Standard name Systematic name Name description Description
APN1 YKL114C Major apurinic/apyrimidinic endonuclease Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity
Visualize the interactome of APN1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.242 NaN NaN
Nucleus 0.803 0.827 0.843
Vac/Vac Memb NaN 0.153 0.072
Cytoplasm NaN NaN 0.085

GFP localization & abundance

GFP localization GFP abundance
mitochondrion, nucleus 7250

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
APN1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 17 4 16 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 12 5 10 Phenotypic Enhancement, Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 12 4 10 Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 11 4 9 Phenotypic Enhancement, Synthetic Lethality, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 7 2 7 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 7 3 6 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 6 3 6 Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 6 3 4 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
UNG1 YML021C Uracil-DNA glycosylase genetic 5 2 5 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
RAD52 YML032C Protein involved in homologous recombination genetic 5 4 4 Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
RAD18 YCR066W E3 ubiquitin ligase genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 3 3 3 Negative Genetic, Phenotypic Enhancement, Synthetic Rescue
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
TPP1 YMR156C DNA 3'-phosphatase genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 3 2 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
SML1 YML058W Ribonucleotide reductase inhibitor genetic 3 2 2 Synthetic Lethality, Synthetic Rescue, Synthetic Rescue
RAD2 YGR258C Single-stranded DNA endonuclease genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
DUT1 YBR252W Deoxyuridine triphosphate diphosphatase (dUTPase) genetic 2 2 2 Synthetic Growth Defect, Dosage Rescue
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SAW1 YAL027W 5'- and 3'-flap DNA binding protein genetic 2 2 2 Negative Genetic, Synthetic Lethality
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
RAD17 YOR368W Checkpoint protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
RAD24 YER173W Checkpoint protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
MSH1 YHR120W DNA-binding protein of the mitochondria genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 2 Negative Genetic, Negative Genetic
KTR6 YPL053C Probable mannosylphosphate transferase genetic 2 1 2 Negative Genetic, Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RAD53 YPL153C DNA damage response kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
PIR1 YKL164C O-glycosylated protein required for cell wall stability physical 2 2 1 Affinity Capture-Western, Two-hybrid
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
APE3 YBR286W Vacuolar aminopeptidase Y genetic 1 1 1 Negative Genetic
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein physical 1 1 1 Affinity Capture-MS
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 Affinity Capture-MS
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Biochemical Activity
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
SPS1 YDR523C STE20-family GCKIII protein kinase physical 1 1 1 Reconstituted Complex
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Proximity Label-MS
MRPL15 YLR312W-A Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Proximity Label-MS
MRPL28 YDR462W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Proximity Label-MS
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions physical 1 1 1 Affinity Capture-MS
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Rescue
HIM1 YDR317W Protein of unknown function involved in DNA repair genetic 1 1 1 Phenotypic Enhancement
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Dosage Lethality
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Positive Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Positive Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Synthetic Rescue
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Phenotypic Suppression
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
YIR016W YIR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Synthetic Growth Defect
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Synthetic Growth Defect
HNT3 YOR258W DNA 5' AMP hydrolase involved in DNA repair genetic 1 1 1 Synthetic Growth Defect
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Phenotypic Suppression
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Phenotypic Enhancement
RAD51 YER095W Strand exchange protein genetic 1 1 1 Phenotypic Enhancement
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Synthetic Growth Defect
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Synthetic Growth Defect
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 1 1 1 Phenotypic Enhancement
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Synthetic Rescue
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Synthetic Lethality
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Synthetic Rescue
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Synthetic Lethality
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Synthetic Lethality
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Synthetic Lethality
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Synthetic Lethality
PDS1 YDR113C Securin genetic 1 1 1 Synthetic Rescue
FCY1 YPR062W Cytosine deaminase genetic 1 1 1 Positive Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
VFA1 YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting genetic 1 1 1 Negative Genetic
BUD9 YGR041W Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
PCT1 YGR202C Cholinephosphate cytidylyltransferase genetic 1 1 1 Negative Genetic
DAL1 YIR027C Allantoinase genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 1 1 1 Synthetic Lethality
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
ISN1 YOR155C Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase genetic 1 1 1 Negative Genetic
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
ECM23 YPL021W Non-essential protein of unconfirmed function genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic