nuclear import receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAD3 |
YLR316C |
Subunit of tRNA-specific adenosine-34 deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRG9 |
YNL213C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YOR072W-B |
YOR072W-B |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NRG2 |
YBR066C |
Transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDR248C |
YDR248C |
Putative gluconokinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PET122 |
YER153C |
Mitochondrial translational activator specific for the COX3 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YIP5 |
YGL161C |
Protein that interacts with Rab GTPases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QCR9 |
YGR183C |
Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEM1 |
YHR004C |
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XPT1 |
YJR133W |
Xanthine-guanine phosphoribosyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UFD4 |
YKL010C |
Ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKL075C |
YKL075C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEH1 |
YKR007W |
Subunit of the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP190 |
YKR028W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLR031W |
YLR031W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHM2 |
YLR058C |
Cytosolic serine hydroxymethyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UCC1 |
YLR224W |
F-box protein and component of SCF ubiquitin ligase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS38 |
YLR360W |
Part of a Vps34p phosphatidylinositol 3-kinase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSC1 |
YML128C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWS2 |
YNL081C |
Putative mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG1 |
YOL067C |
Transcription factor (bHLH) involved in interorganelle communication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGT2 |
YOR007C |
Glutamine-rich cytoplasmic cochaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPH1 |
YOR270C |
Subunit a of the vacuolar-ATPase V0 domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIM20 |
YOR275C |
Protein involved in proteolytic activation of Rim101p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MNE1 |
YOR350C |
Protein involved in splicing Group I aI5-beta intron from COX1 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAR1 |
YPL239W |
Nucleocytoplasmic shuttling assembly chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIB2 |
YGL023C |
Phosphatidylinositol 3-phosphate binding protein |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GCN4 |
YEL009C |
bZIP transcriptional activator of amino acid biosynthetic genes |
physical |
1 |
1 |
1 |
Two-hybrid |
| CAK1 |
YFL029C |
Cyclin-dependent kinase-activating kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LAA2 |
YBL010C |
Clathrin adaptor (adaptin) accessory protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSE4 |
YKL049C |
Centromeric histone H3-like protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECO1 |
YFR027W |
Acetyltransferase required for sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
physical |
1 |
1 |
1 |
Two-hybrid |
| BIK1 |
YCL029C |
Microtubule-associated protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSF1 |
YLR087C |
Protein with structural similarity to lipid transport protein Vps13p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DAD4 |
YDR320C-A |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
Two-hybrid |
| COQ10 |
YOL008W |
Coenzyme Q (ubiquinone) binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARG56 |
YER069W |
Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| KIN4 |
YOR233W |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIL1 |
YOR304C-A |
Protein that binds Bud6p and has a role in actin cable assembly |
physical |
1 |
1 |
1 |
Two-hybrid |
| CYT1 |
YOR065W |
Cytochrome c1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERR1 |
YOR393W |
Putative phosphopyruvate hydratase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DFG10 |
YIL049W |
Probable polyprenol reductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| EFM5 |
YGR001C |
S-adenosylmethionine-dependent lysine methyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ECM4 |
YKR076W |
S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LNP1 |
YHR192W |
Lunapark family member involved in ER network formation |
physical |
1 |
1 |
1 |
Two-hybrid |
| LAS21 |
YJL062W |
Mannose-ethanolamine phosphotransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCH2 |
YKL221W |
Protein with similarity to mammalian monocarboxylate permeases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HMI1 |
YOL095C |
Mitochondrial inner membrane localized ATP-dependent DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DAN1 |
YJR150C |
Cell wall mannoprotein |
genetic |
1 |
1 |
1 |
Negative Genetic |
